Xenobiotica, Volume 44, Issue 10 (2014)

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Xenobiotica, Volume 44, Issue 10 (2014)

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General Xenobiochemistry

Article
Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro
Tongya Yu, Xianzhi Chen, Yinjie Wang, Ruizhi Zhao & Shirui Mao
Pages: 861-867
Published online: 29 Apr 2014
AbstractforModulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro | Full Text | References | PDF (800.6 KB)
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Research Article

Article
Chlorpyrifos PBPK/PD model for multiple routes of exposure
Torka S. Poet, Charles Timchalk, Jon A. Hotchkiss & Michael J. Bartels
Pages: 868-881
Published online: 19 May 2014
AbstractforChlorpyrifos PBPK/PD model for multiple routes of exposure | Full Text | References | PDF (1.3 MB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism of propyrisulfuron: 14C excretion, 14C concentration in plasma and tissues, and amount of metabolites in rats
Tomoyuki Takaku, Kazuki Mikata, Hirohisa Nagahori & Yoshihisa Sogame
Pages: 882-892
Published online: 24 Mar 2014
AbstractforMetabolism of propyrisulfuron: 14C excretion, 14C concentration in plasma and tissues, and amount of metabolites in rats | Full Text | References | PDF (1.8 MB)
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Research Article

Article
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs
Takashi Koyanagi, Yoshiyuki Yamaura, Koji Yano, Soonih Kim & Hiroshi Yamazaki
Pages: 893-901
Published online: 21 Mar 2014
AbstractforAge-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs | Full Text | References | PDF (283 KB)
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Article
Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist
Rowan A. Stringer, Eckhard Weber, Andrew Culshaw, Jeff McKenna, Gareth Williams, Jonathan Rose & Bindi Sohal
Pages: 902-912
Published online: 03 Apr 2014
AbstractforPreclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist | Full Text | References | PDF (859.6 KB) | Supplemental
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Article
Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats
Tae Hwan Kim, Soyoung Shin, Mohammad Bashir, Yong Ha Chi, Soo Heui Paik, Joo Han Lee, Hyuk Joon Choi, Jin Ho Choi, Sun Dong Yoo, Jürgen B. Bulitta, Eunsook Ma, Sang Hoon Joo & Beom Soo Shin
Pages: 913-925
Published online: 30 Apr 2014
AbstractforPharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats | Full Text | References | PDF (1.6 MB) | Supplemental
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Xenobiotic Transporters

Article
Impact of genetic deficiencies of P-glycoprotein and breast cancer resistance protein on pharmacokinetics of aripiprazole and dehydroaripiprazole
Yasuhisa Nagasaka, Tomokazu Sano, Kazuo Oda, Akio Kawamura & Takashi Usui
Pages: 926-932
Published online: 26 Mar 2014
AbstractforImpact of genetic deficiencies of P-glycoprotein and breast cancer resistance protein on pharmacokinetics of aripiprazole and dehydroaripiprazole | Full Text | References | PDF (241.9 KB)
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Research Article

Article
Association analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C3435T) and their genotype/haplotype combinations with the familial Mediterranean fever
Aydin Rustemoglu, Guvem Gumus-Akay, Nevin Karakus, Serbulent Yigit, Server Sahin & Turker Tasliyurt
Pages: 933-940
Published online: 28 Apr 2014
AbstractforAssociation analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C3435T) and their genotype/haplotype combinations with the familial Mediterranean fever | Full Text | References | PDF (253.4 KB)
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Article
Temporal expression of transporters and receptors in a rat primary co-culture blood–brain barrier model
Houfu Liu, Yang Li, Sijie Lu, Yiwen Wu & Jasminder Sahi
Pages: 941-951
Published online: 14 May 2014
AbstractforTemporal expression of transporters and receptors in a rat primary co-culture blood–brain barrier model | Full Text | References | PDF (745.2 KB)
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Pharmacogenetics

Article
Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism
Ahmet Inanir, Nevin Karakus, Omer Ates, Saime Sezer, Nihan Bozkurt, Sema Inanir & Serbulent Yigit
Pages: 952-956
Published online: 24 Apr 2014
AbstractforClinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism | Full Text | References | PDF (122.4 KB)
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