Xenobiotica, Volume 43, Issue 12 (2013)

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Xenobiotica, Volume 43, Issue 12 (2013)

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General Xenobiochemistry

Article
Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans
Christopher R. Gibson, Ping Lu, Cheri Maciolek, Christen Wudarski, Zoe Barter, Karen Rowland-Yeo, Mark Stroh, Eseng Lai & Deborah A. Nicoll-Griffith
Pages: 1027-1036
Published online: 03 May 2013
AbstractforUsing human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans | Full Text | References | PDF (391 KB)
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Research Article

Article
Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline
Masahiro Utoh, Norie Murayama, Yasuhiro Uno, Yui Onose, Shinya Hosaka, Hideki Fujino, Makiko Shimizu, Kazuhide Iwasaki & Hiroshi Yamazaki
Pages: 1037-1042
Published online: 16 May 2013
AbstractforMonkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline | Full Text | References | PDF (373.3 KB)
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Article
Evaluation of in vitro metabolic systems for common drugs of abuse. 1. Cocaine
Kevin J. Schneider & Anthony P. DeCaprio
Pages: 1043-1054
Published online: 15 May 2013
AbstractforEvaluation of in vitro metabolic systems for common drugs of abuse. 1. Cocaine | Full Text | References | PDF (2.1 MB) | Supplemental
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Article
Hormonal regulation of Cyp4a isoforms in mouse liver and kidney
Youcai Zhang & Curtis D. Klaassen
Pages: 1055-1063
Published online: 31 May 2013
AbstractforHormonal regulation of Cyp4a isoforms in mouse liver and kidney | Full Text | References | PDF (331.9 KB)
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Article
Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues
Hitomi Ozaki, Kazumi Sugihara, Yoko Watanabe, Chieri Fujino, Naoto Uramaru, Tomomichi Sone, Shigeru Ohta & Shigeyuki Kitamura
Pages: 1064-1072
Published online: 06 Jun 2013
AbstractforComparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues | Full Text | References | PDF (1.4 MB)
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Clinical Pharmacokinetics and Metabolism

Article
Identification of domperidone metabolites in plasma and urine of gastroparesis patients with LC–ESI-MS/MS
Amir S. Youssef, Upendra A. Argikar, Murali Pathikonda, Henry P. Parkman & Swati Nagar
Pages: 1073-1083
Published online: 24 May 2013
AbstractforIdentification of domperidone metabolites in plasma and urine of gastroparesis patients with LC–ESI-MS/MS | Full Text | References | PDF (903.4 KB)
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Animal Pharmacokinetics and Metabolism

Article
Comparison of the in vitro and in vivo metabolism of Cladribine (Leustatin, Movectro) in animals and human
Holger Scheible, Marc Laisney, Elmar Wimmer, Ana Javornik & Hugues Dolgos
Pages: 1084-1094
Published online: 29 Apr 2013
AbstractforComparison of the in vitro and in vivo metabolism of Cladribine (Leustatin, Movectro) in animals and human | Full Text | References | PDF (1.6 MB)
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Research Article

Article
Pharmacokinetics and tissue distribution of furanodiene W/O/W multiple emulsions in rats by a fast and sensitive HPLC–APCI–MS/MS method
Li-Feng Zhang, Tao-Tao Lu, Shu-Qiu Zhang, Wen-Han Lin & Qing-Shan Li
Pages: 1095-1102
Published online: 02 May 2013
AbstractforPharmacokinetics and tissue distribution of furanodiene W/O/W multiple emulsions in rats by a fast and sensitive HPLC–APCI–MS/MS method | Full Text | References | PDF (613.7 KB)
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Molecular Toxicology

Article
Imbalance in redox system of rat liver following permethrin treatment in adolescence and neonatal age
Rosita Gabbianelli, Matyas Palan, Damian Jozef Flis, Donatella Fedeli, Cinzia Nasuti, Lucie Skarydova & Wieslaw Ziolkowski
Pages: 1103-1110
Published online: 28 May 2013
AbstractforImbalance in redox system of rat liver following permethrin treatment in adolescence and neonatal age | Full Text | References | PDF (248.6 KB)
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Acknowledgements

Article
Acknowledgements
Pages: 1111-1113
Published online: 31 Oct 2013
First Page PreviewforAcknowledgements | Full Text | PDF (83.1 KB)
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