Xenobiotica, Volume 38, Issue 2 (2008)

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Xenobiotica, Volume 38, Issue 2 (2008)

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Research Article

Article
Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models
Y. Fan & R. Rodriguez-Proteau
Pages: 107-129
Published online: 22 Sep 2008
AbstractforKetoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models | Full Text | References | PDF (416.2 KB)
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Article
Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (–)-epigallocatechin-3-O-gallate
B. T. Zhu, J.-Y. Shim, M. Nagai & H.-W. Bai
Pages: 130-146
Published online: 22 Sep 2008
AbstractforMolecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (–)-epigallocatechin-3-O-gallate | Full Text | References | PDF (1.3 MB)
  • 168 Views
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Article
Effects of dietary salt on the expression of drug transporters, cytochrome P4503a, and nuclear receptors in rats
H. J. Kang, I. S. Song, S. S. Lee, M. A. Yoo & J. G. Shin
Pages: 147-155
Published online: 22 Sep 2008
AbstractforEffects of dietary salt on the expression of drug transporters, cytochrome P4503a, and nuclear receptors in rats | Full Text | References | PDF (192.8 KB)
  • 137 Views
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Article
Metabolism of OR-1896, a metabolite of levosimendan, in rats and humans
M. Koskinen, J. Puttonen, M. Pykäläinen, A. Vuorela & T. Lotta
Pages: 156-170
Published online: 22 Sep 2008
AbstractforMetabolism of OR-1896, a metabolite of levosimendan, in rats and humans | Full Text | References | PDF (368 KB)
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Article
Metabolism and disposition of [14C]5-amino-o-cresol in female F344 rats and B6C3F1 mice
B. Hedtke, Z. Gao, L.-J. Chen, W. M. Weber & K. J. Dix
Pages: 171-184
Published online: 22 Sep 2008
AbstractforMetabolism and disposition of [14C]5-amino-o-cresol in female F344 rats and B6C3F1 mice | Full Text | References | PDF (186.5 KB)
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Article
Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases
H.-C. Bi, Z. Zuo, X. Chen, C.-S. Xu, Y.-Y. Wen, H.-Y. Sun, L.-Z. Zhao, Y. Pan, Y. Deng, P.-Q. Liu, L.-Q. Gu, Z.-Y. Huang, S.-F. Zhou & M. Huang
Pages: 185-222
Published online: 22 Sep 2008
AbstractforPreclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases | Full Text | References | PDF (1.1 MB)
  • 282 Views
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Article
Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats
W. Tang, R. A. Stearns, Q. Chen, K. Bleasby, Y. Teffera, A. Colletti, M. Hafey, R. Evers, D. C. Dean, P. A. Magriotis, T. J. Lanza, L. S. Lin, W. K. Hagmann & T. A. Baillie
Pages: 223-237
Published online: 22 Sep 2008
AbstractforImportance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats | Full Text | References | PDF (149.7 KB)
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