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‘Latest articles’ are articles accepted for publication in this journal but not yet published in a volume/issue. Articles are removed from the ‘Latest articles’ list when they are published in a volume/issue. Latest articles are citable using the author(s), year of online publication, article title, journal and article DOI.

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RESEARCH ARTICLE

Article
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers
Meghan E. Gray, Karina M. Zielinski, Fanny Xu, Kayla K. Elder, Steven J. McKay, Victor T. Ojo, Samantha R. Benjamin, Aiman A. Yaseen, Tracy A. Brooks & L. Nathan Tumey
Accepted author version posted online: 13 May 2024
  • 48 Views
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Review Article

Review Article
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Michael Z. Liao, Douglas D. Leipold, Shang-Chiung Chen, Zao Li, Amrita V. Kamath & Chunze Li
Accepted author version posted online: 13 May 2024
  • 203 Views
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Review Article

Review Article
Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs
Qihong Huang, Minu Ravindra Pilvankar, Rakesh Dixit & Hongbin Yu
Accepted author version posted online: 11 May 2024
  • 72 Views
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Review Article

Review Article
Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?
Maria Luisa Sardu & Italo Poggesi
Accepted author version posted online: 30 Apr 2024
  • 16 Views
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Animal Pharmacokinetics and Metabolism

Article
Developmental stage and infection status may affect drug distribution in the prostate of rats
Ziyang Xu, Lianzhan Sun, Chang Yin, Handa Wu, Xue Wang, Yunyun Yang & Zhuo Wang
Published online: 25 Apr 2024
  • 34 Views
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General Xenobiochemistry

Article
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle
Paula Ichinose, María Victoria Miró, Paula Viviani, Juan Manuel Herrera, Adrián Lifschitz & Guillermo Virkel
Published online: 25 Apr 2024
  • 63 Views
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General Xenobiochemistry

Article
mRNA expression levels of cytochrome P450 CYP1A2, CYP3A4, and CYP3A5 in the epidermis: a focus on individual differences among Japanese individuals
Hiroko Makihara, Mika Maezawa, Kazusa Kaiga, Toshihiko Satake, Mayu Muto, Yui Tsunoda, Tsutomu Shimada & Tomoko Akase
Published online: 24 Apr 2024
  • 59 Views
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Commentary

Rapid Communication
Academic foreign compound metabolism – ‘quo vadis’?
S. C. Mitchell & R. H. Waring
Published online: 24 Apr 2024
  • 131 Views
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Open Access

RESEARCH ARTICLE

Article
Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species
Victor Yip, Ola M. Saad, Doug Leipold, Chunze Li, Amrita Kamath & Ben-Quan Shen
Accepted author version posted online: 22 Apr 2024
  • 496 Views
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Open Access

Animal Pharmacokinetics and Metabolism

Article
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain
Danqing Wu, Rui Luo, Yangnan Chen, Zhiyun Zheng, Shuangying Gui & Ning He
Published online: 19 Apr 2024
  • 10 Views
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Research Article

Article
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophages
Chen-Chung Lin, Brandon F. Law & Justin M. Hettick
Published online: 19 Apr 2024
  • 127 Views
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RESEARCH ARTICLE

Article
Selection of a Suitable Animal Model to Evaluate Secretion of Drugs in the Human Milk: A Systematic Approach
Riya Nilkant, Chintha Kathiresan, Namrata Kumar, Steve Caritis, Imam H. Shaik & Raman Venkataramanan
Accepted author version posted online: 18 Apr 2024
  • 50 Views
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Review Article

Review Article
Bioanalytical Approaches to Support the Development of Antibody-Oligonucleotide Conjugate (AOC) Therapeutic Proteins
Anthony Murphy, Ryan Hill & Michael Berna
Accepted author version posted online: 12 Apr 2024
  • 184 Views
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General Xenobiochemistry

Article
Assessment of cytochrome P450 induction in canine intestinal organoid models
Itsuma Nagao, Meg Nakazawa, Takashi Goyama, Michael H. Court & Yoko M. Ambrosini
Published online: 13 Mar 2024
  • 619 Views
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Open Access

RESEARCH ARTICLE

Article
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury
Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu & Kouichi Yoshinari
Accepted author version posted online: 05 Feb 2024
  • 89 Views
  • 0 CrossRef citations
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Review Article

Review Article
Meeting report of the 4th European biotransformation workshop
M. Walles, A. Pähler, E.M. Isin & Marie M. Ahlqvist
Published online: 04 Jan 2024
  • 188 Views
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Review Article

Review Article
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science.
Dennis A Smith, Lucy Melanie Burton & Sophie Amanda
Accepted author version posted online: 14 Dec 2023
  • 51 Views
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SPECIAL ISSUE

Review Article
The history and future of population pharmacokinetic analysis in drug development
Nathan Teuscher
Accepted author version posted online: 05 Dec 2023
  • 100 Views
  • 0 CrossRef citations
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RESEARCH ARTICLE

Article
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry
Seo-jin Park, Jeong-hyeon Lim, Jiyu Lee, Jeongmin Lee, Sangsoo Hwang, Hyunjin Kim, Seunghyun Jo, Duckhyang Shin, Sang Ho MA, Myung L. Kim & Young G. Shin
Accepted author version posted online: 16 Nov 2023
  • 56 Views
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RESEARCH ARTICLE

Article
Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning
Mario Öeren, Peter A. Hunt, Charlotte E. Wharrick, Hamed Tabatabaei Ghomi & Matthew D. Segall
Accepted author version posted online: 15 Nov 2023
  • 145 Views
  • 1 CrossRef citations
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Review Article

Review Article
In silico ADME/tox comes of age: twenty years later
Sean Ekins, Thomas R. Lane, Fabio Urbina & Ana C. Puhl
Published online: 08 Aug 2023
  • 417 Views
  • 1 CrossRef citations
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