Leukemia & Lymphoma, Volume 60, Issue 7 (2019)

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Leukemia & Lymphoma, Volume 60, Issue 7 (2019)

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Commentary

Article Commentary
Ibrutinib dose and clinical outcome in chronic lymphocytic leukemia - learning from the ‘real world’
Prithviraj Bose, Lisa S. Chen & Varsha Gandhi
Pages: 1603-1605
Published online: 06 Feb 2019
First Page PreviewforIbrutinib dose and clinical outcome in chronic lymphocytic leukemia - learning from the ‘real world’ | Full Text | References | PDF (534 KB) | EPUB
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Article Commentary
Donor graft genotypes versus leukemia
Hannah K. Choe & Koen van Besien
Pages: 1606-1607
Published online: 26 Jun 2019
CitationforDonor graft genotypes versus leukemia | Full Text | References | PDF (238.8 KB) | EPUB
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Article Commentary
Antibody-based therapy in acute leukemia - beware the risks
Maximilian Stahl & Martin S. Tallman
Pages: 1608-1609
Published online: 17 Jun 2019
CitationforAntibody-based therapy in acute leukemia - beware the risks | Full Text | References | PDF (239.2 KB) | EPUB
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Review

Review
Treatment of aggressive B-cell non-Hodgkin lymphoma beyond frontline therapy in patients not eligible for stem cell transplantation: a structured review
Gilles A. Salles, Ruth Pettengell, Raul Cordoba, Monika Długosz-Danecka, Wojciech Jurczak & Hervé Tilly
Pages: 1610-1625
Published online: 31 Jan 2019
AbstractforTreatment of aggressive B-cell non-Hodgkin lymphoma beyond frontline therapy in patients not eligible for stem cell transplantation: a structured review | Full Text | References | PDF (1.4 MB) | EPUB
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Lymphoma Rounds from the Lymphoma Research Foundation. Editors: Koen Van Besien and Morton Coleman

Article
Combined use of tofacitinib (pan-JAK inhibitor) and ruxolitinib (a JAK1/2 inhibitor) for refractory T-cell prolymphocytic leukemia (T-PLL) with a JAK3 mutation
Alexandra Gomez-Arteaga, Elizabeth Margolskee, Mike T. Wei, Koen van Besien, Giorgio Inghirami & Steven Horwitz
Pages: 1626-1631
Published online: 18 Apr 2019
First Page PreviewforCombined use of tofacitinib (pan-JAK inhibitor) and ruxolitinib (a JAK1/2 inhibitor) for refractory T-cell prolymphocytic leukemia (T-PLL) with a JAK3 mutation | Full Text | References | PDF (1.9 MB) | EPUB
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Original Article: Research

Article
Dual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment
Yandong Shen, Kyle Crassini, Suneet Sandhu, Narjis Fatima, Richard I. Christopherson, Stephen P. Mulligan & O. Giles Best
Pages: 1632-1643
Published online: 16 Jan 2019
AbstractforDual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Original Article: Clinical

Article
The magnitude of improvement in progression-free survival with targeted therapy in relapsed/refractory chronic lymphocytic leukemia based on prognostic risk category: a systematic review and meta-analysis
Stefano Molica, Diana Giannarelli, Rosanna Mirabelli, Luciano Levato & Tait D. Shanafelt
Pages: 1644-1649
Published online: 05 Dec 2018
AbstractforThe magnitude of improvement in progression-free survival with targeted therapy in relapsed/refractory chronic lymphocytic leukemia based on prognostic risk category: a systematic review and meta-analysis | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 635 Views
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Article
Dose reductions in ibrutinib therapy are not associated with inferior outcomes in patients with chronic lymphocytic leukemia (CLL)
Othman S. Akhtar, Kristopher Attwood, Ian Lund, Ryan Hare, Francisco J. Hernandez-Ilizaliturri & Pallawi Torka
Pages: 1650-1655
Published online: 02 Jan 2019
AbstractforDose reductions in ibrutinib therapy are not associated with inferior outcomes in patients with chronic lymphocytic leukemia (CLL) | Full Text | References | PDF (762 KB) | EPUB
  • 860 Views
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Article
Rural and urban patients with diffuse large B-cell and follicular lymphoma experience reduced overall survival: a National Cancer DataBase study
Andrew J. Ritter, Jordan S. Goldstein, Amy A. Ayers & Christopher R. Flowers
Pages: 1656-1667
Published online: 11 Jan 2019
AbstractforRural and urban patients with diffuse large B-cell and follicular lymphoma experience reduced overall survival: a National Cancer DataBase study | Full Text | References | PDF (1 MB) | EPUB
  • 375 Views
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Original Article: Research

