Xenobiotica, Volume 42, Issue 1 (2012)

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Xenobiotica, Volume 42, Issue 1 (2012)

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Preface

Personal reflections of Pfizer Sandwich Laboratories
Simon Campbell FMedSci, FRS
Page: 1
Published online: 05 Dec 2011
CitationforPersonal reflections of Pfizer Sandwich Laboratories | Full Text | PDF (492.3 KB)
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Pfizer Sandwich Laboratories: where drug metabolism first met drug discovery
Dennis Smith
Pages: 2-3
Published online: 05 Dec 2011
CitationforPfizer Sandwich Laboratories: where drug metabolism first met drug discovery | Full Text | References | PDF (510.2 KB)
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Review Article

Review Article
Are predictive biomarkers of toxicity worth having? An economic model
Byron Jones, Dennis A. Smith & Esther F. Schmid
Pages: 4-10
Published online: 04 Oct 2011
AbstractforAre predictive biomarkers of toxicity worth having? An economic model | Full Text | References | PDF (579.8 KB)
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Review Article
Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration
Susan Cole, Sharan Bagal, Ayman El-Kattan, Katherine Fenner, Tanya Hay, Sarah Kempshall, Graham Lunn, Manthena Varma, Paul Stupple & William Speed
Pages: 11-27
Published online: 04 Oct 2011
AbstractforFull efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration | Full Text | References | PDF (1,003.4 KB)
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Review Article
The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance
Katherine S. Fenner, Hannah M. Jones, Mohammed Ullah, Sarah Kempshall, Maurice Dickins, Yurong Lai, Paul Morgan & Hugh A. Barton
Pages: 28-45
Published online: 11 Nov 2011
AbstractforThe evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance | Full Text | References | PDF (769.1 KB)
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Review Article
Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?
R. Scott Obach, Angus N. Nedderman & Dennis A. Smith
Pages: 46-56
Published online: 12 Oct 2011
AbstractforRadiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary? | Full Text | References | PDF (1.4 MB)
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Review Article
Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms
Anthony Harrison, Iain Gardner, Tanya Hay, Maurice Dickins, Kevin Beaumont, Alex Phipps, Lynn Purkins, Gill Allan, Rachelle Christian, Jonathan Duckworth, Ian Gurrell, Sarah Kempshall, Mark Savage, Mark Seymour, Marie Simpson, Louise Taylor & Paul Turnpenny
Pages: 57-74
Published online: 12 Oct 2011
AbstractforCase studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms | Full Text | References | PDF (945.8 KB)
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Review Article
A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats
Rhys M. Jones & Anthony Harrison
Pages: 75-85
Published online: 11 Nov 2011
AbstractforA new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats | Full Text | References | PDF (764.4 KB)
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Review Article
Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity
Rhys M. Jones & Natasha Neef
Pages: 86-93
Published online: 22 Nov 2011
AbstractforInterpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity | Full Text | References | PDF (719.8 KB)
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Review Article
Application of PBPK modelling in drug discovery and development at Pfizer
Hannah M Jones, Maurice Dickins, Kuresh Youdim, James R Gosset, Neil J Attkins, Tanya L Hay, Ian K Gurrell, Y Raj Logan, Peter J Bungay, Barry C Jones & Iain B Gardner
Pages: 94-106
Published online: 30 Oct 2011
AbstractforApplication of PBPK modelling in drug discovery and development at Pfizer | Full Text | References | PDF (820.2 KB)
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Review Article
Why do metabolites circulate?
Dennis A. Smith & Deepak Dalvie
Pages: 107-126
Published online: 24 Nov 2011
AbstractforWhy do metabolites circulate? | Full Text | References | PDF (2.1 MB)
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