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Volume 1, Issue 1

Expert Opinion on Therapeutic Targets

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Expert Opinion on Therapeutic Targets, Volume 1, Issue 1 (1997)

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Emerging Therapeutic Targets, Volume 1, Issue 1 (1997)

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Vol 28, 2024 Vol 27, 2023 Vol 26, 2022 Vol 25, 2021 Vol 24, 2020 Vol 23, 2019 Vol 22, 2018 Vol 21, 2017 Vol 20, 2016 Vol 19, 2015 Vol 18, 2014 Vol 17, 2013 Vol 16, 2012 Vol 15, 2011 Vol 14, 2010 Vol 13, 2009 Vol 12, 2008 Vol 11, 2007 Vol 10, 2006 Vol 9, 2005 Vol 8, 2004 Vol 7, 2003 Vol 6, 2002 Vol 5, 2001 Vol 5, 2001 Vol 4, 2000 Vol 3, 1999 Vol 2, 1998 Volume 1, 1997

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Article

Inhibition of PDE4 (Type 4) Cyclic AMP-specific Phosphodiesterase Isoforms

Miles D Houslay

Pages: 1-4

Published online: 02 Mar 2011

First Page PreviewforInhibition of PDE4 (Type 4) Cyclic AMP-specific Phosphodiesterase Isoforms | References | PDF (235.9 KB)

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Article

Inhibition of CD4-MHC Class II Interaction

Ziwei Huang & Song Li

Pages: 5-8

Published online: 02 Mar 2011

First Page PreviewforInhibition of CD4-MHC Class II Interaction | References | PDF (213.2 KB)

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Article

Modulation of Monocyte Activation

Herbert Schwarz

Pages: 9-11

Published online: 02 Mar 2011

First Page PreviewforModulation of Monocyte Activation | References | PDF (157.7 KB)

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Article

Binding of Helicobacter Pylori (HP) to the Human Stomach Mucosa

C Basset, J Holton, T Rademacher, I Roitt & P Youinou

Pages: 13-15

Published online: 02 Mar 2011

First Page PreviewforBinding of Helicobacter Pylori (HP) to the Human Stomach Mucosa | References | PDF (144.4 KB)

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Article

Urease and Cytotoxin of Helicobacter Pylori (HP) - Immune Response

J Holton, C-Y Yiu & D Vaira

Pages: 17-19

Published online: 02 Mar 2011

First Page PreviewforUrease and Cytotoxin of Helicobacter Pylori (HP) - Immune Response | References | PDF (147.1 KB)

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Article

Adhesins of Helicobacter pylori (HP)

J Holton, C-Y Yiu & D Vaira

Pages: 21-23

Published online: 02 Mar 2011

First Page PreviewforAdhesins of Helicobacter pylori (HP) | References | PDF (133 KB)

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Article

Interleukin (IL)-1β Receptor Type II (Gene Therapy), IL-1β Gene, Nitric Oxide Synthase (NOS), Cyclo-Oxygenase (COX)-2, Tumour Necrosis Factor (TNF)-α Convertase, IL-17, Superoxide Dismutase (SOD), Differential Display of Novel Genes Expressed in Human Osteoarthritis-Affected Cartilage, Human Arthritis-Affected Cartilage Proteases

Ashok R Amin

Pages: 25-28

Published online: 02 Mar 2011

First Page PreviewforInterleukin (IL)-1β Receptor Type II (Gene Therapy), IL-1β Gene, Nitric Oxide Synthase (NOS), Cyclo-Oxygenase (COX)-2, Tumour Necrosis Factor (TNF)-α Convertase, IL-17, Superoxide Dismutase (SOD), Differential Display of Novel Genes Expressed in Human Osteoarthritis-Affected Cartilage, Human Arthritis-Affected Cartilage Proteases | References | PDF (237.1 KB)

