Acta Oncologica, Volume 58, Issue 10 (2019)

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Acta Oncologica, Volume 58, Issue 10 (2019)

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18th Acta Oncologica symposium: BiGART2019 - Biology-Guided Adaptive Radiotherapy - Aarhus, Denmark - May 22-24, 2019

Editorial

Editorial
BIGART 2019 – adapting to the future
Jens Overgaard, Ludvig Paul Muren, Morten Høyer & Cai Grau
Pages: 1323-1327
Published online: 23 Oct 2019
First Page PreviewforBIGART 2019 – adapting to the future | Full Text | References | PDF (3.6 MB) | EPUB
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Commentaries

Article Commentary
Value-based health care – what does it mean for radiotherapy?
Yolande Lievens, Cai Grau & Ajay Aggarwal
Pages: 1328-1332
Published online: 05 Aug 2019
First Page PreviewforValue-based health care – what does it mean for radiotherapy? | Full Text | References | PDF (626.9 KB) | EPUB
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Article Commentary
Are Individual patient data meta-analyses still needed today in oncology? A discussion focused on Head and Neck oncology
Pierre Blanchard, Anne Aupérin & Jean-Pierre Pignon
Pages: 1333-1336
Published online: 03 Sep 2019
First Page PreviewforAre Individual patient data meta-analyses still needed today in oncology? A discussion focused on Head and Neck oncology | Full Text | References | PDF (376.1 KB) | EPUB
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Article Commentary
Commentary: RBE in proton therapy – where is the experimental in vivo data?
Brita Singers Sørensen
Pages: 1337-1339
Published online: 03 Oct 2019
First Page PreviewforCommentary: RBE in proton therapy – where is the experimental in vivo data? | Full Text | References | PDF (323 KB) | EPUB
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Letter to the Editor

Letter
Bringing Europe together in building clinical evidence for proton therapy – the EPTN–ESTRO–EORTC endeavor
Damien C. Weber, Cai Grau, Pei S. Lim, Dietmar Georg & Yolande Lievens
Pages: 1340-1342
Published online: 26 Jun 2019
First Page PreviewforBringing Europe together in building clinical evidence for proton therapy – the EPTN–ESTRO–EORTC endeavor | Full Text | References | PDF (306.8 KB) | EPUB
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Review

Review
Emerging trends in the treatment of rectal cancer
Bruce D. Minsky
Pages: 1343-1351
Published online: 04 Jul 2019
AbstractforEmerging trends in the treatment of rectal cancer | Full Text | References | PDF (710 KB) | EPUB
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Original Articles

