Xenobiotica, Volume 43, Issue 8 (2013)

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Xenobiotica, Volume 43, Issue 8 (2013)

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General Xenobiochemistry

Article
Biomarkers of toluene exposure in rats: mercapturic acids versus traditional indicators (urinary hippuric acid and o-cresol and blood toluene)
Frédéric Cosnier, Benoît Cossec, Manuella Burgart, Hervé Nunge, Céline Brochard, Marie-Josèphe Décret & Aurélie Rémy
Pages: 651-660
Published online: 02 Jan 2013
AbstractforBiomarkers of toluene exposure in rats: mercapturic acids versus traditional indicators (urinary hippuric acid and o-cresol and blood toluene) | Full Text | References | PDF (299.5 KB)
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Research Article

Article
Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids
Maryam Hamzeh-Mivehroud, Seifullah Rahmani, Mohammad-Reza Rashidi, Mohammad-Ali Hosseinpour Feizi & Siavoush Dastmalchi
Pages: 661-670
Published online: 03 Jan 2013
AbstractforStructure-based investigation of rat aldehyde oxidase inhibition by flavonoids | Full Text | References | PDF (1.2 MB)
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Article
The volume of distribution is an indicator of poor in vitro–in vivo extrapolation of clearance for acidic drugs in the rat
Anna-Karin Sohlenius-Sternbeck, Urban Fagerholm & Johan Bylund
Pages: 671-678
Published online: 16 Jan 2013
AbstractforThe volume of distribution is an indicator of poor in vitro–in vivo extrapolation of clearance for acidic drugs in the rat | Full Text | References | PDF (402.5 KB)
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Article
Inhibitory effect of anthocyanidins on hepatic glutathione S-transferase, UDP-glucuronosyltransferase and carbonyl reductase activities in rat and human
Barbora Szotáková, Hana Bártíková, Jitka Hlaváčová, Iva Boušová & Lenka Skálová
Pages: 679-685
Published online: 15 Jan 2013
AbstractforInhibitory effect of anthocyanidins on hepatic glutathione S-transferase, UDP-glucuronosyltransferase and carbonyl reductase activities in rat and human | Full Text | References | PDF (213.3 KB)
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Article
Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs
Emanuela Puccinelli, Pier Giovanni Gervasi, Gualtiero Pelosi, Mariarita Puntoni & Vincenzo Longo
Pages: 686-698
Published online: 29 Jan 2013
AbstractforModulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs | Full Text | References | PDF (991.4 KB)
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Animal Pharmacokinetics and Metabolism

Article
Effect of amlodipine on the pharmacokinetics of tacrolimus in rats
Ya-nan Zhou, Bi-kui Zhang, Jing Li, Xiao-cong Zuo, Hong Yuan, Guo-ping Yang, Ze-neng Cheng, Zhi Liu, Pei-jiong Li, Hong-yi Tan, Ling-yun Zhou, Chung-jiang Wang & Meng Yang
Pages: 699-704
Published online: 11 Jan 2013
AbstractforEffect of amlodipine on the pharmacokinetics of tacrolimus in rats | Full Text | References | PDF (187.7 KB)
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Research Article

Article
Comparative single-dose pharmacokinetics of rasagiline in minipigs after oral dosing or transdermal administration via a newly developed patch
Yu Lin, Yanye Zou, Jialiang Lin, Tao Zhang & Jie Deng
Pages: 705-710
Published online: 23 Jan 2013
AbstractforComparative single-dose pharmacokinetics of rasagiline in minipigs after oral dosing or transdermal administration via a newly developed patch | Full Text | References | PDF (363.6 KB)
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Molecular Toxicology

Article
Chemical reactivity and biological activity of chalcones and other α,β-unsaturated carbonyl compounds
Daniela Maydt, Silke De Spirt, Christian Muschelknautz, Wilhelm Stahl & Thomas J. J. Müller
Pages: 711-718
Published online: 23 Jan 2013
AbstractforChemical reactivity and biological activity of chalcones and other α,β-unsaturated carbonyl compounds | Full Text | References | PDF (772.3 KB) | Supplemental
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Research Article

Article
Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice
Anwar Anwar-Mohamed, Ahmed El-Sherbeni, Seok Hee Kim, Osama H. Elshenawy, Hassan N. Althurwi, Beshay N. M. Zordoky & Ayman O. S. El-Kadi
Pages: 719-729
Published online: 15 Feb 2013
AbstractforAcute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice | Full Text | References | PDF (679.8 KB)
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Article
A safety study on single intravenous dose of tetrachloro-diphenyl glycoluril [iodogen] dissolved in dimethyl sulphoxide (DMSO)
Marlein Miranda Cona, Junjie Li, Feng Chen, Yuanbo Feng, Yeranddy Aguiar Alpizar, Florent Vanstapel, Karel Talavera, Peter de Witte, Alfons Verbruggen, Ziping Sun, Raymond Oyen & Yicheng Ni
Pages: 730-737
Published online: 08 Jan 2013
AbstractforA safety study on single intravenous dose of tetrachloro-diphenyl glycoluril [iodogen] dissolved in dimethyl sulphoxide (DMSO) | Full Text | References | PDF (1.1 MB)
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Xenobiotic Transporters

Article
Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2
Yejin Yu, Xiaoxiao Liu, Zheren Zhang, Yunpeng Xiao & Mei Hong
Pages: 738-744
Published online: 16 Jan 2013
AbstractforCloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2 | Full Text | References | PDF (1.1 MB)
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