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Article

Inhibition and/or Inactivation of Nitric Oxide Synthase Isoforms

Donald J Wolff

Pages: 29-32

Published online: 02 Mar 2011

First Page PreviewforInhibition and/or Inactivation of Nitric Oxide Synthase Isoforms | References | PDF (199 KB)

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Article

Genes Expressed in Cell Types after Their Exposure to UV Stresses or Oxidative Stresses, e.g., Keratinocytes, Fibroblasts in the Skin, or Endothelial Cells, Neurones or Astrocytes in Age-Related Pathologies Where Oxidative Stresses have been Shown to Occur, such as Atherosclerosis, Parkinson's Disease, Alzheimer's Disease

O Toussaint, ES Gonos, C Franceschi, BFC Clark, SLS Rattan & J Remade

Pages: 33-37

Published online: 02 Mar 2011

First Page PreviewforGenes Expressed in Cell Types after Their Exposure to UV Stresses or Oxidative Stresses, e.g., Keratinocytes, Fibroblasts in the Skin, or Endothelial Cells, Neurones or Astrocytes in Age-Related Pathologies Where Oxidative Stresses have been Shown to Occur, such as Atherosclerosis, Parkinson's Disease, Alzheimer's Disease | References | PDF (318.2 KB)

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Article

Cysteine Proteases of Malaria Parasites, Including a Haemoglobinase of Plasmodium Falciparum (Falcipain)

Philip J Rosenthal

Pages: 39-42

Published online: 02 Mar 2011

First Page PreviewforCysteine Proteases of Malaria Parasites, Including a Haemoglobinase of Plasmodium Falciparum (Falcipain) | References | PDF (188.3 KB)

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Article

Reversal and Inhibition of ADP-Ribosylation (A-R) of GTP-Binding Proteins Catalysed by Bacterial Toxins

Gertrude Falk & Richard Shiells

Pages: 43-46

Published online: 02 Mar 2011

First Page PreviewforReversal and Inhibition of ADP-Ribosylation (A-R) of GTP-Binding Proteins Catalysed by Bacterial Toxins | References | PDF (169 KB)

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Article

DNA Sequence of Staphylococcus Aureus

Wafa A El-Adhami, Peter R Stewart & Klaus I Matthaei

Pages: 47-50

Published online: 02 Mar 2011

First Page PreviewforDNA Sequence of Staphylococcus Aureus | References | PDF (227.4 KB)

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Article

Prevention of Damage (Cytoprotection) to Respiratory Epithelium Caused by Bacterial Infection

Robert Wilson & Ruth Dowling

Pages: 51-54

Published online: 02 Mar 2011

First Page PreviewforPrevention of Damage (Cytoprotection) to Respiratory Epithelium Caused by Bacterial Infection | References | PDF (202.4 KB)

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Article

HIV Reverse Transcriptase (RT) and HIV Protease Inhibitors

JC Chermann, JL Kraus & M Camplo

Pages: 55-57

Published online: 02 Mar 2011

First Page PreviewforHIV Reverse Transcriptase (RT) and HIV Protease Inhibitors | References | PDF (141 KB)

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Article

Virus-Infected Organs, Particularly Monocyte/Macrophages, Helper T-Lymphocytes and Lymphoid Germinal Centres

Reto A Schwendener & Herbert Schott

Pages: 59-63

Published online: 02 Mar 2011

First Page PreviewforVirus-Infected Organs, Particularly Monocyte/Macrophages, Helper T-Lymphocytes and Lymphoid Germinal Centres | References | PDF (228.7 KB)

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Article

Immunisation with a Novel Hepatitis B Vaccine

Ivan M Roitt & Yasmin Thanavala

Pages: 65-67

Published online: 02 Mar 2011

First Page PreviewforImmunisation with a Novel Hepatitis B Vaccine | PDF (96.1 KB)

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Article

De Novo Biosynthesis of Purines

Stefano Manfredini & Paolo La Colla

Pages: 69-72

Published online: 02 Mar 2011

First Page PreviewforDe Novo Biosynthesis of Purines | References | PDF (198.1 KB)

