Pharmaceutical Development and Technology, Volume 4, Issue 4 (1999)

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Pharmaceutical Development and Technology, Volume 4, Issue 4 (1999)

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Research Article

Article
Optimization of Sustained-Release Tablet Formulations: A Four-Component Mixture Experiment
Madhusudan Hariharan
Pages: 39-60
Published online: 20 Oct 1999
CitationforOptimization of Sustained-Release Tablet Formulations: A Four-Component Mixture Experiment | Full Text | References | PDF (17 KB)
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Article
The Effect of Humidity on Samples of Microcrystalline Cellulose Taken From the Extrusion/Marumerization Process
Francis C. Mayville, Faraj Atassi, Rodney J. Wigent & Joseph B. Schwartz
Pages: 467-474
Published online: 20 Oct 1999
AbstractforThe Effect of Humidity on Samples of Microcrystalline Cellulose Taken From the Extrusion/Marumerization Process | Full Text | References | PDF (112.8 KB)
  • 99 Views
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Article
Developing an Injectable Formula Containing an Oxygen-Sensitive Drug: A Case Study of Danofloxacin Injectable
Kasra Kasraian, Anna A. Kuzniar, Gabrielle G. Wilson & Julia A. Wood
Pages: 475-480
Published online: 20 Oct 1999
AbstractforDeveloping an Injectable Formula Containing an Oxygen-Sensitive Drug: A Case Study of Danofloxacin Injectable | Full Text | References | PDF (96.8 KB)
  • 422 Views
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Article
Drug Release from Film-Coated Chlorpheniramine Maleate Nonpareil Beads: Water Influx and Development of a New Drug Release Model
Lijuan Tang, Rodney J. Wigent & Joseph B. Schwartz
Pages: 481-490
Published online: 20 Oct 1999
AbstractforDrug Release from Film-Coated Chlorpheniramine Maleate Nonpareil Beads: Water Influx and Development of a New Drug Release Model | Full Text | References | PDF (329.6 KB)
  • 79 Views
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Article
Stability of Poly(l-Lysine)-Complexed Plasmid DNA During Mechanical Stress and DNase I Treatment
Yilmaz Capan, Byung H. Woo, Sisay Gebrekidan, Shamim Ahmed & Patrick P. DeLuca
Pages: 491-498
Published online: 20 Oct 1999
AbstractforStability of Poly(l-Lysine)-Complexed Plasmid DNA During Mechanical Stress and DNase I Treatment | Full Text | References | PDF (244 KB)
  • 169 Views
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Article
Formulation of Ranitidine Pellets by Extrusion-Spheronization with Little or No Microcrystalline Cellulose
Abdul W. Basit, J. Michael Newton & Larry F. Lacey
Pages: 499-505
Published online: 20 Oct 1999
AbstractforFormulation of Ranitidine Pellets by Extrusion-Spheronization with Little or No Microcrystalline Cellulose | Full Text | References | PDF (97.6 KB)
  • 313 Views
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Article
The Preparation of Soft Gelatin Capsules for a Radioactive Tracer Study
Marc S. Tesconi, Steven L. Bramer & Samuel H. Yalkowsky
Pages: 507-513
Published online: 20 Oct 1999
AbstractforThe Preparation of Soft Gelatin Capsules for a Radioactive Tracer Study | Full Text | References | PDF (303.9 KB)
  • 116 Views
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Article
In Vitro Properties of an In Situ Forming Gel for the Parenteral Delivery of Macromolecular Drugs*
Rajashree Joshi, Dennis H. Robinson & Kenneth J. Himmelstein
Pages: 515-522
Published online: 20 Oct 1999
AbstractforIn Vitro Properties of an In Situ Forming Gel for the Parenteral Delivery of Macromolecular Drugs* | Full Text | References | PDF (116.8 KB)
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Article
Dry Plant Extracts Loaded on Fumed Silica for Direct Compression: Preparation and Preformulation
Santiago D. Palma, Ruben H. Manzo & Daniel A. Allemandi
Pages: 523-530
Published online: 20 Oct 1999
AbstractforDry Plant Extracts Loaded on Fumed Silica for Direct Compression: Preparation and Preformulation | Full Text | References | PDF (493.9 KB)
  • 95 Views
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Article
Starch Gelatinization Under Thermal Stress
Damrongsak Faroongsarng, Wibul Wongpoowarak & Ampol Mitrevej
Pages: 531-538
Published online: 20 Oct 1999
