Xenobiotica, Volume 42, Issue 9 (2012)

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Xenobiotica, Volume 42, Issue 9 (2012)

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General Xenobiochemistry

Article
Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities
Yuichiro Sato, Masanori Nagata, Akio Kawamura, Aiji Miyashita & Takashi Usui
Pages: 823-829
Published online: 21 Mar 2012
AbstractforProtein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities | Full Text | References | PDF (887.8 KB)
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Article
Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds
Liyue Huang, April Chen, John Roberts, Brett Janosky, Xuhai Be, Loren Berry & Min-Hwa Jasmine Lin
Pages: 830-840
Published online: 22 Mar 2012
AbstractforUse of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds | Full Text | References | PDF (727.2 KB)
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Article
Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes
Anna-Karin Sohlenius-Sternbeck, Christopher Jones, Douglas Ferguson, Brian J. Middleton, Denis Projean, Eva Floby, Johan Bylund & Lovisa Afzelius
Pages: 841-853
Published online: 18 Apr 2012
AbstractforPractical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes | Full Text | References | PDF (1.1 MB)
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Article
Effects of silver nanoparticles on rat hepatic cytochrome P450 enzyme activity
Kornphimol Kulthong, Rawiwan Maniratanachote, Yuki Kobayashi, Tatsuki Fukami & Tsuyoshi Yokoi
Pages: 854-862
Published online: 30 Mar 2012
AbstractforEffects of silver nanoparticles on rat hepatic cytochrome P450 enzyme activity | Full Text | References | PDF (913.1 KB)
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Article
A quantitative approach to hepatic clearance prediction of metabolism by aldehyde oxidase using custom pooled hepatocytes
Takafumi Akabane, Nicolas Gerst, Jeffrey N. Masters & Kouichi Tamura
Pages: 863-871
Published online: 26 Mar 2012
AbstractforA quantitative approach to hepatic clearance prediction of metabolism by aldehyde oxidase using custom pooled hepatocytes | Full Text | References | PDF (915.1 KB)
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Article
Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase
Iva Boušová, Jan Hájek, Jaroslav Dršata & Lenka Skálová
Pages: 872-879
Published online: 30 Mar 2012
AbstractforNaturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase | Full Text | References | PDF (857 KB)
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Article
Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier
Ziqiang Cheng, Houfu Liu, Na Yu, Fei Wang, Gang An, Yan Xu, Qian Liu, Chen-bing Guan & Andrew Ayrton
Pages: 880-890
Published online: 18 Apr 2012
AbstractforHydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier | Full Text | References | PDF (1.9 MB)
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Article
3D-QSAR studies on UDP-glucuronosyltransferase 2B7 substrates using the pharmacophore and VolSurf approaches
Roland Ako, Dong Dong & Baojian Wu
Pages: 891-900
Published online: 12 Apr 2012
Abstractfor3D-QSAR studies on UDP-glucuronosyltransferase 2B7 substrates using the pharmacophore and VolSurf approaches | Full Text | References | PDF (1.2 MB) | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans
Shirin Bruderer, Gérard Hopfgartner, Michael Seiberling, Janine Wank, Patricia N. Sidharta, Alexander Treiber & Jasper Dingemanse
Pages: 901-910
Published online: 30 Mar 2012
AbstractforAbsorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans | Full Text | References | PDF (1.2 MB)
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Article
Two novel creatinine adducts of andrographolide in human urine
Feng Qiu, Liang Cui, Lixia Chen, Jiawen Sun & Xinsheng Yao
Pages: 911-916
Published online: 09 May 2012
AbstractforTwo novel creatinine adducts of andrographolide in human urine | Full Text | References | PDF (873.3 KB)
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Animal Pharmacokinetics and Metabolism

Article
Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery
Helena Anna Thörn, Mohammed Yasin, Paul Alfred Dickinson & Hans Lennernäs
Pages: 917-928
Published online: 04 May 2012
AbstractforExtensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery | Full Text | References | PDF (1.2 MB)
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Article
Autoinduction of phase I and phase II metabolism of artemisinin in rats
J. Xing, F. Y. Du, T. Liu & F. P. Zhu
Pages: 929-938
Published online: 28 Mar 2012
AbstractforAutoinduction of phase I and phase II metabolism of artemisinin in rats | Full Text | References | PDF (777.7 KB)
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