Article
Obinutuzumab plus chemotherapy followed by obinutuzumab monotherapy is cost-effective vs. rituximab plus chemotherapy followed by rituximab monotherapy for previously untreated follicular lymphoma patients in the United States
Gregory F. Guzauskas, Anthony Masaquel, Per-Olof Thuresson, Keith Dawson & David L. Veenstra
Pages: 1668-1676
Published online: 11 Jan 2019
AbstractforObinutuzumab plus chemotherapy followed by obinutuzumab monotherapy is cost-effective vs. rituximab plus chemotherapy followed by rituximab monotherapy for previously untreated follicular lymphoma patients in the United States | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 794 Views
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Original Article - Clinical

Article
Clinical presentation, treatment, and outcomes of patients with central nervous system involvement in extranodal natural killer/T-cell lymphoma
Kathryn S Nevel, Elena Pentsova & Mariza Daras
Pages: 1677-1684
Published online: 16 Jan 2019
AbstractforClinical presentation, treatment, and outcomes of patients with central nervous system involvement in extranodal natural killer/T-cell lymphoma | Full Text | References | PDF (921.6 KB) | EPUB
  • 310 Views
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Original Article: Research

Article
Skewing of the T-cell receptor repertoire in patients receiving rituximab after allogeneic hematopoietic cell transplantation: what lies beneath?
Apostolia Papalexandri, Maria Karypidou, Evangelia Stalika, Konstantina Kotta, Tasoula Touloumenidou, Panagiota Zerva, Angeliki Paleta, Despina Mallouri, Ioannis Batsis, Ioanna Sakellari, Ioannis Kotsianidis, Achilles Anagnostopoulos, Anastasia Hadzidimitriou, Dimitris Margaritis & Kostas Stamatopoulos
Pages: 1685-1692
Published online: 17 Jan 2019
AbstractforSkewing of the T-cell receptor repertoire in patients receiving rituximab after allogeneic hematopoietic cell transplantation: what lies beneath? | Full Text | References | PDF (758.9 KB) | EPUB
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Original Article: Clinical

Article
Prophylactic rituximab prevents EBV PTLD in haplo-cord transplant recipients at high risk
Koen Van Besien, Lizamarie Bachier-Rodriguez, Michael Satlin, Maxwell A. Brown, Usama Gergis, Danielle Guarneri, Jingmei Hsu, Adrienne A. Phillips, Sebastian A. Mayer, Amrita D. Singh, Rosemary Soave, Adriana Rossi, Catherine B. Small, Thomas J. Walsh, Hanna Rennert & Tsiporah B. Shore
Pages: 1693-1696
Published online: 10 Feb 2019
AbstractforProphylactic rituximab prevents EBV PTLD in haplo-cord transplant recipients at high risk | Full Text | References | PDF (409.2 KB) | EPUB
  • 698 Views
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Original Article

Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML
Rodica P. Bunaciu, Robert J. MacDonald, Holly A. Jensen, Feng Gao, Xin Wang, Lynn Johnson, Jeffrey D. Varner & Andrew Yen
Pages: 1697-1708
Published online: 20 Dec 2018
AbstractforRetinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML | Full Text | References | PDF (1.9 MB) | EPUB
  • 197 Views
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Original Article: Research

Article
MicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5
Xiaoxiao Jiang, Yanhong Cheng, Chaojie Hu, Aimei Zhang, Yingli Ren & Xiucai Xu
Pages: 1709-1720
Published online: 05 Dec 2018
AbstractforMicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5 | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 209 Views
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Original Article

Article
Chronic myelomonocytic leukemia treated with 5-azacytidine – results from the Hellenic 5-Azacytidine Registry: proposal of a new risk stratification system
Panagiotis T. Diamantopoulos, Ioannis Kotsianidis, Argiris Symeonidis, Vassiliki Pappa, Athanasios Galanopoulos, Dimitrios Gogos, Stamatios Karakatsanis, Helen Papadaki, Aikaterini Palla, Eleftheria Hatzimichael, Maria Dimou, Sotirios Papageorgiou, Sosana Delimpasis, Maria Papaioannou, Menelaos Papoutselis, Alexandra Kourakli, Dimitrios Tsokanas, Achilles Anagnostopoulos, Christos K. Kontos, Panayiotis Panayiotidis, Nora-Athina Viniou & On behalf of the Hellenic MDS study group
Pages: 1721-1730
Published online: 14 Nov 2018
AbstractforChronic myelomonocytic leukemia treated with 5-azacytidine – results from the Hellenic 5-Azacytidine Registry: proposal of a new risk stratification system | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 257 Views
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Original Article: Clinical

