Xenobiotica, Volume 22, Issue 7 (1992)

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Xenobiotica, Volume 22, Issue 7 (1992)

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Editorial

Editorial
The Drug Metabolism Discussion Group 1991
Richard A. Franklin, Colin W. Vose & Hugh Wiltshire
Pages: 733-734
Published online: 22 Sep 2008
CitationforThe Drug Metabolism Discussion Group 1991 | PDF (108.4 KB)
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Comment

Article Commentary
Twenty years on: a review of the current practice of drug metabolism and pharmacokinetic studies in the pharmaceutical industry
J. A. Bell & M. H. Tarbit
Pages: 735-742
Published online: 22 Sep 2008
AbstractforTwenty years on: a review of the current practice of drug metabolism and pharmacokinetic studies in the pharmaceutical industry | References | PDF (534.7 KB)
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Research Article

Article
Role of metabolism and pharmacokinetic studies in the discovery of new drugs—present and future perspectives
M. J. Humphrey & D. A. Smith
Pages: 743-755
Published online: 22 Sep 2008
AbstractforRole of metabolism and pharmacokinetic studies in the discovery of new drugs—present and future perspectives | References | PDF (818.9 KB)
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Article
Drug analysis of biological samples. A survey of validation approaches in chromatography in the UK pharmaceutical industry
P. Arnoux & R. Morrison
Pages: 757-764
Published online: 22 Sep 2008
AbstractforDrug analysis of biological samples. A survey of validation approaches in chromatography in the UK pharmaceutical industry | References | PDF (454.8 KB)
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Article
Direct injection/h.p.l.c. methods for the analysis of drugs in biological samples
E. Doyle, R. Huber & V. S. Picot
Pages: 765-774
Published online: 22 Sep 2008
AbstractforDirect injection/h.p.l.c. methods for the analysis of drugs in biological samples | References | PDF (607.2 KB)
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Article
Application of 19F.n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor
P. J. Gilbert, T. E. Hartley, J. A. Troke, R. G. Turcan, C. W. Vose & K. V. Watson
Pages: 775-787
Published online: 22 Sep 2008
AbstractforApplication of 19F.n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor | References | PDF (706 KB)
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Article
Advantages of achiral h.p.l.c. as a preparative step for chiral analysis in biological samples and its use in toxicokinetic studies
A. P. Beresford, K. Caswell, R. Chambers & I. P. Kirk
Pages: 789-798
Published online: 22 Sep 2008
AbstractforAdvantages of achiral h.p.l.c. as a preparative step for chiral analysis in biological samples and its use in toxicokinetic studies | References | PDF (585.5 KB)
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Article
Disposition of the enantiomers of cromakalim in rat and cynomolgus monkey
P. W. Tomlinson, J. V. Ramji & C. W. Filer
Pages: 799-814
Published online: 22 Sep 2008
AbstractforDisposition of the enantiomers of cromakalim in rat and cynomolgus monkey | References | PDF (825.8 KB)
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Article
Comparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes
K. Lavrijsen, J. Van Houdt, D. Van Dyck, J. Hendrickx, M. Bockx, R. Hurkmans, W. Meuldermans, L. Le Jeune, W. Lauwers & J. Heykants
Pages: 815-836
Published online: 22 Sep 2008
AbstractforComparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes | References | PDF (1.3 MB)
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Article
Metabolism of calcium antagonist Ro 40-5967: a case history of the use of diode-array u.v. spectroscopy and thermospray-mass spectrometry in the elucidation of a complex metabolic pathway
H. R. Wiltshire, S. R. Harris, K. J. Prior, U. M. Kozlowski & E. Worth
Pages: 837-857
Published online: 22 Sep 2008
AbstractforMetabolism of calcium antagonist Ro 40-5967: a case history of the use of diode-array u.v. spectroscopy and thermospray-mass spectrometry in the elucidation of a complex metabolic pathway | References | PDF (736.2 KB)
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Article
Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers
K. M. Hughes, J. C. T. Lang, R. Lazare, D. Gordon, S. L. Stanton, J. Malone-Lee & M. Geraint
Pages: 859-869
Published online: 22 Sep 2008
AbstractforMeasurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers | References | PDF (566.3 KB)
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Article
Value of early pharmacodynamic and pharmacokinetic investigations with anticancer drugs: data from phase I tolerance studies on a new vinca alkaloid derivative
R. M. J. Ings, E. Lelièvre, C. Ardiet, M. Clavel, S. Leyvraz, D. Minaidis, F. Lokiec, F. Turpin, P. Solere & C. Lucas
Pages: 871-880
Published online: 22 Sep 2008
AbstractforValue of early pharmacodynamic and pharmacokinetic investigations with anticancer drugs: data from phase I tolerance studies on a new vinca alkaloid derivative | References | PDF (548.4 KB)
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Review

Review Article
Statistical aspects of bioequivalence—a review
A. W. Pidgen
Pages: 881-893
Published online: 22 Sep 2008
AbstractforStatistical aspects of bioequivalence—a review | References | PDF (709.6 KB)
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Obituary

Obituary
Obituary
Robert Herman Nimmo-Smith
Pages: 895-896
Published online: 22 Sep 2008
CitationforObituary | PDF (86.5 KB)
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Obituary
Obituary
David Foulkes
Pages: 897-898
Published online: 22 Sep 2008
CitationforObituary | PDF (79.4 KB)
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