Leukemia & Lymphoma, Volume 59, Issue 6 (2018)

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Leukemia & Lymphoma, Volume 59, Issue 6 (2018)

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Commentaries

Success is built on failures: tackling the challenge of ponatinib failure
Devendra Hiwase & David Ross
Pages: 1279-1281
Published online: 31 Jan 2018
First Page PreviewforSuccess is built on failures: tackling the challenge of ponatinib failure | Full Text | References | PDF (411.1 KB) | Supplemental
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Transforming growth factor superfamily ligands and links to tumorigenesis
Imo Akpan, Barbara Pro & Leonidas C. Platanias
Pages: 1282-1283
Published online: 01 May 2018
CitationforTransforming growth factor superfamily ligands and links to tumorigenesis | Full Text | References | PDF (240.7 KB) | Supplemental
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Review

Acute myeloid leukemia and the infectious diseases consultant
Victor Mulanovich & Dimitrios P. Kontoyiannis
Pages: 1284-1291
Published online: 15 Sep 2017
AbstractforAcute myeloid leukemia and the infectious diseases consultant | Full Text | References | PDF (650.8 KB) | Supplemental
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Rational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies
Steven Grant
Pages: 1292-1299
Published online: 24 Aug 2017
AbstractforRational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies | Full Text | References | PDF (657.7 KB)
  • 569 Views
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Managing multiple myeloma in elderly patients
Evan Diamond, Oscar B. Lahoud & Heather Landau
Pages: 1300-1311
Published online: 28 Aug 2017
AbstractforManaging multiple myeloma in elderly patients | Full Text | References | PDF (909.9 KB) | Supplemental
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Original Article: Clinical

Life after ponatinib failure: outcomes of chronic and accelerated phase CML patients who discontinued ponatinib in the salvage setting
Prajwal Boddu, Abdul Rashid Shah, Gautam Borthakur, Srdan Verstovsek, Guillermo Garcia-Manero, Naval Daver, Tapan Kadia, Farhad Ravandi, Nitin Jain, Ahmad Alhuraiji, Jan Burger, Steven Kornblau, Sherry Pierce, Sara Dellasala, Elias Jabbour, Hagop Kantarjian & Jorge Cortes
Pages: 1312-1322
Published online: 03 Oct 2017
AbstractforLife after ponatinib failure: outcomes of chronic and accelerated phase CML patients who discontinued ponatinib in the salvage setting | Full Text | References | PDF (1.7 MB) | Supplemental
  • 490 Views
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Determinants of 1-year survival in critically ill acute leukemia patients: a GRRR-OH study
Márcio Tavares, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Etienne Lengliné, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon & Elie Azoulay
Pages: 1323-1331
Published online: 13 Sep 2017
AbstractforDeterminants of 1-year survival in critically ill acute leukemia patients: a GRRR-OH study | Full Text | References | PDF (878.1 KB) | Supplemental
  • 262 Views
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Cytogenetic risk stratification may predict allogeneic hematopoietic stem cell transplantation outcomes for chronic myelomonocytic leukemia
Kenji Motohashi, Shin Fujisawa, Noriko Doki, Takeshi Kobayashi, Takehiko Mori, Kensuke Usuki, Masatsugu Tanaka, Shinichiro Fujiwara, Shinichi Kako, Yasuyuki Aoyama, Masahiro Onoda, Shingo Yano, Moritaka Gotoh, Heiwa Kanamori, Satoshi Takahashi, Shinichiro Okamoto & for the Kanto Study Group for Cell Therapy (KSGCT)
Pages: 1332-1337
Published online: 16 Oct 2017
AbstractforCytogenetic risk stratification may predict allogeneic hematopoietic stem cell transplantation outcomes for chronic myelomonocytic leukemia | Full Text | References | PDF (744.2 KB) | Supplemental
  • 250 Views
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Risk adjusted therapy in chronic lymphocytic leukemia: a phase II cancer trials Ireland (CTRIAL-IE [ICORG 07-01]) study of fludarabine, cyclophosphamide, and rituximab therapy evaluating response adapted, abbreviated frontline therapy with FCR in non-del(17p) CLL
