Xenobiotica, Volume 26, Issue 9 (1996)

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Xenobiotica, Volume 26, Issue 9 (1996)

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Original Article

Article
Interspecies scaling: predicting clearance of drugs in humans. Three different approaches
I. Mahmood & J. D. Balian
Pages: 887-895
Published online: 27 Aug 2009
AbstractforInterspecies scaling: predicting clearance of drugs in humans. Three different approaches | References | PDF (568.9 KB)
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Article
Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition
P. D. Worboys, B. Brennan, A. Bradbury & J. B. Houston
Pages: 897-907
Published online: 27 Aug 2009
AbstractforMetabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition | References | PDF (656.4 KB)
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Article
β-Apo-8′-carotenal, but not β-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat
S. Gradelet, J. Leclerc, M-H. Siess & P. O. Astorg
Pages: 909-919
Published online: 27 Aug 2009
Abstractforβ-Apo-8′-carotenal, but not β-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat | References | PDF (915.8 KB)
  • 56 Views
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Article
Metabolism of 14C-sulphadimethoxane in swine
P. E. Adams, V. J. Feil & G. D. Paulson
Pages: 921-933
Published online: 27 Aug 2009
AbstractforMetabolism of 14C-sulphadimethoxane in swine | References | PDF (772.9 KB)
  • 15 Views
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Article
The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations
SK. Bezek, M. Kukan, W. F. Pool & T. F. Woolf
Pages: 935-946
Published online: 27 Aug 2009
AbstractforThe effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations | References | PDF (795.2 KB)
  • 30 Views
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Article
Absorption and disposition of ranitidine hydrochloride in rat and dog
P. J. Eddershaw, A. P. Chadwick, D. M. Higton, S. H. Fenwick, P. Linacre, W. N. Jenner, J. A. Bell & G. R. Manchee
Pages: 947-956
Published online: 27 Aug 2009
AbstractforAbsorption and disposition of ranitidine hydrochloride in rat and dog | References | PDF (486.3 KB)
  • 114 Views
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Article
Discontinuous distribution of N-oxidation of dietary-derived trimethylamine in a British population
A. Q. Zhang, S. C. Mitchell & R. L. Smith
Pages: 957-961
Published online: 27 Aug 2009
AbstractforDiscontinuous distribution of N-oxidation of dietary-derived trimethylamine in a British population | References | PDF (300.2 KB)
  • 37 Views
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Article
Modipafant, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man
S. G. Jezequel, S. Uden & P. Wastall
Pages: 963-975
Published online: 27 Aug 2009
AbstractforModipafant, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man | References | PDF (1.2 MB)
  • 40 Views
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Article
Use of site-specified tritium labelling to confirm the formation of 17-oxosparteine as a minor urinary metabolite of sparteine in man
J. C. Ritchie, S. C. Mitchell, R. L. Smith & A. Q. Zhang
Pages: 977-982
Published online: 27 Aug 2009
AbstractforUse of site-specified tritium labelling to confirm the formation of 17-oxosparteine as a minor urinary metabolite of sparteine in man | References | PDF (377.2 KB)
  • 16 Views
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Article
Identification of major biliary and urinary metabolites of ecabapide in rats
M. Nakaoka, M. Tsumura, E. Ichikawa, W. Suzuki, H. Hakusui & T. Nakazawa
Pages: 983-994
Published online: 27 Aug 2009
AbstractforIdentification of major biliary and urinary metabolites of ecabapide in rats | References | PDF (586.3 KB)
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