Xenobiotica, Volume 39, Issue 1 (2009)

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Xenobiotica, Volume 39, Issue 1 (2009)

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Research Article

Article
Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone
H. H. Yoo, N. S. Kim, J. Lee, D. R. Sohn, C. Jin & D. H. Kim
Pages: 1-10
Published online: 29 Jan 2009
AbstractforCharacterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone | Full Text | References | PDF (984.2 KB)
  • 281 Views
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Article
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
J. E. Laine, S. Auriola, M. Pasanen & R. O. Juvonen
Pages: 11-21
Published online: 29 Jan 2009
AbstractforAcetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes | Full Text | References | PDF (860 KB)
  • 2641 Views
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Article
Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains
A. Bruyère, X. Declèves, F. Bouzom, L. Proust, M. Martinet, B. Walther & Y. Parmentier
Pages: 22-32
Published online: 29 Jan 2009
AbstractforDevelopment of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains | Full Text | References | PDF (1.1 MB)
  • 669 Views
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Article
Preclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences
S. Roller, D. Cui, C. Laspina, C. Miller-Stein, J. Rowe, B. Wong & T. Prueksaritanont
Pages: 33-45
Published online: 29 Jan 2009
AbstractforPreclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences | Full Text | References | PDF (1.1 MB)
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Article
Absorption, distribution, metabolism and excretion (ADME) study with 2,2′,4,4′,5,6′-hexabromodiphenyl ether (BDE-154) in male Sprague–Dawley rats
H. Hakk, J. K. Huwe & G. L. Larsen
Pages: 46-56
Published online: 29 Jan 2009
AbstractforAbsorption, distribution, metabolism and excretion (ADME) study with 2,2′,4,4′,5,6′-hexabromodiphenyl ether (BDE-154) in male Sprague–Dawley rats | Full Text | References | PDF (767.3 KB)
  • 323 Views
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Article
Presentation of a modified dispersion model (MDM) for hepatic drug extraction and a new methodology for the prediction of the rate-limiting step in hepatic metabolic clearance
U. Fagerholm
Pages: 57-71
Published online: 29 Jan 2009
AbstractforPresentation of a modified dispersion model (MDM) for hepatic drug extraction and a new methodology for the prediction of the rate-limiting step in hepatic metabolic clearance | Full Text | References | PDF (1 MB)
  • 110 Views
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Article
Trans-resveratrol-mediated inhibition of β-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes
D. Ung & S. Nagar
Pages: 72-79
Published online: 29 Jan 2009
AbstractforTrans-resveratrol-mediated inhibition of β-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes | Full Text | References | PDF (679.6 KB)
  • 158 Views
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Article
Mechanisms of action of two different natural mixtures of persistent organic pollutants (POPs) in ovarian follicles
E. L. Gregoraszczuk, A. Ptak, J. U. Skaare, K. Mularz, A. Chmielowiec, A. Wojtowicz & E. Ropstad
Pages: 80-89
Published online: 29 Jan 2009
AbstractforMechanisms of action of two different natural mixtures of persistent organic pollutants (POPs) in ovarian follicles | Full Text | References | PDF (710 KB)
  • 174 Views
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Article
Statin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy
J. Sidaway, Y. Wang, A. M. Marsden, T. C. Orton, F. R. Westwood, C. T. Azuma & R. C. Scott
Pages: 90-98
Published online: 29 Jan 2009
AbstractforStatin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy | Full Text | References | PDF (692.4 KB)
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