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Article

Inhibition of the Formation of the Alzheimer's β-Amyloid Peptide

NM Hooper & AJ Turner

Pages: 73-77

Published online: 02 Mar 2011

First Page PreviewforInhibition of the Formation of the Alzheimer's β-Amyloid Peptide | References | PDF (155.2 KB)

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Article

Inhibition of Alzheimer's Beta (Aβ) Amyloid Fibril Formation

M Pappolla, P Bozner, C Soto, M Zagorski, H Shao, B Frangione & J Ghiso

Pages: 77-80

Published online: 02 Mar 2011

First Page PreviewforInhibition of Alzheimer's Beta (Aβ) Amyloid Fibril Formation | References | PDF (172.9 KB)

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Article

The WW Domain and its Proline-Rich Ligand in Alzheimer's Disease and Muscular Dystrophy

Marius Sudol

Pages: 81-84

Published online: 02 Mar 2011

First Page PreviewforThe WW Domain and its Proline-Rich Ligand in Alzheimer's Disease and Muscular Dystrophy | References | PDF (250.9 KB)

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Article

Stimulation of Brain Nicotinic Acetylcholine Receptors (nAChR) and Inhibition of Brain Acetylcholinesterase (AChE) Activity

Jerry J Buccafusco & James C Powers

Pages: 85-88

Published online: 02 Mar 2011

First Page PreviewforStimulation of Brain Nicotinic Acetylcholine Receptors (nAChR) and Inhibition of Brain Acetylcholinesterase (AChE) Activity | References | PDF (204.8 KB)

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Article

Acetylcholine Esterase and All Elements of the Cholinergic and Monoaminergic Transmitter Signalling Pathways

E Perry, AT Pickering, J Court, RM Wilkins, D Mantle, AG Young, E Lazenby, EF Marshall & EF Marshall

Pages: 89-92

Published online: 02 Mar 2011

First Page PreviewforAcetylcholine Esterase and All Elements of the Cholinergic and Monoaminergic Transmitter Signalling Pathways | References | PDF (183.3 KB)

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Article

Centrally-Acting Antagonist of Muscarinic M4 Receptors

John D Salamone

Pages: 93-95

Published online: 02 Mar 2011

First Page PreviewforCentrally-Acting Antagonist of Muscarinic M4 Receptors | References | PDF (194.3 KB)

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Article

Prevention of Glutamate-Evoked Cytotoxicity

C Volonté

Pages: 97-100

Published online: 02 Mar 2011

First Page PreviewforPrevention of Glutamate-Evoked Cytotoxicity | References | PDF (185.6 KB)

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Article

Agonists and Antagonists at Neuropeptide (i.e., Somatostatin and Neuropeptide Y) Receptors in the CNS [1,2]

Annamaria Vezzani

Pages: 101-103

Published online: 02 Mar 2011

First Page PreviewforAgonists and Antagonists at Neuropeptide (i.e., Somatostatin and Neuropeptide Y) Receptors in the CNS [1,2] | References | PDF (145.5 KB)

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Article

Angiotensin II Synthesis and Receptor

Paul R Gard

Pages: 105-107

Published online: 02 Mar 2011

First Page PreviewforAngiotensin II Synthesis and Receptor | References | PDF (166.4 KB)

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Article

Activation of Spinal kappa₂ Opioid Receptors

Robert M Caudle, Andrew J Mannes & Michael J Iadarola

Pages: 109-112

Published online: 02 Mar 2011

First Page PreviewforActivation of Spinal kappa₂ Opioid Receptors | References | PDF (222.2 KB)

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Article

Inhibition of a Thrombin-Glycoprotein Ib(GPIb)-GPIIb/IIIa Pathway

Gerald Soslau, Doris A Morgan & Isadore Brodsky

Pages: 113-116

Published online: 02 Mar 2011

First Page PreviewforInhibition of a Thrombin-Glycoprotein Ib(GPIb)-GPIIb/IIIa Pathway | References | PDF (183.3 KB)