Article
Decitabine for myelodysplastic syndromes: dose comparison in a real world clinical setting
Yanling Ren, Huifang Jiang, Fangjing Shi, Li Ye, Yingwan Luo, Xinping Zhou, Chen Mei, Liya Ma, Weilai Xu, Peipei Lin, Chao Hu, Jie Jin & Hongyan Tong
Pages: 1731-1739
Published online: 08 Jan 2019
AbstractforDecitabine for myelodysplastic syndromes: dose comparison in a real world clinical setting | Full Text | References | PDF (1.3 MB) | EPUB
  • 161 Views
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Original Article : Clinical

Article
Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4
Reuven J. Schore, Meenakshi Devidas, Archie Bleyer, Gregory H. Reaman, Naomi Winick, Mignon L. Loh, Elizabeth A. Raetz, William L. Carroll, Stephen P. Hunger & Anne L. Angiolillo
Pages: 1740-1748
Published online: 10 Jan 2019
AbstractforPlasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4 | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 927 Views
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Original Article

Article
A strategy of Day14 bone marrows and early intervention is not superior to a strategy of noDay14 bone marrows and delayed intervention in patients with acute myeloid leukemia
Mohammad Refaei, Osman Radhwi, Irwindeep Sandhu, Joseph Brandwein, Hao Wei (Linda) Sun & Lalit Saini
Pages: 1749-1757
Published online: 02 May 2019
AbstractforA strategy of Day14 bone marrows and early intervention is not superior to a strategy of noDay14 bone marrows and delayed intervention in patients with acute myeloid leukemia | Full Text | References | PDF (966.3 KB) | EPUB
  • 92 Views
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Original Article: Clinical

Article
Second allogeneic hematopoietic cell transplantation for relapse after first allografts
Boglarka Gyurkocza, Rainer Storb, Thomas R. Chauncey, David G. Maloney, Barry E. Storer & Brenda M. Sandmaier
Pages: 1758-1766
Published online: 22 Jan 2019
AbstractforSecond allogeneic hematopoietic cell transplantation for relapse after first allografts | Full Text | References | PDF (1.7 MB) | EPUB
  • 307 Views
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Article
A phase 2 study of pracinostat combined with ruxolitinib in patients with myelofibrosis
Prithviraj Bose, Mahesh Swaminathan, Naveen Pemmaraju, Alessandra Ferrajoli, Elias J. Jabbour, Naval G. Daver, Courtney D. DiNardo, Yesid Alvarado, Musa Yilmaz, Julie Huynh-Lu, Wei Qiao, Xuemei Wang, Aurelio Matamoros, Lingsha Zhou, Sherry Pierce, Kurt D. Schroeder, Hagop M. Kantarjian & Srdan Verstovsek
Pages: 1767-1774
Published online: 11 Jan 2019
AbstractforA phase 2 study of pracinostat combined with ruxolitinib in patients with myelofibrosis | Full Text | References | PDF (905.8 KB) | EPUB | Supplemental
  • 349 Views
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Original Article: Research

Article
Discovery of donor genotype associated with long-term survival of patients with hematopoietic stem cell transplantation in refractory acute myeloid leukemia
Chan-Young Ock, Heewon Seo, Dae-Yoon Kim, Byung Joo Min, Yoomi Park, Hyun Sub Cheong, Hyung-Lae Kim, Eun-Young Song, Inho Kim, Sung-Soo Yoon, Ju Han Kim & Youngil Koh
Pages: 1775-1781
Published online: 03 Dec 2018
AbstractforDiscovery of donor genotype associated with long-term survival of patients with hematopoietic stem cell transplantation in refractory acute myeloid leukemia | Full Text | References | PDF (898.4 KB) | EPUB | Supplemental
  • 286 Views
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Original Article: Clinical

