Xenobiotica, Volume 43, Issue 6 (2013)

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Xenobiotica, Volume 43, Issue 6 (2013)

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General Xenobiochemistry

Article
A novel matrix for the short-term storage of cells: utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes
Anna-Pia Palmgren, Britt-Marie Fihn, James Bird, Paul Courtney & Ken Grime
Pages: 487-497
Published online: 09 Nov 2012
AbstractforA novel matrix for the short-term storage of cells: utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes | Full Text | References | PDF (927.6 KB)
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Article
Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design
Joseph W. Polli, Elizabeth Hussey, Mark Bush, Grant Generaux, Glenn Smith, David Collins, Susan McMullen, Nancy Turner & Derek J. Nunez
Pages: 498-508
Published online: 21 Dec 2012
AbstractforEvaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design | Full Text | References | PDF (700.5 KB)
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Article
Acute pulmonary effects of sidestream secondhand smoke at simulated car concentrations
Constantine I. Vardavas, Nektarios Anagnostopoulos, Marios Kougias, Vassiliki Evangelopoulou, Gregory N. Connolly & Panagiotis K. Behrakis
Pages: 509-513
Published online: 04 Dec 2012
AbstractforAcute pulmonary effects of sidestream secondhand smoke at simulated car concentrations | Full Text | References | PDF (569 KB)
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Article
2,5-Dihydroxy-4-methoxybenzophenone: a novel major in vitro metabolite of benzophenone-3 formed by rat and human liver microsomes
Nagisa Kamikyouden, Kazumi Sugihara, Yoko Watanabe, Naoto Uramaru, Tsuyoshi Murahashi, Masanori Kuroyanagi, Seigo Sanoh, Shigeru Ohta & Shigeyuki Kitamura
Pages: 514-519
Published online: 28 Nov 2012
Abstractfor2,5-Dihydroxy-4-methoxybenzophenone: a novel major in vitro metabolite of benzophenone-3 formed by rat and human liver microsomes | Full Text | References | PDF (704 KB)
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Article
Evaluation of low background liquid scintillation counter for non-clinical ADME studies
Akemi Onishi, Akifumi Kogame, Yoshihiko Tagawa, Takahiro Kondo & Satoru Asahi
Pages: 520-526
Published online: 21 Dec 2012
AbstractforEvaluation of low background liquid scintillation counter for non-clinical ADME studies | Full Text | References | PDF (725.1 KB)
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Article
Characterization of in vitro metabolites of luotonin A in human liver microsomes using electrospray/tandem mass spectrometry
Sangkyu Lee, Jaeick Lee, Yurngdong Jahng, Tae Cheon Jeong & Dong Hyun Kim
Pages: 527-533
Published online: 21 Dec 2012
AbstractforCharacterization of in vitro metabolites of luotonin A in human liver microsomes using electrospray/tandem mass spectrometry | Full Text | References | PDF (1.5 MB)
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Clinical Pharmacokinetics and Metabolism

Article
Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans
Tadashi Hashimoto, Katsuhiro Suzuki, Yukie Kihara, Takafumi Iwatsubo, Aiji Miyashita, Marten Heeringa, Hartmut Onkels, Dorien Groenendaal, Frank Verheggen, Sjoerd van Marle & Takashi Usui
Pages: 534-547
Published online: 20 Nov 2012
AbstractforAbsorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans | Full Text | References | PDF (987.2 KB)
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Animal Pharmacokinetics and Metabolism

Article
Application of a liquid chromatography-electrospray mass spectrometry (LC/MS) method to the biodistribution and excretion studies of novel 5′-chloro-2, 3-didehydroindolo (2′, 3′: 2, 3) betulinic acid (DRF-4012) in tumour-bearing mice
Gautam Mishra, Manoj Kumar Singh, Anshumali Awasthi, Anu T. Singh, Manu Jaggi & Farhan J. Ahmad
Pages: 548-560
Published online: 21 Dec 2012
AbstractforApplication of a liquid chromatography-electrospray mass spectrometry (LC/MS) method to the biodistribution and excretion studies of novel 5′-chloro-2, 3-didehydroindolo (2′, 3′: 2, 3) betulinic acid (DRF-4012) in tumour-bearing mice | Full Text | References | PDF (1.2 MB)
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Topics in Xenobiochemistry

Article
Contrasting toxicokinetic evaluations and interspecies pharmacokinetic scaling approaches for small molecules and biologics: applicability to biosimilar development
Elliot Offman & Andrea N. Edginton
Pages: 561-569
Published online: 17 Dec 2012
AbstractforContrasting toxicokinetic evaluations and interspecies pharmacokinetic scaling approaches for small molecules and biologics: applicability to biosimilar development | Full Text | References | PDF (591.9 KB)
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