Xenobiotica, Volume 41, Issue 5 (2011)

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Xenobiotica, Volume 41, Issue 5 (2011)

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General Xenobiochemistry

Article
C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2
Ao-Xue Wang, Ying Hu, Hui-Xin Liu, Xiao-Yi Qi, Yong Liu, Cai-Xia Tu & Ling Yang
Pages: 349-357
Published online: 06 Jan 2011
AbstractforC5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2 | Full Text | References | PDF (799.7 KB)
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Clinical Pharmacokinetics and Metabolism

Article
In vitro metabolism of magnolin and characterization of cytochrome P450 enzymes responsible for its metabolism in human liver microsomes
Dong Kyun Kim, Kwang-Hyeon Liu, Ji Hyun Jeong, Hye Young Ji, Sei-Ryang Oh, Hyeong-Kyu Lee & Hye Suk Lee
Pages: 358-371
Published online: 04 Feb 2011
AbstractforIn vitro metabolism of magnolin and characterization of cytochrome P450 enzymes responsible for its metabolism in human liver microsomes | Full Text | References | PDF (1.1 MB)
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Article
Case report of extensive metabolism by aldehyde oxidase in humans: Pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans
Takafumi Akabane, Kohichiro Tanaka, Megumi Irie, Shigeyuki Terashita & Toshio Teramura
Pages: 372-384
Published online: 09 Mar 2011
AbstractforCase report of extensive metabolism by aldehyde oxidase in humans: Pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans | Full Text | References | PDF (961.3 KB)
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Animal Pharmacokinetics and Metabolism

Article
Absorption, excretion, and metabolism of a potential GABA-Aα2/3 receptor modulator in rats
Jian Guo, Patty C. Davis, Chungang Gu & Scott W. Grimm
Pages: 385-399
Published online: 06 Jan 2011
AbstractforAbsorption, excretion, and metabolism of a potential GABA-Aα2/3 receptor modulator in rats | Full Text | References | PDF (1.1 MB)
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Article
In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases
Liyue Huang, Xuhai Be, Loren Berry, Earl Moore, Brett Janosky, Mary Wells, Wei-Jian Pan, Zhiyang Zhao & Min-Hwa Jasmine Lin
Pages: 400-408
Published online: 04 Feb 2011
AbstractforIn vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases | Full Text | References | PDF (709 KB)
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Article
Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine
Y. H. Choi, U. Lee, J. H. Suh, Y. G. Kim, M. Lee, E. Oh & M. G. Lee
Pages: 409-415
Published online: 21 Jan 2011
AbstractforPharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine | Full Text | References | PDF (679.4 KB)
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Article
Effect of pregnancy on topiramate pharmacokinetics in rabbits
Kamal M. Matar & Najlaa A. Marafie
Pages: 416-421
Published online: 27 Jan 2011
AbstractforEffect of pregnancy on topiramate pharmacokinetics in rabbits | Full Text | References | PDF (630.4 KB)
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Article
Organophosphorus pesticide degradation product in vitro metabolic stability and time-course uptake and elimination in rats following oral and intravenous dosing
N. D. Forsberg, R. Rodriguez-Proteau, L. Ma, J. Morré, J. M. Christensen, C. S. Maier, J. J. Jenkins & K. A. Anderson
Pages: 422-429
Published online: 29 Mar 2011
AbstractforOrganophosphorus pesticide degradation product in vitro metabolic stability and time-course uptake and elimination in rats following oral and intravenous dosing | Full Text | References | PDF (719.6 KB)
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Article
Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey
Olaf Kuhlmann & Katja Heinig
Pages: 430-436
Published online: 24 Feb 2011
AbstractforDalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey | Full Text | References | PDF (716.4 KB)
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