Article
First clinical experiences with a high field 1.5 T MR linac
Anders S. Bertelsen, Tine Schytte, Pia K. Møller, Faisal Mahmood, Hans L. Riis, Karina L. Gottlieb, Søren N. Agergaard, Lars Dysager, Olfred Hansen, Janne Gornitzka, Elisabeth Veldhuizen, Dean B. ODwyer, Rasmus L. Christiansen, Morten Nielsen, Henrik R. Jensen, Carsten Brink & Uffe Bernchou
Pages: 1352-1357
Published online: 26 Jun 2019
AbstractforFirst clinical experiences with a high field 1.5 T MR linac | Full Text | References | PDF (1,010.2 KB) | EPUB | Supplemental
  • 4057 Views
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Article
Radiation dose and pathological response in oesophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgery: a multi-institutional analysis
Melissa Thomas, Alicia S. Borggreve, Peter S. N. van Rossum, Christiaan Perneel, Johnny Moons, Elke Van Daele, Richard van Hillegersberg, Wei Deng, Piet Pattyn, Stella Mook, Tom Boterberg, Jelle P. Ruurda, Philippe Nafteux, Steven H. Lin & Karin Haustermans
Pages: 1358-1365
Published online: 21 Aug 2019
AbstractforRadiation dose and pathological response in oesophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgery: a multi-institutional analysis | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 1530 Views
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Article
Relationship between patient and physician-rated xerostomia and dose distribution to the oral cavity and salivary glands for head and neck cancer patients after radiotherapy
J. K. Kaae, L. Johnsen, C. R. Hansen, M. H. Kristensen, C. Brink & J. G. Eriksen
Pages: 1366-1372
Published online: 26 Jun 2019
AbstractforRelationship between patient and physician-rated xerostomia and dose distribution to the oral cavity and salivary glands for head and neck cancer patients after radiotherapy | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Osteoradionecrosis of the mandible after radiotherapy for head and neck cancer: risk factors and dose-volume correlations
S. Aarup-Kristensen, C. R. Hansen, L. Forner, C. Brink, J. G. Eriksen & J. Johansen
Pages: 1373-1377
Published online: 31 Jul 2019
AbstractforOsteoradionecrosis of the mandible after radiotherapy for head and neck cancer: risk factors and dose-volume correlations | Full Text | References | PDF (782.7 KB) | EPUB
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Article
Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
Rudi Apolle, Steffen Appold, Henk P. Bijl, Pierre Blanchard, Johan Bussink, Corinne Faivre-Finn, Jonathan Khalifa, Anne Laprie, Yolande Lievens, Indira Madani, Amandine Ruffier, Dirk de Ruysscher, Wouter van Elmpt & Esther G. C. Troost
Pages: 1378-1385
Published online: 04 Jul 2019
AbstractforInter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2121 Views
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Article
An investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer
Thomas Lacoppidan, Ivan R. Vogelius, Mette Pøhl, Malene Strange, Gitte F. Persson & Lotte Nygård
Pages: 1386-1392
Published online: 04 Jul 2019
AbstractforAn investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 1018 Views
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Article
The effect of tumor laterality on survival for non-small cell lung cancer patients treated with radiotherapy
Nicolai Jørgensen, Eric Leif Meline, Stefan Starup Jeppesen, Olfred Hansen, Morten Nielsen & Tine Schytte
Pages: 1393-1398
Published online: 04 Jul 2019
AbstractforThe effect of tumor laterality on survival for non-small cell lung cancer patients treated with radiotherapy | Full Text | References | PDF (971.2 KB) | EPUB
  • 1079 Views
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Article
Survival after stereotactic radiotherapy in patients with early-stage non-small cell lung cancer
Olfred Hansen, Charlotte Kristiansen, Morten Nielsen, Tine Schytte & Stefan Starup Jeppesen
Pages: 1399-1403
Published online: 04 Jul 2019
AbstractforSurvival after stereotactic radiotherapy in patients with early-stage non-small cell lung cancer | Full Text | References | PDF (810 KB) | EPUB
  • 1236 Views
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Article
45 GyRBE for group III orbital embryonal rhabdomyosarcoma
