Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 9 (2012)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 9 (2012)

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Research Article

Article
Related articles
Page: 1
Published online: 17 Aug 2012
CitationforRelated articles | Full Text | PDF (124.4 KB)
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Editorial

Editorial
Combining aspirin and proton pump inhibitors: for whom the warning bell tolls?
Morten Würtz (Research Fellow) MD & Erik Lerkevang Grove MD PhD
Pages: 1051-1055
Published online: 27 Jul 2012
AbstractforCombining aspirin and proton pump inhibitors: for whom the warning bell tolls? | Full Text | References | PDF (201.7 KB)
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Free Access

Reviews

Review Article
Mathematical modeling of tumor growth and tumor growth inhibition in oncology drug development
Apexa Bernard, Holly Kimko, Dinesh Mital & Italo Poggesi
Pages: 1057-1069
Published online: 26 May 2012
AbstractforMathematical modeling of tumor growth and tumor growth inhibition in oncology drug development | Full Text | References | PDF (433 KB)
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Review Article
Investigative safety science as a competitive advantage for Pharma
Jonathan Moggs (Head of Molecular Toxicology) (Global Head of Preclinical Safety) (Global Head of Discovery and Investigative Safety) DPhil, Pierre Moulin (Head of Discovery and Investigative Pathology) PhD MD, Francois Pognan (Head of Biochemical and Translational Toxicology) PhD, Dominique Brees (Head of Immunology and Safety Biomarkers) PhD DVM ACVP, Michele Leonard (Portfolio Management and Scientific Coordination) PhD, Steve Busch (Head of In Vivo and Endocrine Models) PhD, Andre Cordier (Consultant for Discovery and Investigative Safety) PhD MD, David J Heard (Head of Preclinical Safety Informatics) PhD, Michael Kammüller (Head of Immunology) PhD, Michael Merz PhD, Page Bouchard DVM DACVP & Salah-Dine Chibout DPhil
Pages: 1071-1082
Published online: 07 Jul 2012
AbstractforInvestigative safety science as a competitive advantage for Pharma | Full Text | References | PDF (267.9 KB)
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Review Article
An update on chemotherapy and tumor gene expression profiles in breast cancer
Sing-Huang Tan & Soo-Chin Lee
Pages: 1083-1113
Published online: 11 Jun 2012
AbstractforAn update on chemotherapy and tumor gene expression profiles in breast cancer | Full Text | References | PDF (357 KB)
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Review Article
Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates
James J Cali (Director of Research) PhD, Dongping Ma (Senior Scientist) MS, Monika G Wood (Senior Scientist) MS, Poncho L Meisenheimer (Director of Chemistry Research) PhD & Dieter H Klaubert (Director of Chemistry, Advanced Technologies) PhD
Pages: 1115-1130
Published online: 11 Jun 2012
AbstractforBioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates | Full Text | References | PDF (656.5 KB)
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Review Article
Probe ADME and Test Hypotheses: a PATH beyond clearance in vitro–in vivo correlations in early drug discovery
Leslie C Bell & Jianling Wang
Pages: 1131-1155
Published online: 11 Jun 2012
AbstractforProbe ADME and Test Hypotheses: a PATH beyond clearance in vitro–in vivo correlations in early drug discovery | Full Text | References | PDF (938.3 KB)
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Review Article
Role of reactive metabolites in the circulation in extrahepatic toxicity
Roy M Irving & Adnan A Elfarra
Pages: 1157-1172
Published online: 11 Jun 2012
AbstractforRole of reactive metabolites in the circulation in extrahepatic toxicity | Full Text | References | PDF (357.5 KB)
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Review Article
Sex-related differences in renal toxicodynamics in rodents
Andrea Trevisan, Federica Chiara, Michele Mongillo, Luigi Quintieri & Patrizia Cristofori
Pages: 1173-1188
Published online: 07 Jul 2012
AbstractforSex-related differences in renal toxicodynamics in rodents | Full Text | References | PDF (265.4 KB)
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Drug Evaluations

Article
Pharmacokinetic evaluation of armodafinil for the treatment of bipolar depression
Peter Niemegeers MD, Kristof E Maudens PhD, Manuel Morrens MD PhD, Lisbeth Patteet, Leen Joos, Hugo Neels PhD & Bernard GC Sabbe MD PhD
Pages: 1189-1197
Published online: 18 Jul 2012
AbstractforPharmacokinetic evaluation of armodafinil for the treatment of bipolar depression | Full Text | References | PDF (227.1 KB)
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Article
Pharmacokinetic and clinical evaluation of esomeprazole and ASA for the prevention of gastroduodenal ulcers in cardiovascular patients
Marc Bardou, Alan N Barkun, Samia Hamza, Isabelle Le Ray & Françoise Goirand
Pages: 1199-1208
Published online: 31 Jul 2012
AbstractforPharmacokinetic and clinical evaluation of esomeprazole and ASA for the prevention of gastroduodenal ulcers in cardiovascular patients | Full Text | References | PDF (255.8 KB)
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Article
Evaluation of the pharmacokinetics, preclinical, and clinical efficacy of lenalidomide for the treatment of multiple myeloma
Sara Bringhen (Medical Doctor) , Francesca Gay (Medical Doctor) , Chiara Pautasso (Pharmacist) , Chiara Cerrato (Medical Doctor) , Mario Boccadoro (Professor, Medical Doctor) & Antonio Palumbo (Medical Doctor)
Pages: 1209-1222
Published online: 03 Aug 2012
AbstractforEvaluation of the pharmacokinetics, preclinical, and clinical efficacy of lenalidomide for the treatment of multiple myeloma | Full Text | References | PDF (250.9 KB)
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