Niamh Appleby, David O’Brien, Fiona M. Quinn, Liam Smyth, Johanna Kelly, Imelda Parker, Kathleen Scott, Mary R. Cahill, Gerard Crotty, Helen Enright, Brian Hennessy, Andrew Hodgson, Maeve Leahy, Hilary O’Leary, Michael O’Dwyer, Amjad Hayat & Elisabeth A. Vandenberghe
Pages: 1338-1347
Published online: 19 Sep 2017
AbstractforRisk adjusted therapy in chronic lymphocytic leukemia: a phase II cancer trials Ireland (CTRIAL-IE [ICORG 07-01]) study of fludarabine, cyclophosphamide, and rituximab therapy evaluating response adapted, abbreviated frontline therapy with FCR in non-del(17p) CLL | Full Text | References | PDF (1.1 MB) | Supplemental
  • 528 Views
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The impact of Agent Orange exposure on prognosis and management in patients with chronic lymphocytic leukemia: a National Veteran Affairs Tumor Registry Study
Craig Mescher, David Gilbertson, Nicole M. Randall, Gobind Tarchand, Julie Tomaska, Lisa Baumann Kreuziger & Vicki A. Morrison
Pages: 1348-1355
Published online: 14 Sep 2017
AbstractforThe impact of Agent Orange exposure on prognosis and management in patients with chronic lymphocytic leukemia: a National Veteran Affairs Tumor Registry Study | Full Text | References | PDF (919.7 KB) | Supplemental
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Improved survival outcomes with the addition of rituximab to initial therapy for chronic lymphocytic leukemia: a comparative effectiveness analysis in the province of British Columbia, Canada
Lauren J. Lee, Cynthia L. Toze, Steven J. T. Huang, Tanya L. Gillan, Joseph M. Connors, Laurie H. Sehn, Helene Bruyere, Heather Leitch, Khaled M. Ramadan & Alina S. Gerrie
Pages: 1356-1363
Published online: 16 Oct 2017
AbstractforImproved survival outcomes with the addition of rituximab to initial therapy for chronic lymphocytic leukemia: a comparative effectiveness analysis in the province of British Columbia, Canada | Full Text | References | PDF (1 MB) | Supplemental
  • 264 Views
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Carfilzomib–dexamethasone versus subcutaneous or intravenous bortezomib in relapsed or refractory multiple myeloma: secondary analysis of the phase 3 ENDEAVOR study
Hartmut Goldschmidt, Philippe Moreau, Heinz Ludwig, Ruben Niesvizky, Wee-Joo Chng, Douglas Joshua, Katja Weisel, Andrew Spencer, Robert Z. Orlowski, Shibao Feng, Karim S. Iskander & Meletios A. Dimopoulos
Pages: 1364-1374
Published online: 22 Sep 2017
AbstractforCarfilzomib–dexamethasone versus subcutaneous or intravenous bortezomib in relapsed or refractory multiple myeloma: secondary analysis of the phase 3 ENDEAVOR study | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1112 Views
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Survival of patients with CD20-negative variants of large B-cell lymphoma: an analysis of the National Cancer Data Base
Lindor Qunaj, Jorge J. Castillo & Adam J. Olszewski
Pages: 1375-1383
Published online: 11 Oct 2017
AbstractforSurvival of patients with CD20-negative variants of large B-cell lymphoma: an analysis of the National Cancer Data Base | Full Text | References | PDF (1.4 MB) | Supplemental
  • 590 Views
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Clinical outcome of patients with early stage favorable Hodgkin lymphoma treated with ABVD × two cycles followed by FDG-PET/CT restaging and 20 Gy of involved-site radiotherapy
Sophia C. Kamran, Heather A. Jacene, Yu-Hui Chen, Peter M. Mauch & Andrea K. Ng
Pages: 1384-1390
Published online: 22 Sep 2017
AbstractforClinical outcome of patients with early stage favorable Hodgkin lymphoma treated with ABVD × two cycles followed by FDG-PET/CT restaging and 20 Gy of involved-site radiotherapy | Full Text | References | PDF (1.4 MB) | Supplemental
  • 243 Views
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MYC immunohistochemical and cytogenetic analysis are required for identification of clinically relevant aggressive B cell lymphoma subtypes
Philipp W. Raess, Stephen R. Moore, Michael J. Cascio, Jennifer Dunlap, Guang Fan, Ken Gatter, Susan B. Olson & Rita M. Braziel
