Xenobiotica, Volume 43, Issue 9 (2013)

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Xenobiotica, Volume 43, Issue 9 (2013)

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General Xenobiochemistry

Article
Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract
C. Fernandez-Teruel, V. Mangas-Sanjuan, I. Gonzalez-Alvarez, A. Ruiz-Garcia, V. G. Casabó & M. Bermejo
Pages: 745-754
Published online: 08 Jan 2013
AbstractforMathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract | Full Text | References | PDF (1.2 MB)
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Research Article

Article
Cooperative effects for CYP2E1 differ between styrene and its metabolites
Jessica H. Hartman, Gunnar Boysen & Grover P. Miller
Pages: 755-764
Published online: 18 Jan 2013
AbstractforCooperative effects for CYP2E1 differ between styrene and its metabolites | Full Text | References | PDF (818.6 KB)
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Article
Time-dependent changes in hepatic and intestinal induction of cytochrome P450 3A after administration of dexamethasone to rats
Kazunori Iwanaga, Tatsuya Honjo, Makoto Miyazaki & Masawo Kakemi
Pages: 765-773
Published online: 23 Jan 2013
AbstractforTime-dependent changes in hepatic and intestinal induction of cytochrome P450 3A after administration of dexamethasone to rats | Full Text | References | PDF (427.8 KB)
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Article
Allometric scaling and prediction of concentration-time profiles of coagulation factors in humans from animals
Iftekhar Mahmood
Pages: 774-779
Published online: 07 Feb 2013
AbstractforAllometric scaling and prediction of concentration-time profiles of coagulation factors in humans from animals | Full Text | References | PDF (222.2 KB)
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Article
Activation of the anti-cancer agent upamostat by the mARC enzyme system
Danilo Froriep, Bernd Clement, Florian Bittner, Ralf R. Mendel, Debora Reichmann, Wolfgang Schmalix & Antje Havemeyer
Pages: 780-784
Published online: 04 Feb 2013
AbstractforActivation of the anti-cancer agent upamostat by the mARC enzyme system | Full Text | References | PDF (246.8 KB)
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Article
The utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport
Sanja Juric, Patrik Lundquist, Yin Hu, Anna Juréus & Anna-Karin Sohlenius-Sternbeck
Pages: 785-791
Published online: 09 Apr 2013
AbstractforThe utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport | Full Text | References | PDF (727.1 KB)
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Article
Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry
Toby J. Athersuch, Ian D. Wilson, Hector C. Keun & John C. Lindon
Pages: 792-802
Published online: 06 Feb 2013
AbstractforDevelopment of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry | Full Text | References | PDF (755 KB)
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Animal Pharmacokinetics and Metabolism

Article
Species-dependent metabolism of a novel selective α7 neuronal acetylcholine receptor agonist ABT-107
Hong Liu, Xiaoqing Deng, Jinrong Liu, Ning Liu, Patricia Stuart, Hongyu Xu, Zhiwen Guan, Kennan C. Marsh & Sonia M. De Morais
Pages: 803-816
Published online: 18 Jan 2013
AbstractforSpecies-dependent metabolism of a novel selective α7 neuronal acetylcholine receptor agonist ABT-107 | Full Text | References | PDF (341.2 KB)
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Research Article

Article
Biotransformation and pharmacokinetics of inositol hexanicotinate in rats
Shirlette G. Milton, Keila Robinson, Jing Ma, Bo Wei, Ivy O. Poon & Dong Liang
Pages: 817-822
Published online: 24 Jan 2013
AbstractforBiotransformation and pharmacokinetics of inositol hexanicotinate in rats | Full Text | References | PDF (221.8 KB)
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Article
ADME characterization in rats revealed immediate secretion of AZD7903 into the stomach after IV dosing
J. Haglund & N. Borg
Pages: 823-835
Published online: 07 Feb 2013
AbstractforADME characterization in rats revealed immediate secretion of AZD7903 into the stomach after IV dosing | Full Text | References | PDF (1.3 MB)
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Topics in Xenobiochemistry

Article Commentary
The pharmacokinetic interaction between mycophenolic acid and cyclosporine revisited: a commentary on “Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus”
Nicolas Picard
Pages: 836-838
Published online: 23 Jan 2013
First Page PreviewforThe pharmacokinetic interaction between mycophenolic acid and cyclosporine revisited: a commentary on “Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus” | Full Text | References | PDF (173.5 KB)
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