Article
Gastrointestinal Behcet’s-like disease with myelodysplastic neoplasms with trisomy 8: a French case series and literature review
Nadege Wesner, Louis Drevon, Alexis Guedon, Jean Baptiste Fraison, Benjamin Terrier, Salim Trad, Jean Emmanuel Kahn, Achille Aouba, Jerome Gillard, Matthieu Ponsoye, Thomas Hanslik, Clement Gourguechon, Eric Liozon, Kamel Laribi, Julien Rossignol, Olivier Hermine, Philippe Seksik, Lionel Adès, Fabrice Carrat, Pierre Fenaux, Arsène Mekinian, Olivier Fain & On behalf GFM and MINHEMON (French Network of dysimmune disorders associated with hemopathies)
Pages: 1782-1788
Published online: 20 Nov 2018
AbstractforGastrointestinal Behcet’s-like disease with myelodysplastic neoplasms with trisomy 8: a French case series and literature review | Full Text | References | PDF (733.5 KB) | EPUB
  • 764 Views
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Original Article: Research

Article
Item nonresponse on the Myeloproliferative Neoplasms Symptom Assessment Form (MPN-SAF): a comparison of missing data strategies
Gina L. Mazza, Katie L. Kunze, Blake T. Langlais, Heidi E. Kosiorek, Todd A. DeWees, Holly L. Geyer, Robyn M. Scherber, Ruben A. Mesa & Amylou C. Dueck
Pages: 1789-1795
Published online: 17 Jan 2019
AbstractforItem nonresponse on the Myeloproliferative Neoplasms Symptom Assessment Form (MPN-SAF): a comparison of missing data strategies | Full Text | References | PDF (665.9 KB) | EPUB
  • 214 Views
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Original Article: Clinical

Article
The effect of tyrosine kinase inhibitor interruption and interferon use on pregnancy outcomes and long-term disease control in chronic myeloid leukemia
Masa Lasica, Abbey Willcox, Kate Burbury, David M. Ross, Susan Branford, Jason Butler, Robin Filshie, Henry Januszewicz, David Joske, Anthony Mills, David Simpson, Constantine Tam, Kerry Taylor, Anne-Marie Watson, Max Wolf & Andrew Grigg
Pages: 1796-1802
Published online: 11 Jan 2019
AbstractforThe effect of tyrosine kinase inhibitor interruption and interferon use on pregnancy outcomes and long-term disease control in chronic myeloid leukemia | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 764 Views
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Original Article – Research

Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study
Daniele Campa, Alessandro Martino, Angelica Macauda, Marek Dudziński, Anna Suska, Agnieszka Druzd-Sitek, Marc-Steffen Raab, Victor Moreno, Stefanie Huhn, Aleksandra Butrym, Juan Sainz, Gergely Szombath, Marcin Rymko, Herlander Marques, Fabienne Lesueur, Annette Juul Vangsted, Ulla Vogel, Marcin Kruszewski, Edyta Subocz, Gabriele Buda, Elżbieta Iskierka-Jażdżewska, Rafael Ríos, Maximilian Merz, Ben Schöttker, Grzegorz Mazur, Emeline Perrial, Joaquin Martinez-Lopez, Katja Butterbach, Ramón García Sanz, Hartmut Goldschmidt, Hermann Brenner, Krzysztof Jamroziak, Rui Manuel Reis, Katalin Kadar, Charles Dumontet, Marzena Wątek, Eva Kannik Haastrup, Grzegorz Helbig, Artur Jurczyszyn, Andrés Jerez, Judit Varkonyi, Torben Barington, Norbert Grzasko, Jan Maciej Zaucha, Vibeke Andersen, Daria Zawirska & Federico Canzian
Pages: 1803-1811
Published online: 11 Jan 2019
AbstractforGenetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 496 Views
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Original Article: Clinical

Article
Is complement C1q a potential marker for tumor burden and immunodeficiency in multiple myeloma?
Ronghui Yang, Jin Huang, Huanxin Ma, Shiwen Li, Xin Gao, Yingshu Liu, Jing Shen & Aijun Liao
Pages: 1812-1818
Published online: 10 Jan 2019
AbstractforIs complement C1q a potential marker for tumor burden and immunodeficiency in multiple myeloma? | Full Text | References | PDF (931.7 KB) | EPUB | Supplemental
  • 253 Views
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Letter to the Editor

