Xenobiotica, Volume 44, Issue 5 (2014)

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Xenobiotica, Volume 44, Issue 5 (2014)

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General Xenobiochemistry

Article
In vitro metabolism of thyroxine by rat and human hepatocytes
Vicki M. Richardson, Stephen S. Ferguson, Yusupha M. Sey & Michael J. DeVito
Pages: 391-403
Published online: 31 Oct 2013
AbstractforIn vitro metabolism of thyroxine by rat and human hepatocytes | Full Text | References | PDF (439.6 KB)
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Research Article

Article
Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors
Yan-Yan Zhang, Yong Liu, Shahila Mehboob, Jin-Hua Song, Teuta Boci, Michael E. Johnson, Arun K. Ghosh & Hyunyoung Jeong
Pages: 404-416
Published online: 30 Oct 2013
AbstractforMetabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors | Full Text | References | PDF (1.2 MB)
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Article
Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters
Sophia Yui Kau Fong & Zhong Zuo
Pages: 417-431
Published online: 30 Oct 2013
AbstractforSpecies difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters | Full Text | References | PDF (1.7 MB)
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Article
The abundant dietary constituent ferulic acid forms a wide range of metabolites including a glutathione adduct when incubated with rat hepatocytes
Khaled Omar, M. Helen Grant, Catherine Henderson & David G. Watson
Pages: 432-437
Published online: 06 Nov 2013
AbstractforThe abundant dietary constituent ferulic acid forms a wide range of metabolites including a glutathione adduct when incubated with rat hepatocytes | Full Text | References | PDF (479 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Metabolism and clinical pharmacokinetics of 2-methyl-n-(2′-(pyrrolidinyl-1-ylsulfonyl)-n-[1,1′-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools
Aarti Sawant Basak, Wonkyung Byon, Elaine Tseng-Lovering, Carrie Funk, Linda Wood, Chang Lin, Marielle Delnomdedieu, Patrick Verhoest, Vinod Parikh, Loretta M. Cox, Emily Miller, Hongying Gao & Ronald S. Obach
Pages: 438-454
Published online: 04 Dec 2013
AbstractforMetabolism and clinical pharmacokinetics of 2-methyl-n-(2′-(pyrrolidinyl-1-ylsulfonyl)-n-[1,1′-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools | Full Text | References | PDF (761.8 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolite elucidation of the Hsp90 inhibitor SNX-2112 using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS)
Wei Liu, Hongming Liu, Hua Sun, Dong Dong, Zhiguo Ma, Yifei Wang & Baojian Wu
Pages: 455-464
Published online: 05 Nov 2013
AbstractforMetabolite elucidation of the Hsp90 inhibitor SNX-2112 using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) | Full Text | References | PDF (2.2 MB) | Supplemental
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Research Article

Article
Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor
Eun-Young Kwak, So Hee Im, Hyewon Seo, Woon-Ki Cho, Ye-Lim Lee, Jaechun Woo, Sunjoo Ahn, Sung-Hoon Ahn, Hyun Jung Kwak, Jin Hee Ahn, Myung Ae Bae & Jin Sook Song
Pages: 465-471
Published online: 23 Oct 2013
AbstractforPreclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor | Full Text | References | PDF (279.5 KB)
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Xenobiotic Transporters

Article
Effects of age on multidrug resistance protein expression and doxorubicin accumulation in cardiac and skeletal muscle
Noah M. Gibson, Colin J. Quinn, Keith B. Pfannenstiel, David S. Hydock & Reid Hayward
Pages: 472-479
Published online: 18 Oct 2013
AbstractforEffects of age on multidrug resistance protein expression and doxorubicin accumulation in cardiac and skeletal muscle | Full Text | References | PDF (714.8 KB)
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Topics in Xenobiochemistry

Review Article
Folate, folic acid and 5-methyltetrahydrofolate are not the same thing
Francesco Scaglione & Giscardo Panzavolta
Pages: 480-488
Published online: 04 Feb 2014
AbstractforFolate, folic acid and 5-methyltetrahydrofolate are not the same thing | Full Text | References | PDF (588.2 KB)
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