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Article

Up or Down Regulation of HB2, a Candidate High Density Lipoprotein Receptor

Noel Fidge, Alana Mitchell, Akiyo Matsumoto & Kazuo Kondo

Pages: 117-119

Published online: 02 Mar 2011

First Page PreviewforUp or Down Regulation of HB2, a Candidate High Density Lipoprotein Receptor | References | PDF (149 KB)

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Article

Endothelin (ET), its Precursor BigET, and its Receptor, ET_A

BA Wallace

Pages: 121-123

Published online: 02 Mar 2011

First Page PreviewforEndothelin (ET), its Precursor BigET, and its Receptor, ET_A | References | PDF (128.7 KB)

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Article

Inhibition of Membrane-Bound Aminopeptidase P

William H Simmons

Pages: 125-128

Published online: 02 Mar 2011

First Page PreviewforInhibition of Membrane-Bound Aminopeptidase P | References | PDF (229 KB)

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Article

Inhibition of Phosphatidylinositol-Specific Phospholipase C (PLC)

Elizabeth A Woodcock, Xiao-Jun Du & Anthony M Dart

Pages: 129-132

Published online: 02 Mar 2011

First Page PreviewforInhibition of Phosphatidylinositol-Specific Phospholipase C (PLC) | References | PDF (190.3 KB)

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Article

I_to Blockade by 4-Aminopyridine: A New Approach to Stabilise the Electrical Activity of the Heart

I Gussak

Pages: 133-135

Published online: 02 Mar 2011

First Page PreviewforI_to Blockade by 4-Aminopyridine: A New Approach to Stabilise the Electrical Activity of the Heart | References | PDF (154 KB)

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Article

Inactivation of Adrenal Serotonin₄ (5-HT₄) Receptors

H Lefebvre & JM Kuhn

Pages: 137-140

Published online: 02 Mar 2011

First Page PreviewforInactivation of Adrenal Serotonin₄ (5-HT₄) Receptors | References | PDF (194.6 KB)

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Article

Inhibition of Type 3 3α-Hydroxysteroid Dehydrogenase (3α-HSD)

TM Penning, HK Lin, JM Jez & JW Ricigliano

Pages: 141-145

Published online: 02 Mar 2011

First Page PreviewforInhibition of Type 3 3α-Hydroxysteroid Dehydrogenase (3α-HSD) | References | PDF (314 KB)

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Article

Bioactivation of Chemotherapeutic Agents

Johannes Everse

Pages: 147-149

Published online: 02 Mar 2011

First Page PreviewforBioactivation of Chemotherapeutic Agents | References | PDF (151.3 KB)

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Article

Prevention of Chemoresistance in Human Tumours

Rudolf Fahrig

Pages: 151-153

Published online: 02 Mar 2011

First Page PreviewforPrevention of Chemoresistance in Human Tumours | References | PDF (155.3 KB)

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Article

Activation of the Immune System

Heather J Muenchen & Surinder K Aggarwal

Pages: 155-157

Published online: 02 Mar 2011

First Page PreviewforActivation of the Immune System | References | PDF (152.2 KB)

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Article

Inhibition of Pyrimidine Biosynthesis Pathways, Inhibition of DNA Synthesis, Modification of the Cell Cycle, Induction of Apoptosis

Reto A Schwendener & Herbert Schott

Pages: 159-163

Published online: 02 Mar 2011

First Page PreviewforInhibition of Pyrimidine Biosynthesis Pathways, Inhibition of DNA Synthesis, Modification of the Cell Cycle, Induction of Apoptosis | References | PDF (267 KB)

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Article

Inhibition of the Autocrine Loop Regulated by the Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor-α (TGF-α) Ligand

Marvin Rubenstein & Patrick D Guinna

Pages: 165-168

Published online: 02 Mar 2011

First Page PreviewforInhibition of the Autocrine Loop Regulated by the Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor-α (TGF-α) Ligand | References | PDF (222.6 KB)