AbstractforStarch Gelatinization Under Thermal Stress | Full Text | References | PDF (123.8 KB)
  • 63 Views
  • 3 CrossRef citations
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Article
Enzymatic Degradation of Leuprolide in Rat Intestinal Mucosal Homogenates
Yuqun Zheng, Y. Jack Zheng, Mou-ying FuLu, Yihong Qiu & Thomas L. Reiland
Pages: 539-544
Published online: 20 Oct 1999
AbstractforEnzymatic Degradation of Leuprolide in Rat Intestinal Mucosal Homogenates | Full Text | References | PDF (101.4 KB)
  • 81 Views
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Article
A Novel Percolation Method for Determining Solubilities of Pharmaceutical Agents in Semisolid Vehicles
Michael Spangler & David Harris
Pages: 545-552
Published online: 20 Oct 1999
AbstractforA Novel Percolation Method for Determining Solubilities of Pharmaceutical Agents in Semisolid Vehicles | Full Text | References | PDF (94 KB)
  • 47 Views
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Article
Development and Evaluation of a Laboratory-Scale Apparatus to Simulate the Scale-Up of a Sterile Semisolid and Effects of Manufacturing Parameters on Product Viscosity
Pei-I Chu & Donald Doyle
Pages: 553-559
Published online: 20 Oct 1999
AbstractforDevelopment and Evaluation of a Laboratory-Scale Apparatus to Simulate the Scale-Up of a Sterile Semisolid and Effects of Manufacturing Parameters on Product Viscosity | Full Text | References | PDF (350.8 KB)
  • 123 Views
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Article
Mixed Polymer Coating for Modified Release from Coated Spheroids
Yvonne T. F. Tan, Paul W. S. Heng & Lucy S. C. Wan
Pages: 561-570
Published online: 20 Oct 1999
AbstractforMixed Polymer Coating for Modified Release from Coated Spheroids | Full Text | References | PDF (436.2 KB)
  • 74 Views
  • 7 CrossRef citations
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Article
The Effects of pH and Mixed Solvent Systems on the Solubility of Oxytetracycline
Sauwaluxana Tongaree Ph.D., Douglas R. Flanagan & Rolland I. Poust
Pages: 571-580
Published online: 20 Oct 1999
AbstractforThe Effects of pH and Mixed Solvent Systems on the Solubility of Oxytetracycline | Full Text | References | PDF (1 MB)
  • 291 Views
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Article
The Interaction Between Oxytetracycline and Divalent Metal Ions in Aqueous and Mixed Solvent Systems
Sauwaluxana Tongaree Ph.D., Douglas R. Flanagan & Rolland I. Poust
Pages: 581-591
Published online: 20 Oct 1999
AbstractforThe Interaction Between Oxytetracycline and Divalent Metal Ions in Aqueous and Mixed Solvent Systems | Full Text | References | PDF (279.6 KB)
  • 219 Views
  • 29 CrossRef citations
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Article
Modeling Methods for Mixture-of-Mixtures Experiments Applied to a Tablet Formulation Problem
Greg F. Piepel
Pages: 593-606
Published online: 20 Oct 1999
AbstractforModeling Methods for Mixture-of-Mixtures Experiments Applied to a Tablet Formulation Problem | Full Text | References | PDF (273.3 KB)
  • 103 Views
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Article
Recombinant Human Bone Morphogenetic Protein-2 Binding and Incorporation in PLGA Microsphere Delivery Systems
Jay A. Schrier & Patrick P. DeLuca
Pages: 611-621
Published online: 20 Oct 1999
AbstractforRecombinant Human Bone Morphogenetic Protein-2 Binding and Incorporation in PLGA Microsphere Delivery Systems | Full Text | References | PDF (405.7 KB)
  • 227 Views
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Article
Solid-State Phase Transitions of AG337, an Antitumor Agent
Suneel Rastogi, Irina Zamansky, Samir Roy, Praveen Tyle & Raj Suryanarayanan
Pages: 623-632
Published online: 20 Oct 1999
AbstractforSolid-State Phase Transitions of AG337, an Antitumor Agent | Full Text | References | PDF (169.4 KB)
  • 35 Views
  • 2 CrossRef citations
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Article
Stabilization of pH-Induced Degradation of Porcine Insulin in Biodegradable Polyester Microspheres
Pushpa G. Shao & Leonard C. Bailey
Pages: 633-642
Published online: 20 Oct 1999
AbstractforStabilization of pH-Induced Degradation of Porcine Insulin in Biodegradable Polyester Microspheres | Full Text | References | PDF (336.4 KB)
  • 127 Views
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