Pages: 1391-1398
Published online: 03 Sep 2017
AbstractforMYC immunohistochemical and cytogenetic analysis are required for identification of clinically relevant aggressive B cell lymphoma subtypes | Full Text | References | PDF (1.2 MB) | Supplemental
  • 460 Views
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Autoimmune manifestations associated with lymphoma: characteristics and outcome in a multicenter retrospective cohort study
Vincent Jachiet, Arsène Mekinian, Fabrice Carrat, Eric Grignano, Aurelia Retbi, Jean-Jacques Boffa, Pierre Ronco, Eric Rondeau, Jérémie Sellam, Francis Berenbaum, Olivier Chazouillères, Jean Capron, Sonia Alamowitch, Francois Chasset, Camille Frances, Paul Coppo, Olivier Fain & on behalf of French Network of systemic and immune disorders associated with hemopathies and cancer (MINHEMON)
Pages: 1399-1405
Published online: 03 Oct 2017
AbstractforAutoimmune manifestations associated with lymphoma: characteristics and outcome in a multicenter retrospective cohort study | Full Text | References | PDF (911.8 KB) | Supplemental
  • 488 Views
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Comparison of chemoradiotherapy with radiotherapy alone for early-stage extranodal natural killer/T-cell lymphoma, nasal type in elderly patients
Chang Su, Kevin A. Nguyen, Harrison X. Bai, Dhikshitha Balaji, Ya Cao, Giorgos Karakousis, Paul J. Zhang, Guiying Zhang & Rong Xiao
Pages: 1406-1412
Published online: 05 Oct 2017
AbstractforComparison of chemoradiotherapy with radiotherapy alone for early-stage extranodal natural killer/T-cell lymphoma, nasal type in elderly patients | Full Text | References | PDF (907.9 KB) | Supplemental
  • 221 Views
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Real-world effectiveness of brentuximab vedotin versus physicians’ choice chemotherapy in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplantation in the United Kingdom and Germany
Erin A. Zagadailov, Shelby Corman, Viktor Chirikov, Courtney Johnson, Cynthia Macahilig, Brian Seal, Mehul R. Dalal, Paul J. Bröckelmann & Tim Illidge
Pages: 1413-1419
Published online: 18 Oct 2017
AbstractforReal-world effectiveness of brentuximab vedotin versus physicians’ choice chemotherapy in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplantation in the United Kingdom and Germany | Full Text | References | PDF (829.3 KB) | Supplemental
  • 2961 Views
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Open Access
Radiotherapy plus rituximab as first-line regimen for localized follicular lymphoma
Emanuele Cencini, Benedetta Puccini, Luigi Rigacci, Alberto Fabbri, Sofia Kovalchuk, Lara Mannelli, Gemma Benelli, Tommaso Carfagno, Gabriele Simontacchi, Monica Bocchia & Alberto Bosi
Pages: 1420-1426
Published online: 10 Oct 2017
AbstractforRadiotherapy plus rituximab as first-line regimen for localized follicular lymphoma | Full Text | References | PDF (573.7 KB) | Supplemental
  • 454 Views
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Original Article: Research

Proteomics profiling identifies induction of caveolin-1 in chronic lymphocytic leukemia cells by bone marrow stromal cells
Hima V. Vangapandu, Huiqin Chen, William G. Wierda, Michael J. Keating, Anil Korkut & Varsha Gandhi
Pages: 1427-1438
Published online: 03 Oct 2017
AbstractforProteomics profiling identifies induction of caveolin-1 in chronic lymphocytic leukemia cells by bone marrow stromal cells | Full Text | References | PDF (1.8 MB) | Supplemental
  • 302 Views
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The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells
Noriyoshi Iriyama, Hirotsugu Hino, Shota Moriya, Masaki Hiramoto, Yoshihiro Hatta, Masami Takei & Keisuke Miyazawa
Pages: 1439-1450
Published online: 18 Sep 2017
AbstractforThe cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells | Full Text | References | PDF (2 MB) | Supplemental
  • 719 Views
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Clinical significance of chemokine receptor CXCR4 and mammalian target of rapamycin (mTOR) expression in patients with diffuse large B-cell lymphoma
Zi-Zhen Xu, Jian-Kang Shen, Shu-Qing Zhao & Jun-Min Li