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Article

Receptor Protein Expressed on Leukaemia Cells

Reiner Class & Michael Zeppezauer

Pages: 169-170

Published online: 02 Mar 2011

First Page PreviewforReceptor Protein Expressed on Leukaemia Cells | References | PDF (213.4 KB)

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Article

Fibroblast Growth Factor Receptor (FGFR)

Hing Y Leung & David E Neal

Pages: 173-175

Published online: 02 Mar 2011

First Page PreviewforFibroblast Growth Factor Receptor (FGFR) | References | PDF (110.1 KB)

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Article

Heptahelical, G-Protein Linked Receptors (Cholecystokinin [CCK-A], Gastrin [CCK-B], Vasoactive Intestinal Polypeptide [VIP], Calcitonin Gene Related Polypeptide [CGRP], Pituitary Adenylate Cyclase Activating Polypeptide [PACAP])

Joseph R Pisegna & Stephen A Wank

Pages: 177-181

Published online: 02 Mar 2011

First Page PreviewforHeptahelical, G-Protein Linked Receptors (Cholecystokinin [CCK-A], Gastrin [CCK-B], Vasoactive Intestinal Polypeptide [VIP], Calcitonin Gene Related Polypeptide [CGRP], Pituitary Adenylate Cyclase Activating Polypeptide [PACAP]) | References | PDF (282.5 KB)

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Article

The Insulin-Like Growth Factor 1 Receptor (IGF-IR)

Renato Baserga

Pages: 183-185

Published online: 02 Mar 2011

First Page PreviewforThe Insulin-Like Growth Factor 1 Receptor (IGF-IR) | PDF (127.9 KB)

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Article

Sialomucin Complex (SMC)

Kermit L Carraway

Pages: 187-189

Published online: 02 Mar 2011

First Page PreviewforSialomucin Complex (SMC) | References | PDF (170.9 KB)

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Article

Substrates and/or Inhibitors of IMP-GMP Specific Cytosolic 5′-Nucleotidase (cN-II)

Maria Grazia Tozzi, Francesco Sgarrella, Simone Allegrini, Marcella Camici & Rossana Pesi

Pages: 191-194

Published online: 02 Mar 2011

First Page PreviewforSubstrates and/or Inhibitors of IMP-GMP Specific Cytosolic 5′-Nucleotidase (cN-II) | References | PDF (205.1 KB)

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Article

Inhibition of Poly(ADP-Ribose)Polymerase (PARP)

Michael D Threadgill

Pages: 195-198

Published online: 02 Mar 2011

First Page PreviewforInhibition of Poly(ADP-Ribose)Polymerase (PARP) | References | PDF (210.1 KB)

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Article

Epidermal Growth Factor Receptor

EJJ van Zoelen

Pages: 199-202

Published online: 02 Mar 2011

First Page PreviewforEpidermal Growth Factor Receptor | References | PDF (216.2 KB)

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Article

Inhibition of Glyoxalase I (EC4.4.1.5)

Paul J Thornalley

Pages: 203-206

Published online: 02 Mar 2011

First Page PreviewforInhibition of Glyoxalase I (EC4.4.1.5) | References | PDF (176.8 KB)

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Article

Bone Genes

Nigel A Morrison, G Nicholson, R Mason & R Quinn

Pages: 207-213

Published online: 02 Mar 2011

First Page PreviewforBone Genes | References | PDF (435.9 KB)

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Article

Spermatozoa

Carlo Forestaw, Marco Rossato & Francesco Di Virgilio

Pages: 215-217

Published online: 02 Mar 2011

First Page PreviewforSpermatozoa | References | PDF (160.4 KB)

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Article

Fertility Control - Alternative Strategy

Ivan M Roitt, Peter Delves & Torben Lund

Pages: 219-221

Published online: 02 Mar 2011

First Page PreviewforFertility Control - Alternative Strategy | PDF (120.6 KB)

