Xenobiotica, Volume 42, Issue 12 (2012)

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Xenobiotica, Volume 42, Issue 12 (2012)

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General Xenobiochemistry

Article
Mechanism-based inhibition of human Cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content
David J. Greenblatt, Yanli Zhao, Michael J. Hanley, Chunxian Chen, Jerold S. Harmatz, Paul F. Cancalon & Frederick G. Gmitter Jr.
Pages: 1163-1169
Published online: 18 Jul 2012
AbstractforMechanism-based inhibition of human Cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content | Full Text | References | PDF (781.9 KB)
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Article
Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite
Cody J. Peer, Islam R. Younis, Stephen S. Leonard, Peter M. Gannett, Valerie C. Minarchick, Allison J. Kenyon, Yon Rojanasakul & Patrick S. Callery
Pages: 1170-1177
Published online: 22 Jun 2012
AbstractforGlutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite | Full Text | References | PDF (748.3 KB)
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Article
Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase
James C. H. Poon & P. David Josephy
Pages: 1178-1186
Published online: 29 Jun 2012
AbstractforHydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase | Full Text | References | PDF (739.1 KB)
  • 169 Views
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Article
In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist
Shin Takusagawa, Aiji Miyashita, Takafumi Iwatsubo & Takashi Usui
Pages: 1187-1196
Published online: 27 Jul 2012
AbstractforIn vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist | Full Text | References | PDF (798.4 KB)
  • 739 Views
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Article
The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP
Siyuan Sun, Zhongjian Chen, Liping Li, Dongli Sun, Ye Tian, Hao Pan, Huichang Bi, Min Huang, Su Zeng & Huidi Jiang
Pages: 1197-1205
Published online: 19 Aug 2012
AbstractforThe two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP | Full Text | References | PDF (748.8 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Isolation and identification of the metabolites of paeonol in human urine
Liqin Ding, Zhaoxi Liu, Feng Zhao, Gang Bai, Lixia Chen, Xinsheng Yao & Feng Qiu
Pages: 1206-1212
Published online: 09 Jun 2012
AbstractforIsolation and identification of the metabolites of paeonol in human urine | Full Text | References | PDF (827.8 KB)
  • 300 Views
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Animal Pharmacokinetics and Metabolism

Article
Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice
James M. Mathews, Qiao Zhan, Amy S. Etheridge, Purvi R. Patel, Sherry R. Black, Troy T. Banks, Timothy R. Fennell, Rodney W. Snyder, Jason P. Burgess, Stephen D. Warren, Inok Surh & Suramya Waidyanatha
Pages: 1213-1224
Published online: 23 Jun 2012
AbstractforMetabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice | Full Text | References | PDF (924.5 KB)
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Article
Effects of cysteine on the pharmacokinetics of tamoxifen in rats with protein-calorie malnutrition
Yu Kyung Lee, Insoo Yoon, Myung Gull Lee & Young Hee Choi
Pages: 1225-1234
Published online: 04 Oct 2012
AbstractforEffects of cysteine on the pharmacokinetics of tamoxifen in rats with protein-calorie malnutrition | Full Text | References | PDF (721.8 KB)
  • 170 Views
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Molecular Toxicology

Article
Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart
Anwar Anwar-Mohamed, Ahmed A. El-Sherbeni, Seok H. Kim, Hassan N. Althurwi, Beshay N. M. Zordoky & Ayman O. S. El-Kadi
Pages: 1235-1247
Published online: 09 Jun 2012
AbstractforAcute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart | Full Text | References | PDF (985.5 KB)
  • 489 Views
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Pharmacogenetics

Article
Effects of curcumin on the pharmacokinetics of talinolol in human with ABCB1 polymorphism
X. He, L. Mo, Z.-Y. Li, Z.-R. Tan, Y. Chen & D.-S. Ouyang
Pages: 1248-1254
Published online: 22 Jun 2012
AbstractforEffects of curcumin on the pharmacokinetics of talinolol in human with ABCB1 polymorphism | Full Text | References | PDF (859.7 KB)
  • 405 Views
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Article
Bioactivation of chlorpyrifos by CYP2B6 variants
Alice L. Crane, Kathrin Klein & James R. Olson
Pages: 1255-1262
Published online: 10 Jul 2012
AbstractforBioactivation of chlorpyrifos by CYP2B6 variants | Full Text | References | PDF (695.2 KB)
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Acknowledgements

Acknowledgements
Pages: 1263-1264
Published online: 07 Nov 2012
CitationforAcknowledgements | Full Text | PDF (505.5 KB)
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