Daniel J. Indelicato, Ronny L. Rotondo, Raymond B. Mailhot Vega, Haruka Uezono, Scott Bradfield, Vibhuti Agarwal, Marinka L. Hol & Julie A. Bradley
Pages: 1404-1409
Published online: 18 Sep 2019
Abstractfor45 GyRBE for group III orbital embryonal rhabdomyosarcoma | Full Text | References | PDF (1.5 MB) | EPUB
  • 1983 Views
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Article
NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy
C. R. Hansen, J. Friborg, K. Jensen, E. Samsøe, L. Johnsen, R. Zukauskaite, C. Grau, C. Maare, J. Johansen, H. Primdahl, Å. Bratland, C. A. Kristensen, M Andersen, J. G. Eriksen, J. Overgaard & On Behalf of the DAHANCA Group
Pages: 1410-1415
Published online: 21 Aug 2019
AbstractforNTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2490 Views
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Article
Normal tissue complication probability models in plan evaluation of children with brain tumors referred to proton therapy
Camilla H. Stokkevåg, Daniel J. Indelicato, Klaus Herfarth, Henriette Magelssen, Morten E. Evensen, Maren Ugland, Terje Nordberg, Tove A. Nystad, Camilla Hægeland, Mirjam D. Alsaker, Kjetil Ulven, Jon E. Dale, Grete M. Engeseth, Camilla G. Boer, Laura Toussaint, Josefine S. Kornerup, Helge E. S. Pettersen, Marianne Brydøy, Petter Brandal & Ludvig P. Muren
Pages: 1416-1422
Published online: 31 Jul 2019
AbstractforNormal tissue complication probability models in plan evaluation of children with brain tumors referred to proton therapy | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2249 Views
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Article
Daily adaptive proton therapy – the key to innovative planning approaches for paranasal cancer treatments
Lena Nenoff, Michael Matter, Johanna Hedlund Lindmar, Damien Charles Weber, Antony John Lomax & Francesca Albertini
Pages: 1423-1428
Published online: 31 Jul 2019
AbstractforDaily adaptive proton therapy – the key to innovative planning approaches for paranasal cancer treatments | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 2687 Views
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Article
Evaluation of proton and photon dose distributions recalculated on 2D and 3D Unet-generated pseudoCTs from T1-weighted MR head scans
Sebastian Neppl, Guillaume Landry, Christopher Kurz, David C. Hansen, Ben Hoyle, Sophia Stöcklein, Max Seidensticker, Jochen Weller, Claus Belka, Katia Parodi & Florian Kamp
Pages: 1429-1434
Published online: 04 Jul 2019
AbstractforEvaluation of proton and photon dose distributions recalculated on 2D and 3D Unet-generated pseudoCTs from T1-weighted MR head scans | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2478 Views
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Article
Intensity modulated proton therapy plan generation in under ten seconds
Michael Matter, Lena Nenoff, Gabriel Meier, Damien C. Weber, Antony J. Lomax & Francesca Albertini
Pages: 1435-1439
Published online: 04 Jul 2019
AbstractforIntensity modulated proton therapy plan generation in under ten seconds | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2429 Views
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Article
Plan-library supported automated replanning for online-adaptive intensity-modulated proton therapy of cervical cancer
Thyrza Z. Jagt, Sebastiaan Breedveld, Rens van Haveren, Remi A. Nout, Eleftheria Astreinidou, Ben J. M. Heijmen & Mischa S. Hoogeman
Pages: 1440-1445
Published online: 04 Jul 2019
AbstractforPlan-library supported automated replanning for online-adaptive intensity-modulated proton therapy of cervical cancer | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1957 Views
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Article
A theoretical investigation of adequate range uncertainty margins in proton treatment planning to preserve tumor control probability
Vicki T. Taasti, Jeho Jeong, Andrew Jackson & Joseph O. Deasy
Pages: 1446-1450
Published online: 26 Jun 2019
AbstractforA theoretical investigation of adequate range uncertainty margins in proton treatment planning to preserve tumor control probability | Full Text | References | PDF (561.3 KB) | EPUB | Supplemental