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Article

Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1

Brian R Walker, Jonathan R Seckl & Christopher RW Edwards

Pages: 223-227

Published online: 02 Mar 2011

First Page PreviewforInhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 | References | PDF (262.7 KB)

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Article

Improved Insulin Action

CJ Bailey

Pages: 229-233

Published online: 02 Mar 2011

First Page PreviewforImproved Insulin Action | References | PDF (111.7 KB)

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Article

Insulin Delivery

CJ Bailey

Pages: 233-235

Published online: 02 Mar 2011

First Page PreviewforInsulin Delivery | References | PDF (117.7 KB)

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Article

Prostanoid FP² Receptor

James M Ntambi

Pages: 237-240

Published online: 02 Mar 2011

First Page PreviewforProstanoid FP² Receptor | References | PDF (180.4 KB)

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Article

Prevention of Free Radical Oxidative Damage

Stefano Manfredini, Silvia Vertuani, Gabriella Calviello & Paola Palozza

Pages: 241-244

Published online: 02 Mar 2011

First Page PreviewforPrevention of Free Radical Oxidative Damage | References | PDF (218.6 KB)

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Article

7-Hydroxylated Metabolites of Circulating 3β-Hydroxysteroids are Native Anti-Glucocorticoids

Robert Morfin

Pages: 245-248

Published online: 02 Mar 2011

First Page Previewfor7-Hydroxylated Metabolites of Circulating 3β-Hydroxysteroids are Native Anti-Glucocorticoids | References | PDF (209.3 KB)

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Article

Selective Inhibition of Mutant Mitochondrial DNA Replication

Robert W Taylor, Patrick F Chinnery, Kim M Clark, Robert N Lightowlers & Douglass M Turnbull

Pages: 249-252

Published online: 02 Mar 2011

First Page PreviewforSelective Inhibition of Mutant Mitochondrial DNA Replication | References | PDF (240.2 KB)

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Article

Long-Term Regulation of Specific Serum Metabolite Levels

Johannes Everse

Pages: 253-255

Published online: 02 Mar 2011

First Page PreviewforLong-Term Regulation of Specific Serum Metabolite Levels | References | PDF (138.2 KB)

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Article

Catheter with Antibacterial and Antifungal Properties

Illner H, Barber Ae, Griswold Ja & Hsia Wg

Pages: 257-260

Published online: 02 Mar 2011

First Page PreviewforCatheter with Antibacterial and Antifungal Properties | References | PDF (269.7 KB)

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Article

A Simple Near-Patient Urine Test for Nicotine and Its Metabolites to Assess Smoking Habit

Graham F Cope, Pamela Nayyar, John Gibbons & Roger Bunce

Pages: 263-266

Published online: 02 Mar 2011

First Page PreviewforA Simple Near-Patient Urine Test for Nicotine and Its Metabolites to Assess Smoking Habit | References | PDF (228.2 KB)

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Article

Epidermis

James A Gallagher & Wayne B Bowler

Pages: 267-269

Published online: 02 Mar 2011

First Page PreviewforEpidermis | References | PDF (122.1 KB)

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Article

Pharmaceutical Desensitisation Or Fade

Richard G Lanzara

Pages: 271-273

Published online: 02 Mar 2011

First Page PreviewforPharmaceutical Desensitisation Or Fade | References | PDF (142.2 KB)

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Article

Drug Interaction with Specific Biological Membranes

H-J Freisleben, E Antonopoulos & G Zimmer

Pages: 275-277

Published online: 02 Mar 2011

First Page PreviewforDrug Interaction with Specific Biological Membranes | References | PDF (139.5 KB)

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Index

Pages: 279-281

Published online: 02 Mar 2011

First Page PreviewforIndex | PDF (87.5 KB)

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Foreword

Article

Foreword

James Drake Publisher & Andrew Ward Senior Editor

Page: iii

Published online: 02 Mar 2011

CitationforForeword | PDF (39.6 KB)

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Introduction

Page: v

Published online: 02 Mar 2011

CitationforIntroduction | PDF (73.3 KB)

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