Xenobiotica, Volume 41, Issue 2 (2011)

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Xenobiotica, Volume 41, Issue 2 (2011)

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General Xenobiochemistry

Article
Presence and ex vivo formation of acridone in blood of patients routinely treated with carbamazepine: exploration of the 9-acridinecarboxaldehyde pathway
Olivier Mathieu, Olivier Dereure & Dominique Hillaire-Buys
Pages: 91-100
Published online: 18 Nov 2010
AbstractforPresence and ex vivo formation of acridone in blood of patients routinely treated with carbamazepine: exploration of the 9-acridinecarboxaldehyde pathway | Full Text | References | PDF (1.1 MB)
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Article
Metabolism of α-thujone in human hepatic preparations in vitro
Khaled Abass, Petri Reponen, Sampo Mattila & Olavi Pelkonen
Pages: 101-111
Published online: 18 Nov 2010
AbstractforMetabolism of α-thujone in human hepatic preparations in vitro | Full Text | References | PDF (883.9 KB)
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Article
Pregnane X receptor-mediated induction of Cyp3a by black cohosh
Xiaoyan Pang, Jie Cheng, Kristopher W. Krausz, De-an Guo & Frank J. Gonzalez
Pages: 112-123
Published online: 27 Oct 2010
AbstractforPregnane X receptor-mediated induction of Cyp3a by black cohosh | Full Text | References | PDF (1 MB) | Supplemental
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Article
Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance
Joanne A. Foster, J. Brian Houston & David Hallifax
Pages: 124-136
Published online: 09 Nov 2010
AbstractforComparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance | Full Text | References | PDF (749.7 KB)
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Animal Pharmacokinetics and Metabolism

Article
The effect of increased lipoprotein levels on the pharmacokinetics of ketoconazole enantiomers in the rat
Dalia A. Hamdy & Dion R. Brocks
Pages: 137-143
Published online: 09 Nov 2010
AbstractforThe effect of increased lipoprotein levels on the pharmacokinetics of ketoconazole enantiomers in the rat | Full Text | References | PDF (696.1 KB)
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Article
Urinary metabolites of 2-bromoethanamine identified by stable isotope labelling: evidence for carbamoylation and glutathione conjugation
Petia Shipkova, Jeffrey D. Vassallo, Nelly Aranibar, Serhiy Hnatyshyn, Haiying Zhang, T. Andrew Clayton, Glenn H. Cantor, Mark Sanders, Muireann Coen, John C. Lindon, Elaine Holmes, Jeremy K. Nicholson & Lois Lehman-McKeeman
Pages: 144-154
Published online: 02 Nov 2010
AbstractforUrinary metabolites of 2-bromoethanamine identified by stable isotope labelling: evidence for carbamoylation and glutathione conjugation | Full Text | References | PDF (1 MB) | Supplemental
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Article
Evaluation of the pharmacokinetics and metabolism of a novel histone deacetylase inhibitor, KBH-A40, in rats
S. J. Oh, K. Lee, J. Ryu, H. E. Yu, G. Han, S. K. Park, J. S. Kang, H. M. Kim & Y. C. Kim
Pages: 155-163
Published online: 11 Nov 2010
AbstractforEvaluation of the pharmacokinetics and metabolism of a novel histone deacetylase inhibitor, KBH-A40, in rats | Full Text | References | PDF (763 KB)
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Article
Pharmacokinetics of sildenafil and its metabolite, N-desmethylsildenafil, in rats with liver cirrhosis and diabetes mellitus, alone and in combination
C.Y. Ahn, S.K. Bae, S.H. Bae, H.E. Kang, S.H. Kim, M.G. Lee & W.G. Shin
Pages: 164-174
Published online: 11 Nov 2010
AbstractforPharmacokinetics of sildenafil and its metabolite, N-desmethylsildenafil, in rats with liver cirrhosis and diabetes mellitus, alone and in combination | Full Text | References | PDF (737.1 KB)
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