Xenobiotica, Volume 42, Issue 6 (2012)

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Xenobiotica, Volume 42, Issue 6 (2012)

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General Xenobiochemistry

Article
Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers
Timothy Schulz-Utermoehl, Sunil Sarda, John R. Foster, Matt Jacobsen, J. Gerry Kenna, Yoshio Morikawa, Juuso Salmu, Gerhard Gross & Ian D. Wilson
Pages: 503-517
Published online: 27 Dec 2011
AbstractforEvaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers | Full Text | References | PDF (986.6 KB)
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Article
Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine
Ling Ye, Song Gao, Qian Feng, Wei Liu, Zhen Yang, Ming Hu & Zhongqiu Liu
Pages: 518-525
Published online: 22 Dec 2011
AbstractforDevelopment and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine | Full Text | References | PDF (1.2 MB)
  • 305 Views
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Article
Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models
Christine Götz, Nicola J. Hewitt, Erich Jermann, Julia Tigges, Zippora Kohne, Ulrike Hübenthal, Jean Krutmann, Hans F Merk & Ellen Fritsche
Pages: 526-537
Published online: 17 Dec 2011
AbstractforEffects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models | Full Text | References | PDF (933 KB)
  • 173 Views
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Article
The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers
Andrew Crowe & Cameron Wright
Pages: 538-549
Published online: 22 Dec 2011
AbstractforThe impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers | Full Text | References | PDF (717.3 KB)
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Article
Carbonyl reduction of bupropion in human liver
Jillissa C. Molnari & Alan L. Myers
Pages: 550-561
Published online: 20 Feb 2012
AbstractforCarbonyl reduction of bupropion in human liver | Full Text | References | PDF (981.1 KB)
  • 462 Views
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Article
Reversal of P-glycoprotein-mediated multidrug resistance in human hepatoma cells by hedyotiscone A, a compound isolated from Hedyotis corymbosa
Grace Gar-Lee Yue, Julia Kin-Ming Lee, Ling Cheng, Ben Chung-Lap Chan, Lei Jiang, Kwok-Pui Fung, Ping-Chung Leung & Clara Bik-San Lau
Pages: 562-570
Published online: 21 Feb 2012
AbstractforReversal of P-glycoprotein-mediated multidrug resistance in human hepatoma cells by hedyotiscone A, a compound isolated from Hedyotis corymbosa | Full Text | References | PDF (1.2 MB)
  • 198 Views
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Article
The influence of oracin on reduction and toxicity of doxorubicin in hepatocytes and mammary epithelial cells MCF-10A
V. Hanušová, I. Boušová, A. Pakostová & L. Skálová
Pages: 571-579
Published online: 04 Jan 2012
AbstractforThe influence of oracin on reduction and toxicity of doxorubicin in hepatocytes and mammary epithelial cells MCF-10A | Full Text | References | PDF (1 MB)
  • 174 Views
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Article
Stereoselective degradation of metalaxyl and its enantiomers in rat and rabbit hepatic microsomes in vitro
Ping Zhang, Zhigang Shen, Xinyuan Xu, Wentao Zhu, Ziheng Dang, Xinru Wang, Donghui Liu & Zhiqiang Zhou
Pages: 580-586
Published online: 20 Feb 2012
AbstractforStereoselective degradation of metalaxyl and its enantiomers in rat and rabbit hepatic microsomes in vitro | Full Text | References | PDF (690.4 KB)
  • 145 Views
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Article
The effects of a high-fat and high-energy diet on the hepatic expression of CYP3A in developing female rats
Shaoqing Ni, Xiumin Wang, Jue Wang, Zhengyan Zhao & Su Zeng
Pages: 587-595
Published online: 11 Jan 2012
AbstractforThe effects of a high-fat and high-energy diet on the hepatic expression of CYP3A in developing female rats | Full Text | References | PDF (1.2 MB)
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Article
Effect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers
Y. Chen, D.-S. Ouyang, Z. Kang, G.-P. Yang, Z.-R. Tan, G. Zhou & J. Yan
Pages: 596-602
Published online: 30 Dec 2011
AbstractforEffect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers | Full Text | References | PDF (859.4 KB)
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