Xenobiotica, Volume 40, Issue 10 (2010)

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Xenobiotica, Volume 40, Issue 10 (2010)

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General Xenobiochemistry

Article
Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity
Mohamed-Eslam F. Mohamed, Tiffany Tseng & Reginald F. Frye
Pages: 663-669
Published online: 28 Jul 2010
AbstractforInhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity | Full Text | References | PDF (697.3 KB)
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Article
Constitutive expression of drug metabolizing enzymes and related transcription factors in cattle testis and their modulation by illicit steroids
Rosa Maria Lopparelli, Vanessa Zancanella, Mery Giantin, Licia Ravarotto, Giulio Cozzi, Clara Montesissa & Mauro Dacasto
Pages: 670-680
Published online: 28 Jul 2010
AbstractforConstitutive expression of drug metabolizing enzymes and related transcription factors in cattle testis and their modulation by illicit steroids | Full Text | References | PDF (796.9 KB)
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Article
The effectiveness of oracin in enhancing the cytotoxicity of doxorubicin through the inhibition of doxorubicin deactivation in breast cancer MCF7 cells
V. Hanušová, V. Králová, L. Schröterová, L. Trilecová, A. Pakostová & L. Skálová
Pages: 681-690
Published online: 10 Aug 2010
AbstractforThe effectiveness of oracin in enhancing the cytotoxicity of doxorubicin through the inhibition of doxorubicin deactivation in breast cancer MCF7 cells | Full Text | References | PDF (953.1 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans
Bindhu Karanam, Carol Addy, Thomas Bateman, Vijay Bhasker Reddy, Susie Li, Dennis Dean, Hankun Li, Allen Jones, David Schenk, Andy Shiqiang Zhang, Matt Braun, Amanda Freeman, Stephen Flach, Aubrey Stoch, Jeff Chodakewitz, John A. Wagner & Sanjeev Kumar
Pages: 691-700
Published online: 19 Aug 2010
AbstractforMetabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans | Full Text | References | PDF (737.9 KB)
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Article
Pharmacokinetic variability of voriconazole and N-oxide voriconazole measured as therapeutic drug monitoring
Céline Eiden, Marylène Cociglio, Dominique Hillaire-Buys, Sabrina Eymard-Duvernay, Patrice Ceballos, Nathalie Fegueux & Hélène Peyrière
Pages: 701-706
Published online: 19 Jul 2010
AbstractforPharmacokinetic variability of voriconazole and N-oxide voriconazole measured as therapeutic drug monitoring | Full Text | References | PDF (632.2 KB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics of lipoyl vildagliptin, a novel dipeptidyl peptidase IV inhibitor after oral administration in rats
X. Wang, D. Zhang, W. Xu, H. Liu & W. Wang
Pages: 707-712
Published online: 24 Aug 2010
AbstractforPharmacokinetics of lipoyl vildagliptin, a novel dipeptidyl peptidase IV inhibitor after oral administration in rats | Full Text | References | PDF (760.8 KB)
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Topics in Xenobiochemistry

Review Article
Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro
David J. Greenblatt, Karthik Venkatakrishnan, Jerold S. Harmatz, Sarah J. Parent & Lisa L. von Moltke
Pages: 713-720
Published online: 16 Aug 2010
AbstractforSources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro | Full Text | References | PDF (729.2 KB)
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