  • 763 Views
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Article
Towards proton arc therapy: physical and biologically equivalent doses with increasing number of beams in pediatric brain irradiation
Laura Toussaint, Daniel J. Indelicato, Katrine S. Holgersen, Jørgen B. B. Petersen, Camilla H. Stokkevåg, Yasmin Lassen-Ramshad, Oscar Casares-Magaz, Anne Vestergaard & Ludvig P. Muren
Pages: 1451-1456
Published online: 15 Jul 2019
AbstractforTowards proton arc therapy: physical and biologically equivalent doses with increasing number of beams in pediatric brain irradiation | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1930 Views
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Article
Radiation doses to brain substructures associated with cognition in radiotherapy of pediatric brain tumors
Laura Toussaint, Daniel J. Indelicato, Camilla H. Stokkevåg, Yasmin Lassen-Ramshad, Catia Pedro, Ronni Mikkelsen, Marcos Di Pinto, Zuofeng Li, Stella Flampouri, Anne Vestergaard, Jørgen B. B. Petersen, Henrik Schrøder, Morten Høyer & Ludvig P. Muren
Pages: 1457-1462
Published online: 04 Jul 2019
AbstractforRadiation doses to brain substructures associated with cognition in radiotherapy of pediatric brain tumors | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2415 Views
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Article
Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates
Steven van de Water, Sairos Safai, Jacobus M. Schippers, Damien C. Weber & Antony J. Lomax
Pages: 1463-1469
Published online: 26 Jun 2019
AbstractforTowards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 6820 Views
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Article
Towards a novel small animal proton irradiation platform: the SIRMIO project
Katia Parodi, Walter Assmann, Claus Belka, Jonathan Bortfeldt, Dirk-André Clevert, George Dedes, Ronaldo Kalunga, Sonja Kundel, Neeraj Kurichiyanil, Paulina Lämmer, Julie Lascaud, Kirsten Lauber, Giulio Lovatti, Sebastian Meyer, Munetaka Nitta, Marco Pinto, Mohammad J. Safari, Katrin Schnürle, Jörg Schreiber, Peter G. Thirolf, Hans-Peter Wieser & Matthias Würl
Pages: 1470-1475
Published online: 04 Jul 2019
AbstractforTowards a novel small animal proton irradiation platform: the SIRMIO project | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 2552 Views
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Article
Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes
Morten Busk, Michael R. Horsman, Jens Overgaard & Steen Jakobsen
Pages: 1476-1482
Published online: 21 Aug 2019
AbstractforDual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1101 Views
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Article
Dual-energy material decomposition for cone-beam computed tomography in image-guided radiotherapy
Mikkel Skaarup, Jens M. Edmund, Sabrina Dorn, Marc Kachelriess & Ivan R. Vogelius
Pages: 1483-1488
Published online: 04 Jul 2019
AbstractforDual-energy material decomposition for cone-beam computed tomography in image-guided radiotherapy | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1954 Views
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Article
Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts
Jacob Kinggaard Lilja-Fischer, Benedicte Parm Ulhøi, Jan Alsner, Magnus Stougaard, Mette Skovhus Thomsen, Morten Busk, Pernille Lassen, Torben Steiniche, Viveque Egsgaard Nielsen & Jens Overgaard
Pages: 1489-1494
Published online: 11 Sep 2019
AbstractforCharacterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1969 Views
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Article
A prospective, multicenter DAHANCA study of hyperfractionated, accelerated radiotherapy for head and neck squamous cell carcinoma
Mette Saksø, Elo Andersen, Jens Bentzen, Maria Andersen, Jørgen Johansen, Hanne Primdahl, Jens Overgaard & Jesper Grau Eriksen
Pages: 1495-1501
Published online: 13 Sep 2019
AbstractforA prospective, multicenter DAHANCA study of hyperfractionated, accelerated radiotherapy for head and neck squamous cell carcinoma | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 2996 Views
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Letters to the Editor

