Xenobiotica, Volume 34, Issue 5 (2004)

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Xenobiotica, Volume 34, Issue 5 (2004)

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Research Article

Article
Model for the drug–drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans
T. Kanazu, Y. Yamaguchi, N. Okamura, T. Baba & M. Koike
Pages: 391-402
Published online: 22 Sep 2008
AbstractforModel for the drug–drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans | References | PDF (236.5 KB)
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Article
Model for the drug–drug interaction responsible for CYP3A enzyme inhibition. II: establishment and evaluation of dexamethasone-pretreated female rats
T. Kanazu, Y. Yamaguchi, N. Okamura, T. Baba & M. Koike
Pages: 403-413
Published online: 22 Sep 2008
AbstractforModel for the drug–drug interaction responsible for CYP3A enzyme inhibition. II: establishment and evaluation of dexamethasone-pretreated female rats | References | PDF (200.2 KB)
  • 160 Views
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Article
Identification and relative contributions of human cytochrome P450 isoforms involved in the metabolism of glibenclamide and lansoprazole: evaluation of an approach based on the in vitro substrate disappearance rate
Y. Naritomi, S. Terashita & A. Kagayama
Pages: 415-427
Published online: 22 Sep 2008
AbstractforIdentification and relative contributions of human cytochrome P450 isoforms involved in the metabolism of glibenclamide and lansoprazole: evaluation of an approach based on the in vitro substrate disappearance rate | References | PDF (145.3 KB)
  • 275 Views
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Article
Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes
K. H. Liu, Y. M. Lee, J. H. Shon, M. J. Kim, S. S. Lee, Y. R. Yoon, I. J. Cha & J. G. Shin
Pages: 429-438
Published online: 22 Sep 2008
AbstractforPotential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes | References | PDF (127.6 KB)
  • 142 Views
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Article
Pharmacokinetic analysis of factors determining elimination pathways for sulfate and glucuronide metabolites of xenobiotics. iii: mechanisms for sinusoidal efflux of 4-methylumbelliferone sulfate
C. Nishida, K.-I. Ogawara, T. Kimura & K. Higaki
Pages: 439-448
Published online: 22 Sep 2008
AbstractforPharmacokinetic analysis of factors determining elimination pathways for sulfate and glucuronide metabolites of xenobiotics. iii: mechanisms for sinusoidal efflux of 4-methylumbelliferone sulfate | References | PDF (137.8 KB)
  • 38 Views
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Article
Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man
K. Tougou, H. Gotou, Y. Ohno & A. Nakamura
Pages: 449-461
Published online: 22 Sep 2008
AbstractforStereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man | References | PDF (152.5 KB)
  • 140 Views
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Article
Role of CYP3A enzymes in the biotransformation of triazolam in rat liver
J. S. Warrington, D. J. Greenblatt & L. L. Von Moltke
Pages: 463-471
Published online: 22 Sep 2008
AbstractforRole of CYP3A enzymes in the biotransformation of triazolam in rat liver | References | PDF (120.9 KB)
  • 79 Views
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Article
Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4
Z. Zhang, Y. Li, M. Shou, Y. Zhang, J. S. Ngui, R. A. Stearns, D. C. Evans, T. A. Baillie & W. Tang
Pages: 473-486
Published online: 22 Sep 2008
AbstractforInfluence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4 | References | PDF (284.4 KB)
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Article
Disposition and pharmacokinetics of temozolomide in rat
L. Reyderman, P. Statkevich, C. M. Thonoor, J. Patrick, V. K. Batra & M. Wirth
Pages: 487-500
Published online: 22 Sep 2008
AbstractforDisposition and pharmacokinetics of temozolomide in rat | References | PDF (242.4 KB)
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