Pages: 1451-1460
Published online: 27 Sep 2017
AbstractforClinical significance of chemokine receptor CXCR4 and mammalian target of rapamycin (mTOR) expression in patients with diffuse large B-cell lymphoma | Full Text | References | PDF (1.8 MB) | Supplemental
  • 361 Views
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Letter to the Editor

Role and regulation of microRNAs targeting BTK in acute myelogenous leukemia
Lara Rizzotto, Tzung-Huei Lai, Arianna Bottoni, Jennifer A. Woyach, Rosa Lapalombella, Clara D. Bloomfield, John C. Byrd & Deepa Sampath
Pages: 1461-1465
Published online: 18 Sep 2017
First Page PreviewforRole and regulation of microRNAs targeting BTK in acute myelogenous leukemia | Full Text | References | PDF (1.5 MB) | Supplemental
  • 214 Views
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Phase I dose escalation study of the anti-CD2 monoclonal antibody, siplizumab, with DA-EPOCH-R in aggressive peripheral T-cell lymphomas
Joseph Roswarski, Mark Roschewski, Andrea Lucas, Christopher Melani, Stefania Pittaluga, Elaine S. Jaffe, Seth M. Steinberg, Thomas A. Waldmann & Wyndham H. Wilson
Pages: 1466-1469
Published online: 16 Oct 2017
First Page PreviewforPhase I dose escalation study of the anti-CD2 monoclonal antibody, siplizumab, with DA-EPOCH-R in aggressive peripheral T-cell lymphomas | Full Text | References | PDF (518.1 KB) | Supplemental
  • 433 Views
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FDG-PET/CT findings of chronic active Epstein–Barr virus infection
Akira Toriihara, Ayako Arai, Masashi Nakadate, Kouhei Yamamoto, Ken-Ichi Imadome, Osamu Miura & Ukihide Tateishi
Pages: 1470-1473
Published online: 12 Oct 2017
First Page PreviewforFDG-PET/CT findings of chronic active Epstein–Barr virus infection | Full Text | References | PDF (818 KB) | Supplemental
  • 233 Views
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Incidence of second solid cancers in mastocytosis patients: a SEER database analysis
Velizar Shivarov, Ralitza Gueorguieva, Milena Ivanova & Angel Stoimenov
Pages: 1474-1477
Published online: 27 Sep 2017
First Page PreviewforIncidence of second solid cancers in mastocytosis patients: a SEER database analysis | Full Text | References | PDF (725.5 KB) | Supplemental
  • 153 Views
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Phase-I randomized trial of doxorubicin hydrochloride liposome injection versus Caelyx® in multiple myeloma
Shravanti Bhowmik, Subhas Bhowmick, Kuntal Maiti, Amaresh Chakra, Pradeep Shahi & Thennati Rajamannar
Pages: 1478-1481
Published online: 10 Oct 2017
First Page PreviewforPhase-I randomized trial of doxorubicin hydrochloride liposome injection versus Caelyx® in multiple myeloma | Full Text | References | PDF (642.3 KB) | Supplemental
  • 224 Views
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Chemotherapy-free, triple combination of obinutuzumab, venetoclax and idasanutlin: antitumor activity in xenograft models of non-Hodgkin lymphoma
Frank Herting, Thomas Friess, Pablo Umaña, Steven Middleton & Christian Klein
Pages: 1482-1485
Published online: 15 Sep 2017
First Page PreviewforChemotherapy-free, triple combination of obinutuzumab, venetoclax and idasanutlin: antitumor activity in xenograft models of non-Hodgkin lymphoma | Full Text | References | PDF (526.3 KB)
  • 526 Views
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PET-CT in AML-related hemophagocytic lymphohistiocytosis
Prajwal Boddu, Sergio Pina Oviedo, Caitlin R. Rausch, Clinton Yam, Naval Daver, Hagop Kantarjian & Tapan M. Kadia
Pages: 1486-1489
Published online: 28 Sep 2017
First Page PreviewforPET-CT in AML-related hemophagocytic lymphohistiocytosis | Full Text | References | PDF (946.2 KB) | Supplemental
  • 162 Views
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Hidden FLT3-D835Y clone in FLT3-ITD-positive acute myeloid leukemia that evolved into very late relapse with T-lymphoblastic leukemia
Seiichiro Katagiri, Tomohiro Umezu, Kenko Azuma, Michiyo Asano, Daigo Akahane, Hideki Makishima, Kenichi Yoshida, Yosaku Watatani, Kenichi Chiba, Satoru Miyano, Seishi Ogawa, Junko H. Ohyashiki & Kazuma Ohyashiki