Letter
Re-mobilization of hematopoietic progenitors for further autografting after prior myelo-ablative high-dose chemotherapy and autologous hematopoietic stem cell transplantation; the role of plerixafor
Christos Kosmas, Eleftheria Kranidioti, Aikaterini Kosma, Maria Karakosta, Constantinos Miltiadous, Anastasios Grivas, Aggelos Athanasopoulos & Evangelos Lianos
Pages: 1819-1822
Published online: 08 Jan 2019
First Page PreviewforRe-mobilization of hematopoietic progenitors for further autografting after prior myelo-ablative high-dose chemotherapy and autologous hematopoietic stem cell transplantation; the role of plerixafor | Full Text | References | PDF (509.7 KB) | EPUB
  • 152 Views
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Letter
PALB2 variant status in hematological malignancies – a potential therapeutic target?
Ceri E. Oldreive, Philip J. Byrd, Grant S. Stewart, Alexander J. Taylor, Sana Farhat, Anna Skowronska, Edward Smith, Manoj Raghavan, Dragana Janic, Lidija Dokmanovic, Sam Clokie, Nicholas Davies, Marwan Kwok, Guy Pratt, Shankara Paneesha, Paul Moss, Tatjana Stankovic & Malcolm Taylor
Pages: 1823-1826
Published online: 07 Jan 2019
First Page PreviewforPALB2 variant status in hematological malignancies – a potential therapeutic target? | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 277 Views
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Letter
Increased risk of adverse acute myeloid leukemia after anti-CD19-targeted immunotherapies in KMT2A-rearranged acute lymphoblastic leukemia: a case report and review of the literature
Elise Fournier, Luca Inchiappa, Carole Delattre, Jean-Michel Pignon, Frédérique Danicourt, Maxime Bemba, Catherine Roche-Lestienne, Agnès Daudignon, Gauthier Decool, Christophe Roumier, Florent Dumezy, Loïc Fournier, Nathalie Grardel, Claude Preudhomme & Nicolas Duployez
Pages: 1827-1830
Published online: 07 Jan 2019
First Page PreviewforIncreased risk of adverse acute myeloid leukemia after anti-CD19-targeted immunotherapies in KMT2A-rearranged acute lymphoblastic leukemia: a case report and review of the literature | Full Text | References | PDF (873.5 KB) | EPUB | Supplemental
  • 350 Views
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Letter
RARγ-rearrangements resemble acute promyelocytic leukemia and benefit from 3 + 7 regimen
Xiang Zhang, Fenglin Li, Jinghan Wang, Shanshan Suo, Qing Ling, Wenjuan Yu & Jie Jin
Pages: 1831-1834
Published online: 11 Jan 2019
First Page PreviewforRARγ-rearrangements resemble acute promyelocytic leukemia and benefit from 3 + 7 regimen | Full Text | References | PDF (763.3 KB) | EPUB
  • 185 Views
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Letter
Guillain Barré syndrome heralding the diagnosis of angioimmunoblastic T-cell lymphoma
Priyadarshini Pathak, Stuthi Perimbeti, Ashley Ames & Alison J. Moskowitz
Pages: 1835-1838
Published online: 16 Jan 2019
First Page PreviewforGuillain Barré syndrome heralding the diagnosis of angioimmunoblastic T-cell lymphoma | Full Text | References | PDF (370.1 KB) | EPUB | Supplemental
  • 182 Views
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Letter
A unique case of donor cell myeloma
Guillermo J. Ruiz-Argüelles, Alejandro Ruiz-Argüelles, Solón Javier Garcés-Eisele, Virginia Reyes-Nuñez, María Fernanda Vallejo-Villalobos & Gisela B. Gomez-Cruz
Pages: 1839-1841
Published online: 08 Jan 2019
First Page PreviewforA unique case of donor cell myeloma | Full Text | References | PDF (676.4 KB) | EPUB
  • 69 Views
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Letter
The utility of a telemedicine platform to monitor adherence and adverse effects of tyrosine kinase inhibitors
Anureet C. Copeland, Matthew C. Foster, Benyam Muluneh, James G. Xenakis, Anastasia Ivanova, Olga Frankfurt, Monique Clayton, Anderson Black, Barbara Rapchak & Robert S. Wehbie
Pages: 1842-1844
Published online: 18 Feb 2019
First Page PreviewforThe utility of a telemedicine platform to monitor adherence and adverse effects of tyrosine kinase inhibitors | Full Text | References | PDF (332.5 KB) | EPUB
  • 250 Views
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