Xenobiotica, Volume 18, Issue 5 (1988)

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Xenobiotica, Volume 18, Issue 5 (1988)

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Original Article

Article
Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine
T. Baba, H. Yamada, K. Oguri & H. Yoshimura
Pages: 475-484
Published online: 30 Sep 2009
AbstractforParticipation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine | References | PDF (1.3 MB)
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Article
Artifacts in the determination of microsomal xenobiotic N-demethylation in the presence of ascorbic acid Tris buffer and Nash reagent
Lech Zychlinski, Patricia Raska-Emery & Mark R. Montgomery
Pages: 485-490
Published online: 30 Sep 2009
AbstractforArtifacts in the determination of microsomal xenobiotic N-demethylation in the presence of ascorbic acid Tris buffer and Nash reagent | References | PDF (347.4 KB)
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Article
Microsomal metabolism and covalent binding of [3H/14C]-bromobenzene. Evidence for quinones as reactive metabolites
N. Narasimhan, Paul E. Weller, John A. Buben, Robert A. Wiley & Robert P. Hanzlik
Pages: 491-499
Published online: 30 Sep 2009
AbstractforMicrosomal metabolism and covalent binding of [3H/14C]-bromobenzene. Evidence for quinones as reactive metabolites | References | PDF (634.8 KB)
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Article
Effects of chemical and enzymic probes on microsomal covalent binding of bromobenzene and derivatives. Evidence for quinones as reactive metabolites
John A. Buben, N. Narasimhan & Robert P. Hanzlik
Pages: 501-510
Published online: 30 Sep 2009
AbstractforEffects of chemical and enzymic probes on microsomal covalent binding of bromobenzene and derivatives. Evidence for quinones as reactive metabolites | References | PDF (633.5 KB)
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Article
Sulphation and glucuronidation of xamoterol in the dog: Dose dependence and site of sulphation
Kees Groen, Alan Warrander, Glenys S. Miles, Bryan S. Booth & Gerard J. Mulder
Pages: 511-518
Published online: 30 Sep 2009
AbstractforSulphation and glucuronidation of xamoterol in the dog: Dose dependence and site of sulphation | References | PDF (462.5 KB)
  • 25 Views
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Article
The pharmacokinetics and metabolism of idazoxan in the rat
C. J. Lewis, M. E. Havler, M. J. Humphrey, J. G. Lloyd-Jones, M. A. McCleavy, N. C. Muir & K. Waltham
Pages: 519-532
Published online: 30 Sep 2009
AbstractforThe pharmacokinetics and metabolism of idazoxan in the rat | References | PDF (3.6 MB)
  • 80 Views
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Article
Metabolic chiral inversion of anti-inflammatory 2-arylpropionates: Lack of reaction in liver homogenates, and study of methine proton acidity
Joachim M. Mayer, Cecilia Bartolucci, Jean-Michel Maítre & Bernard Testa
Pages: 533-543
Published online: 30 Sep 2009
AbstractforMetabolic chiral inversion of anti-inflammatory 2-arylpropionates: Lack of reaction in liver homogenates, and study of methine proton acidity | References | PDF (668 KB)
  • 17 Views
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Article
Biophysical and catalytic properties of the phenobarbital p-hydroxylase—a cytochrome P-450 dependent mixed function oxidase
Wieslawa Maniara, Sidney S. Levin, Heinz Schleyer & David Y. Cooper
Pages: 545-550
Published online: 30 Sep 2009
AbstractforBiophysical and catalytic properties of the phenobarbital p-hydroxylase—a cytochrome P-450 dependent mixed function oxidase | References | PDF (444.3 KB)
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Article
Aminopyrine metabolism in primary monolayer cultures of diabetic rat hepatocytes
Hiroshi Shimeno, Akihisa Toda, Atsuo Nagamatsu & Hidenari Shigematsu
Pages: 551-560
Published online: 30 Sep 2009
AbstractforAminopyrine metabolism in primary monolayer cultures of diabetic rat hepatocytes | References | PDF (2.1 MB)
  • 6 Views
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Article
Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences
W. Krause & G. KÜhne
Pages: 561-571
Published online: 30 Sep 2009
AbstractforPharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences | References | PDF (498 KB)
  • 161 Views
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Article
Disposition of (—)-fenfluramine and its active metabolite, (—)-norfenfluramine in rat: A single dose-proportionality study
R. Spinelli, C. Fracasso, G. Guiso, S. Garattini & S. Caccia
Pages: 573-584
Published online: 30 Sep 2009
AbstractforDisposition of (—)-fenfluramine and its active metabolite, (—)-norfenfluramine in rat: A single dose-proportionality study | References | PDF (718.9 KB)
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Article
Enhanced faecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats by a long-term treatment with activated charcoal beads
H. Kamimura, N. Koga, K. Oguri, H. Yoshimura, Y. Honda & M. Nakano
Pages: 585-592
Published online: 30 Sep 2009
AbstractforEnhanced faecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats by a long-term treatment with activated charcoal beads | References | PDF (478.7 KB)
  • 7 Views
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Article
The influence of diaziquone free radicals on the in vitro activity of diaziquone
Binh Nguyen, Sandip Biswal & Peter L. Gutierrez
Pages: 593-602
Published online: 30 Sep 2009
AbstractforThe influence of diaziquone free radicals on the in vitro activity of diaziquone | References | PDF (533.9 KB)
  • 7 Views
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Article
Human dose-excretion studies with pyrethroid insecticides cypermethrin and alphacypermethrin: Relevance for biological monitoring
C. V. Eadsforth, P. C. Bragt & N. J. Van Sittert
Pages: 603-614
Published online: 30 Sep 2009
AbstractforHuman dose-excretion studies with pyrethroid insecticides cypermethrin and alphacypermethrin: Relevance for biological monitoring | References | PDF (739.1 KB)
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