Pages: 1490-1493
Published online: 03 Oct 2017
First Page PreviewforHidden FLT3-D835Y clone in FLT3-ITD-positive acute myeloid leukemia that evolved into very late relapse with T-lymphoblastic leukemia | Full Text | References | PDF (647.8 KB) | Supplemental
  • 237 Views
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Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale
M. S. Zinter, A. Melton, A. J. Sabnis, C. C. Dvorak, B. M. Elicker, H. M. Nawaytou, R. J. Kameny & J. R. Fineman
Pages: 1494-1497
Published online: 28 Sep 2017
First Page PreviewforPulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale | Full Text | References | PDF (788.5 KB) | Supplemental
  • 306 Views
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Predictive performance of early warning scores in acute leukemia patients receiving induction chemotherapy
John L. Vaughn, David Kline, Nathan M. Denlinger, Leslie A. Andritsos, Matthew C. Exline & Alison R. Walker
Pages: 1498-1500
Published online: 13 Sep 2017
First Page PreviewforPredictive performance of early warning scores in acute leukemia patients receiving induction chemotherapy | Full Text | References | PDF (309.1 KB) | Supplemental
  • 158 Views
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Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells
Flávia Adolfo Corrocher, Luciana Bueno de Paiva, Adriana Silva Santos Duarte, Karla Priscila Ferro, Leonardo dos Reis Silveira, Tanes Iamamura de Lima, Sara Teresinha Olalla Saad & Mariana Lazarini
Pages: 1501-1504
Published online: 17 Oct 2017
First Page PreviewforReduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells | Full Text | References | PDF (1.7 MB) | Supplemental
  • 202 Views
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The advantages of switch to subcutaneous bortezomib in the real life
Silvia Mangiacavalli, Federica Cocito, Virginia Valeria Ferretti, Maya Ganzetti, Claudio Salvatore Cartia & Alessandro Corso
Pages: 1505-1507
Published online: 05 Oct 2017
First Page PreviewforThe advantages of switch to subcutaneous bortezomib in the real life | Full Text | References | PDF (300.4 KB) | Supplemental
  • 238 Views
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Pitfalls in short-tandem repeat analysis as quality control for sample mix-up of pediatric acute lymphoblastic leukemia patients
Patricia G. Hoogeveen, Maaike de Bie, Rianne Noordijk, Edwin Sonneveld, Anneke Koning-Goedheer, H. Berna Beverloo & Vincent H.J. van de der Velden
Pages: 1508-1510
Published online: 28 Sep 2017
First Page PreviewforPitfalls in short-tandem repeat analysis as quality control for sample mix-up of pediatric acute lymphoblastic leukemia patients | Full Text | References | PDF (592.1 KB) | Supplemental
  • 864 Views
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Open Access
A pediatric case of acute megakaryocytic leukemia with double chimeric transcripts of CBFA2T3-GLIS2 and DHH-RHEBL1
Kanako Mitsui-Sekinaka, Yujin Sekinaka, Yumi Ogura, Mamoru Honda, Ryo Ohyama, Chigusa Oyama, Kiyotaka Isobe, Makiko Mori, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Shigeaki Nonoyama & Hiroyuki Kawaguchi
Pages: 1511-1513
Published online: 18 Oct 2017
First Page PreviewforA pediatric case of acute megakaryocytic leukemia with double chimeric transcripts of CBFA2T3-GLIS2 and DHH-RHEBL1 | Full Text | References | PDF (455.5 KB) | Supplemental
  • 256 Views
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‘Real-world’ Australian experience of pomalidomide for relapsed and refractory myeloma
Ashleigh Scott, Nicholas Weber, Campbell Tiley, Kerry Taylor, John Taper, Simon Harrison, Kah-Lok Chan, Richard Stark, Cindy Lee, Kirk Morris, P. Joy Ho, Anthony Dodds, Sundra Ramanathan, Raj Ramakrishna, Anne-Marie Watson, Bradley Auguston, Fiona Kwok, Hang Quach, Pauline Warburton, Philip Rowlings & Peter Mollee
Pages: 1514-1516
Published online: 12 Oct 2017
First Page Previewfor‘Real-world’ Australian experience of pomalidomide for relapsed and refractory myeloma | Full Text | References | PDF (440.8 KB) | Supplemental
  • 600 Views
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