Pharmaceutical Development and Technology, Volume 5, Issue 3 (2000)

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Pharmaceutical Development and Technology, Volume 5, Issue 3 (2000)

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Research Article

Article
Influence of Peroxide Impurities in Povidone and Crospovidone on the Stability of Raloxifene Hydrochloride in Tablets: Identification and Control of an Oxidative Degradation Product
Kerry J. Hartauer, Gordon N. Arbuthnot, Steven W. Baertschi, Ross A. Johnson, Wayne D. Luke, Neil G. Pearson, Eugene C. Rickard, Cheryl A. Tingle, Paul K. S. Tsang & Robert E. Wiens
Pages: 303-310
Published online: 24 Jul 2000
AbstractforInfluence of Peroxide Impurities in Povidone and Crospovidone on the Stability of Raloxifene Hydrochloride in Tablets: Identification and Control of an Oxidative Degradation Product | Full Text | References | PDF (109.5 KB)
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Article
The Prediction of Variability Occurring in Fluidized Bed Coating Equipment. I. The Measurement of Particle Circulation Rates in a Bottom-Spray Fluidized Bed Coater
X. X. Cheng & R. Turton
Pages: 311-322
Published online: 24 Jul 2000
AbstractforThe Prediction of Variability Occurring in Fluidized Bed Coating Equipment. I. The Measurement of Particle Circulation Rates in a Bottom-Spray Fluidized Bed Coater | Full Text | References | PDF (165.4 KB)
  • 302 Views
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Article
The Prediction of Variability Occurring in Fluidized Bed Coating Equipment. II. The Role of Nonuniform Particle Coverage as Particles Pass Through the Spray Zonemr
X. X. Cheng & R. Turton
Pages: 323-332
Published online: 24 Jul 2000
AbstractforThe Prediction of Variability Occurring in Fluidized Bed Coating Equipment. II. The Role of Nonuniform Particle Coverage as Particles Pass Through the Spray Zonemr | Full Text | References | PDF (183.5 KB)
  • 158 Views
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Article
Development and Testing of an Improved Parenteral Formulation of Phenytoin Using 2-Hydroxypropyl-β-cyclodextrin
J. Blanchard, S. O. Ugwu, R. Bhardwaj & R. T. Dorr
Pages: 333-338
Published online: 24 Jul 2000
AbstractforDevelopment and Testing of an Improved Parenteral Formulation of Phenytoin Using 2-Hydroxypropyl-β-cyclodextrin | Full Text | References | PDF (114.1 KB)
  • 229 Views
  • 12 CrossRef citations
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Article
Evaluation of High Molecular Weight Poly(Oxyethylene) (Polyox) Polymer: Studies of Flow Properties and Release Rates of Furosemide and Captopril from Controlled-Release Hard Gelatin Capsules
M. Efentakis & M. Vlachou
Pages: 339-346
Published online: 24 Jul 2000
AbstractforEvaluation of High Molecular Weight Poly(Oxyethylene) (Polyox) Polymer: Studies of Flow Properties and Release Rates of Furosemide and Captopril from Controlled-Release Hard Gelatin Capsules | Full Text | References | PDF (114.7 KB)
  • 216 Views
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Article
Formulation and Evaluation of Vinylpyrrolidone/Vinylacetate Copolymer Microspheres with Carbamazepine
Mariarosa Moneghini, Dario Voinovich, Francesco Princivalle & Lorenzo Magarotto
Pages: 347-353
Published online: 24 Jul 2000
AbstractforFormulation and Evaluation of Vinylpyrrolidone/Vinylacetate Copolymer Microspheres with Carbamazepine | Full Text | References | PDF (633.8 KB)
  • 78 Views
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Article
Temperature- and Moisture-Induced Crystallization of Amorphous Lactose in Composite Particles with Sodium Alginate Prepared by Spray-Drying
Hirofumi Takeuchi, Takehiko Yasuji, Hiromitsu Yamamoto & Yoshiaki Kawashima
Pages: 355-363
Published online: 24 Jul 2000
AbstractforTemperature- and Moisture-Induced Crystallization of Amorphous Lactose in Composite Particles with Sodium Alginate Prepared by Spray-Drying | Full Text | References | PDF (553.9 KB)
  • 235 Views
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Article