Letter
DAHANCA 9 – a randomized multicenter study to compare accelerated normo-fractionated radiotherapy with accelerated hyperfractionated radiotherapy in patients with primary squamous cell carcinoma of the head and neck (HNSCC)
Jan Folkvard Evensen, Hanne Sand Hansen, Marie Overgaard, Jørgen Johansen, Lisbeth Juhler Andersen & Jens Overgaard
Pages: 1502-1505
Published online: 08 Jul 2019
First Page PreviewforDAHANCA 9 – a randomized multicenter study to compare accelerated normo-fractionated radiotherapy with accelerated hyperfractionated radiotherapy in patients with primary squamous cell carcinoma of the head and neck (HNSCC) | Full Text | References | PDF (709 KB) | EPUB
  • 1880 Views
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Letter
Distinguishing recurrence and new primary tumor as well as the origin of neck metastases in head and neck cancer clinical trials by targeted DNA sequencing
Jacob Kinggaard Lilja-Fischer, Mette Saksø, Magnus Stougaard, Torben Steiniche & Jens Overgaard
Pages: 1506-1508
Published online: 04 Jul 2019
First Page PreviewforDistinguishing recurrence and new primary tumor as well as the origin of neck metastases in head and neck cancer clinical trials by targeted DNA sequencing | Full Text | References | PDF (613.3 KB) | EPUB
  • 1366 Views
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Letter
Subglottic squamous cell carcinoma in Denmark 1971–2015 – a national population-based cohort study from DAHANCA, the Danish Head and Neck Cancer group
Louise Hill-Madsen, Claus A. Kristensen, Elo Andersen, Jørgen Johansen, Lisbeth J. Andersen, Hanne Primdahl, Jens Overgaard & Nina M. Lyhne
Pages: 1509-1513
Published online: 31 Jul 2019
First Page PreviewforSubglottic squamous cell carcinoma in Denmark 1971–2015 – a national population-based cohort study from DAHANCA, the Danish Head and Neck Cancer group | Full Text | References | PDF (1.4 MB) | EPUB
  • 1023 Views
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Letter
Perfusion CT radiomics as potential prognostic biomarker in head and neck squamous cell carcinoma
M. Bogowicz, S. Tanadini-Lang, P. Veit-Haibach, M. Pruschy, S. Bender, A. Sharma, M. Hüllner, G. Studer, S. Stieb, H. Hemmatazad, S. Glatz, M. Guckenberger & O. Riesterer
Pages: 1514-1518
Published online: 14 Jul 2019
First Page PreviewforPerfusion CT radiomics as potential prognostic biomarker in head and neck squamous cell carcinoma | Full Text | References | PDF (776.7 KB) | EPUB | Supplemental
  • 1365 Views
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Letter
Analysis of lymphatic metastasis and progression patterns for clinical target volume (CTV) definition in head and neck squamous cell carcinoma (HNSCC)
B. Pouymayou, C. Koechli, P. Balermpas, M. Guckenberger & J. Unkelbach
Pages: 1519-1522
Published online: 31 Jul 2019
First Page PreviewforAnalysis of lymphatic metastasis and progression patterns for clinical target volume (CTV) definition in head and neck squamous cell carcinoma (HNSCC) | Full Text | References | PDF (743.2 KB) | EPUB | Supplemental
  • 1101 Views
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Letter
Patient-reported lung symptoms and quality of life before and after radiation therapy for non-small cell lung cancer: correlation with radiation pneumonitis and functional imaging
Katherina P. Farr, Azza A. Khalil & Cai Grau
Pages: 1523-1527
Published online: 18 Jul 2019
First Page PreviewforPatient-reported lung symptoms and quality of life before and after radiation therapy for non-small cell lung cancer: correlation with radiation pneumonitis and functional imaging | Full Text | References | PDF (735.4 KB) | EPUB | Supplemental
  • 1531 Views
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Letter
Factors determining the effect of prophylactic cranial irradiation (PCI) in patients with stage-III nonsmall cell lung cancer: exploratory subgroup analyses of the NVALT-11/DLCRG-02 phase-III study
W. J. A. Witlox, B. L. T. Ramaekers, H. J. M. Groen, A. M. Dingemans, J. Praag, J. Belderbos, V. van der Noort, H. van Tinteren, M. A. Joore & D. K. M. De Ruysscher
Pages: 1528-1531
Published online: 01 Jul 2019
First Page PreviewforFactors determining the effect of prophylactic cranial irradiation (PCI) in patients with stage-III nonsmall cell lung cancer: exploratory subgroup analyses of the NVALT-11/DLCRG-02 phase-III study | Full Text | References | PDF (669.7 KB) | EPUB | Supplemental
  • 984 Views
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Letter
Individualizing the radiotherapy target volume for glioblastoma using DTI-MRI: a phase 0 study on coverage of recurrences
Anouk K. Trip, Morten B. Jensen, Jesper F. Kallehauge & Slavka Lukacova
Pages: 1532-1535
Published online: 15 Jul 2019
First Page PreviewforIndividualizing the radiotherapy target volume for glioblastoma using DTI-MRI: a phase 0 study on coverage of recurrences | Full Text | References | PDF (691.3 KB) | EPUB | Supplemental
  • 1501 Views
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Letter
Predicting late magnetic resonance image changes in glioma patients after proton therapy
J. Eulitz, E.G.C. Troost, F. Raschke, E. Schulz, B. Lutz, A. Dutz, S. Löck, P. Wohlfahrt, W. Enghardt, C. Karpowitz, M. Krause & A. Lühr
Pages: 1536-1539
Published online: 15 Jul 2019
First Page PreviewforPredicting late magnetic resonance image changes in glioma patients after proton therapy | Full Text | References | PDF (999.5 KB) | EPUB | Supplemental
  • 2350 Views
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Letter
Initial experiences with hippocampus-sparing whole-brain radiotherapy for lung cancer patients
M. Nielsen, C. Kristiansen, T. Schytte & O. Hansen
Pages: 1540-1542
Published online: 15 Jul 2019
First Page PreviewforInitial experiences with hippocampus-sparing whole-brain radiotherapy for lung cancer patients | Full Text | References | PDF (650.3 KB) | EPUB
  • 1012 Views
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Letter
High accumulated doses to the inferior rectum are associated with late gastro-intestinal toxicity in a case-control study of prostate cancer patients treated with radiotherapy
Oscar Casares-Magaz, Steffen Bülow, Niclas J. Pettersson, Vitali Moiseenko, Jesper Pedersen, Maria Thor, John Einck, Austin Hopper, Rick Knopp & Ludvig Paul Muren
Pages: 1543-1546
Published online: 31 Jul 2019
First Page PreviewforHigh accumulated doses to the inferior rectum are associated with late gastro-intestinal toxicity in a case-control study of prostate cancer patients treated with radiotherapy | Full Text | References | PDF (866.9 KB) | EPUB | Supplemental
  • 1065 Views
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