Toxicology Mechanisms and Methods, Volume 18, Issue 2-3 (2008)

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Toxicology Mechanisms and Methods, Volume 18, Issue 2-3 (2008)

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EDITORIAL

Editorial
Computational Toxicology
Luis G. Valerio Jr. Ph.D. & Rakesh Dixit Ph.D., D.A.B.T.
Pages: 97-99
Published online: 09 Oct 2008
First Page PreviewforComputational Toxicology | Full Text | PDF (46.5 KB)
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Foreword

Foreword
Joseph F. Contrera Ph.D.
Page: 101
Published online: 09 Oct 2008
CitationforForeword | Full Text | PDF (33.1 KB)
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Review

Review Article
Toxicity Data Informatics: Supporting a New Paradigm for Toxicity Prediction
Ann M. Richard, Chihae Yang & Richard S. Judson
Pages: 103-118
Published online: 09 Oct 2008
AbstractforToxicity Data Informatics: Supporting a New Paradigm for Toxicity Prediction | Full Text | References | PDF (5 MB)
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Review Article
Computational Toxicology Methods in Public Health Practice
Eugene Demchuk, Patricia Ruiz, Jewell D. Wilson, Franco Scinicariello, Hana R. Pohl, Mike Fay, Moiz M. Mumtaz, Hugh Hansen & Christopher T. De Rosa
Pages: 119-135
Published online: 09 Oct 2008
AbstractforComputational Toxicology Methods in Public Health Practice | Full Text | References | PDF (732.4 KB)
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Review Article
Predictivity and Reliability of QSAR Models: The Case of Mutagens and Carcinogens
Romualdo Benigni & Cecilia Bossa
Pages: 137-147
Published online: 09 Oct 2008
AbstractforPredictivity and Reliability of QSAR Models: The Case of Mutagens and Carcinogens | Full Text | References | PDF (153.3 KB)
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Review Article
The Use of (Q)SAR Methods in the Context of REACH
Uwe Lahl & Ursula Gundert-Remy
Pages: 149-158
Published online: 09 Oct 2008
AbstractforThe Use of (Q)SAR Methods in the Context of REACH | Full Text | References | PDF (117.7 KB)
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Review Article
MultiCASE Expert Systems and the REACH Initiative
Roustem D. Saiakhov & Gilles Klopman
Pages: 159-175
Published online: 09 Oct 2008
AbstractforMultiCASE Expert Systems and the REACH Initiative | Full Text | References | PDF (1.4 MB)
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Review Article
In Silico Tools for Sharing Data and Knowledge on Toxicity and Metabolism: Derek for Windows, Meteor, and Vitic
Carol A. Marchant, Katharine A. Briggs & Anthony Long
Pages: 177-187
Published online: 09 Oct 2008
AbstractforIn Silico Tools for Sharing Data and Knowledge on Toxicity and Metabolism: Derek for Windows, Meteor, and Vitic | Full Text | References | PDF (2 MB)
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Research Article

Article
Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action–Based Predictions of Chemical Carcinogenesis in Rodents
Edwin J. Matthews, Naomi L. Kruhlak, R. Daniel Benz, Joseph F. Contrera, Carol A. Marchant & Chihae Yang
Pages: 189-206
Published online: 09 Oct 2008
AbstractforCombined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action–Based Predictions of Chemical Carcinogenesis in Rodents | Full Text | References | PDF (156.9 KB)
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Article
In Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors
Joseph F. Contrera, Edwin J. Matthews, Naomi L. Kruhlak & R. Daniel Benz
Pages: 207-216
Published online: 09 Oct 2008
AbstractforIn Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors | Full Text | References | PDF (106.9 KB)
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Article
Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models
Naomi L. Kruhlak, Sydney S. Choi, Joseph F. Contrera, James L. Weaver, James M. Willard, Kenneth L. Hastings & Lawrence F. Sancilio
Pages: 217-227
Published online: 09 Oct 2008
AbstractforDevelopment of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models | Full Text | References | PDF (1.5 MB)
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Article
In Silico Toxicological Screening of Natural Products
Kirk B. Arvidson, Luis G. Valerio Jr., Marilyn Diaz & Ronald F. Chanderbhan
Pages: 229-242
Published online: 09 Oct 2008
AbstractforIn Silico Toxicological Screening of Natural Products | Full Text | References | PDF (229.5 KB)
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Article
Combined Computational Metabolite Prediction and Automated Structure-Based Analysis of Mass Spectrometric Data
David D. Stranz, Shichang Miao, Scott Campbell, George Maydwell & Sean Ekins
Pages: 243-250
Published online: 09 Oct 2008
AbstractforCombined Computational Metabolite Prediction and Automated Structure-Based Analysis of Mass Spectrometric Data | Full Text | References | PDF (1.7 MB)
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Article
A Hierarchical Clustering Methodology for the Estimation of Toxicity
Todd M. Martin, Paul Harten, Raghuraman Venkatapathy, Shashikala Das & Douglas M. Young
Pages: 251-266
Published online: 09 Oct 2008
AbstractforA Hierarchical Clustering Methodology for the Estimation of Toxicity | Full Text | References | PDF (397.3 KB)
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Article
Characteristics of Genomic Signatures Derived Using Univariate Methods and Mechanistically Anchored Functional Descriptors for Predicting Drug- and Xenobiotic-Induced Nephrotoxicity
Weiwei Shi, Andrej Bugrim, Yuri Nikolsky, Tatiana Nikolskya & Richard J. Brennan
Pages: 267-276
Published online: 09 Oct 2008
AbstractforCharacteristics of Genomic Signatures Derived Using Univariate Methods and Mechanistically Anchored Functional Descriptors for Predicting Drug- and Xenobiotic-Induced Nephrotoxicity | Full Text | References | PDF (2.5 MB)
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Article
Understanding Genetic Toxicity Through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases
C. Yang, C. H. Hasselgren, S. Boyer, K. Arvidson, S. Aveston, P. Dierkes, R. Benigni, R. D. Benz, J. Contrera, N. L. Kruhlak, E. J. Matthews, X. Han, J. Jaworska, R. A. Kemper, J. F. Rathman & A. M. Richard
Pages: 277-295
Published online: 09 Oct 2008
AbstractforUnderstanding Genetic Toxicity Through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases | Full Text | References | PDF (7.6 MB)
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Appendix for Special Issue on Computational Toxicology

Appendix for Special Issue on Computational Toxicology
Pages: 297-300
Published online: 09 Oct 2008
First Page PreviewforAppendix for Special Issue on Computational Toxicology | Full Text | PDF (41 KB)
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