Scaleup of a High-Shear Granulation Process Using a Normalized Impeller Work Parameter
Paul J. Sirois & Gordon D. Craig
Pages: 365-374
Published online: 24 Jul 2000
AbstractforScaleup of a High-Shear Granulation Process Using a Normalized Impeller Work Parameter | Full Text | References | PDF (151.4 KB)
  • 285 Views
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Article
Modulation of Drug Release Rate of Diltiazem–HCl from Hydrogel Matrices of Succinic Acid-Treated Ispaghula Husk
Mukesh C. Gohel, Avani F. Amin, Mahesh T. Chhabaria, Maulik K. Panchal & Anita N. Lalwani
Pages: 375-381
Published online: 24 Jul 2000
AbstractforModulation of Drug Release Rate of Diltiazem–HCl from Hydrogel Matrices of Succinic Acid-Treated Ispaghula Husk | Full Text | References | PDF (96.4 KB)
  • 53 Views
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Article
Drug Release from Film-Coated Chlorpheniramine Maleate Nonpareil Beads: Effect of Water-Soluble Polymer, Coating Level, and Soluble Core Material
Lijuan Tang, Joseph B. Schwartz, Stuart C. Porter, Roger L. Schnaare & Rodney J. Wigent
Pages: 383-390
Published online: 24 Jul 2000
AbstractforDrug Release from Film-Coated Chlorpheniramine Maleate Nonpareil Beads: Effect of Water-Soluble Polymer, Coating Level, and Soluble Core Material | Full Text | References | PDF (119.2 KB)
  • 237 Views
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Article
In Situ Gel Formulations for Gene Delivery: Release and Myotoxicity Studies
Fatma A. Ismail Ph.D., Jintana Napaporn, Jeffrey A. Hughes Ph.D. & Gayle A. Brazeau Ph.D.
Pages: 391-397
Published online: 24 Jul 2000
AbstractforIn Situ Gel Formulations for Gene Delivery: Release and Myotoxicity Studies | Full Text | References | PDF (139.2 KB)
  • 93 Views
  • 33 CrossRef citations
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Article
Improvement of Solubility and Oral Bioavailability of Rutin by Complexation with 2-Hydroxypropyl-β-cyclodextrin
Kouzou Miyake, Hidetoshi Arima, Fumitoshi Hirayama, Masanobu Yamamoto, Takashi Horikawa, Hideyuki Sumiyoshi, Shuji Noda & Kaneto Uekama
Pages: 399-407
Published online: 24 Jul 2000
AbstractforImprovement of Solubility and Oral Bioavailability of Rutin by Complexation with 2-Hydroxypropyl-β-cyclodextrin | Full Text | References | PDF (140.6 KB)
  • 460 Views
  • 89 CrossRef citations
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Article
Permeability of Chemical Delivery Systems Across Rabbit Corneal (SIRC) Cell Line and Isolated Corneas: A Comparative Study
Venkat R. Goskonda, Ronald A. Hill, Mansoor A. Khan & Indra K. Reddy
Pages: 409-416
Published online: 24 Jul 2000
AbstractforPermeability of Chemical Delivery Systems Across Rabbit Corneal (SIRC) Cell Line and Isolated Corneas: A Comparative Study | Full Text | References | PDF (102.9 KB)
  • 104 Views
  • 27 CrossRef citations
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Article
Stability of Luteinizing Hormone Releasing Hormone: Effects of pH, Temperature, Pig Skin, and Enzyme Inhibitors
Mingda Bi & Jagdish Singh
Pages: 417-422
Published online: 24 Jul 2000
AbstractforStability of Luteinizing Hormone Releasing Hormone: Effects of pH, Temperature, Pig Skin, and Enzyme Inhibitors | Full Text | References | PDF (104.8 KB)
  • 79 Views
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Article
Communicating Tabular Data Using ORACLE
Anil Menon & Nadhamuni Nerella
Pages: 423-431
Published online: 24 Jul 2000
AbstractforCommunicating Tabular Data Using ORACLE | Full Text | References | PDF (104.5 KB)
  • 18 Views
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Article
Applying Image Analysis in the Observation of Recrystallization of Amorphous Cefadroxil
Satu Parkkali, Vesa -Pekka Lehto & Ensio Laine
Pages: 433-438
Published online: 24 Jul 2000
First Page PreviewforApplying Image Analysis in the Observation of Recrystallization of Amorphous Cefadroxil | Full Text | References | PDF (669.6 KB)
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