Xenobiotica, Volume 44, Issue 2 (2014)

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Xenobiotica, Volume 44, Issue 2 (2014)

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Preface

Article
The phoenix rises: a new science of in vivo drug metabolism
Kristin Samuelsson & Ian D. Wilson
Page: 95
Published online: 22 Jan 2014
CitationforThe phoenix rises: a new science of in vivo drug metabolism | Full Text | PDF (82.5 KB)
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Free Access

Review Article

Review Article
Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications
Nico Scheer & C. Roland Wolf
Pages: 96-108
Published online: 11 Jul 2013
AbstractforGenetically humanized mouse models of drug metabolizing enzymes and transporters and their applications | Full Text | References | PDF (529.4 KB)
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Review Article
Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies
John R. Foster, Garry Lund, Svetlana Sapelnikova, D. Lorne Tyrrell & Norman M. Kneteman
Pages: 109-122
Published online: 10 Dec 2013
AbstractforChimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies | Full Text | References | PDF (299.5 KB)
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Review Article
Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver
Shigeyuki Kitamura & Kazumi Sugihara
Pages: 123-134
Published online: 13 Dec 2013
AbstractforCurrent status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver | Full Text | References | PDF (1 MB)
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Review Article
Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid
Marie Stiborová, Eva Frei, Volker M. Arlt & Heinz H. Schmeiser
Pages: 135-145
Published online: 23 Oct 2013
AbstractforKnockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid | Full Text | References | PDF (441 KB)
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Research Article

Article
The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice
Yuichiro Higuchi, Kenji Kawai, Hiroshi Yamazaki, Masato Nakamura, Françoise Bree, Christiane Guguen-Guillouzo & Hiroshi Suemizu
Pages: 146-153
Published online: 25 Sep 2013
AbstractforThe human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice | Full Text | References | PDF (1.6 MB) | Supplemental
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Open Access
Article
In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver
Yoshiyuki Igawa, Tomomichi Fujitani, Bharti Shah, Charles Oo & Yasushi Kanai
Pages: 154-163
Published online: 04 Dec 2013
AbstractforIn vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver | Full Text | References | PDF (607.9 KB)
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Article
The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse
Kathryn Pickup, Jonathan Wills, Alison Rodrigues, Huw B. Jones, Chris Page, Scott Martin, Sunil Sarda & Ian Wilson
Pages: 164-173
Published online: 10 Dec 2013
AbstractforThe metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse | Full Text | References | PDF (453.1 KB)
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Article
Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone
Alan J. Barnes, David R. Baker, Kirsten Hobby, Simon Ashton, Filippos Michopoulos, Konstantina Spagou, Neil J. Loftus & Ian D. Wilson
Pages: 174-185
Published online: 18 Dec 2013
AbstractforEndogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone | Full Text | References | PDF (1.7 MB)
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Article
Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice
Kristin Samuelsson, Kathryn Pickup, Sunil Sarda, John R. Foster, Kevin Randall, Anna Abrahamsson, Matt Jacobsen, Lars Weidolf & Ian Wilson
Pages: 186-195
Published online: 13 Jan 2014
AbstractforTroglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice | Full Text | References | PDF (1 MB)
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