Xenobiotica, Volume 39, Issue 6 (2009)

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Xenobiotica, Volume 39, Issue 6 (2009)

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Research Article

Article
Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development
K. Mori, H. Hashimoto, H. Takatsu, M. Tsuda-Tsukimoto & T. Kume
Pages: 415-422
Published online: 01 Jun 2009
AbstractforCocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development | Full Text | References | PDF (728.2 KB)
  • 544 Views
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Article
Tissue distribution of CYP3A29 mRNA expression in Bama miniature pig by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)
H. Shang, J. Yang, Y. Liu & H. Wei
Pages: 423-429
Published online: 20 Mar 2009
AbstractforTissue distribution of CYP3A29 mRNA expression in Bama miniature pig by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) | Full Text | References | PDF (1.2 MB)
  • 143 Views
  • 22 CrossRef citations
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Article
Method for predicting the risk of drug–drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein
T. Tachibana, M. Kato, T. Watanabe, T. Mitsui & Y. Sugiyama
Pages: 430-443
Published online: 01 Jun 2009
AbstractforMethod for predicting the risk of drug–drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein | Full Text | References | PDF (1.2 MB)
  • 1252 Views
  • 60 CrossRef citations
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Article
In vitro metabolism of the specific endothelin-A receptor antagonist ZD4054 and clinical drug interactions between ZD4054 and rifampicin or itraconazole in healthy male volunteers
H. C. Swaisland, S. D. Oliver, T. Morris, H. K. Jones, A. Bakhtyari, A. Mackey, A. D. McCormick, D. Slamon, J. A. Hargreaves, A. Millar & M. T. Taboada
Pages: 444-456
Published online: 12 Mar 2009
AbstractforIn vitro metabolism of the specific endothelin-A receptor antagonist ZD4054 and clinical drug interactions between ZD4054 and rifampicin or itraconazole in healthy male volunteers | Full Text | References | PDF (1.5 MB)
  • 235 Views
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Article
Pharmacokinetics of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol and its active metabolite after oral and intravenous administration in rat
X. Zhang, J. Xu, D. Zhang, J. Gu & Y. Zhao
Pages: 457-464
Published online: 12 Mar 2009
AbstractforPharmacokinetics of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol and its active metabolite after oral and intravenous administration in rat | Full Text | References | PDF (999 KB)
  • 127 Views
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Article
Pharmacokinetics and first-pass effects of liquiritigenin in rats: low bioavailability is primarily due to extensive gastrointestinal first-pass effect
H. E. Kang, Y. K. Cho, H. Y. Jung, K. Y. Choi, S. I. Sohn, S. R. Baek & M. G. Lee
Pages: 465-475
Published online: 01 Jun 2009
AbstractforPharmacokinetics and first-pass effects of liquiritigenin in rats: low bioavailability is primarily due to extensive gastrointestinal first-pass effect | Full Text | References | PDF (1.3 MB)
  • 204 Views
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Article
Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes
M. Karaźniewicz-łada, M. łuczak & F. Główka
Pages: 476-485
Published online: 01 Jun 2009
AbstractforPharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes | Full Text | References | PDF (1.1 MB)
  • 396 Views
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