Xenobiotica, Volume 44, Issue 8 (2014)

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Xenobiotica, Volume 44, Issue 8 (2014)

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General Xenobiochemistry

Article
Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes
Norimasa Jinno, Mizuka Tagashira, Kazuyuki Tsurui & Shizuo Yamada
Pages: 677-686
Published online: 27 Feb 2014
AbstractforContribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes | Full Text | References | PDF (237.8 KB) | Supplemental
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Research Article

Article
Identification of saturated and unsaturated fatty acids released during microsomal incubations
Jennifer L. Bushee, Guiqing Liang, Christine E. Dunne, Shawn P. Harriman & Upendra A. Argikar
Pages: 687-695
Published online: 06 Feb 2014
AbstractforIdentification of saturated and unsaturated fatty acids released during microsomal incubations | Full Text | References | PDF (541.5 KB)
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Article
Identification of glucuronidation and biliary excretion as the main mechanisms for gossypol clearance: in vivo and in vitro evidence
Hongming Liu, Hua Sun, Danyi Lu, Yuchen Zhang, Xingwang Zhang, Zhiguo Ma & Baojian Wu
Pages: 696-707
Published online: 20 Feb 2014
AbstractforIdentification of glucuronidation and biliary excretion as the main mechanisms for gossypol clearance: in vivo and in vitro evidence | Full Text | References | PDF (1.2 MB)
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Article
Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression
Jana Nekvindova, Juan Antonio Contreras, Peter Juvan, Klementina Fon Tacer, Pavel Anzenbacher, Zdenek Zidek, Michaela Kopecna Zapletalova, Damjana Rozman & Eva Anzenbacherova
Pages: 708-715
Published online: 05 Mar 2014
AbstractforAcyclic nucleoside phosphonates: a study on cytochrome P450 gene expression | Full Text | References | PDF (393.4 KB)
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Article
Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences
Bao-Li Mi, Qi Sun, Yan-Qing Qu, Xiao-Xu Gao, Zhen-Wen Yu, Guang-Bo Ge, Shan-Shan Cai, Jie Zhang, Yan-Chao Zheng & Zhen-Qiu Zhang
Pages: 716-721
Published online: 11 Mar 2014
AbstractforGlucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences | Full Text | References | PDF (336.6 KB)
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Article
Effect of commonly used organic solvents on Aldehyde oxidase-mediated Vanillin, Phthalazine and Methotrexate oxidation in human, rat and mouse liver subcellular fractions
Dayanidhi Behera, Rambabu Pattem & Girish Gudi
Pages: 722-733
Published online: 17 Feb 2014
AbstractforEffect of commonly used organic solvents on Aldehyde oxidase-mediated Vanillin, Phthalazine and Methotrexate oxidation in human, rat and mouse liver subcellular fractions | Full Text | References | PDF (1.2 MB)
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Clinical Pharmacokinetics and Metabolism

Article
Structure identification and elucidation of mosapride metabolites in human urine, feces and plasma by ultra performance liquid chromatography-tandem mass spectrometry method
Xiaohong Sun, Longshan Zhao, Lili Niu, Feng Qin, Xiumei Lu, Zhili Xiong & Famei Li
Pages: 734-742
Published online: 13 Jan 2014
AbstractforStructure identification and elucidation of mosapride metabolites in human urine, feces and plasma by ultra performance liquid chromatography-tandem mass spectrometry method | Full Text | References | PDF (1,003.5 KB)
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Animal Pharmacokinetics and Metabolism

Article
Gradient elution liquid chromatography mass spectrometry determination of acetylcorynoline in rat plasma and its application to a pharmacokinetic study
Congcong Wen, Jinzhang Cai, Chongliang Lin, Jianshe Ma & Xianqin Wang
Pages: 743-748
Published online: 10 Feb 2014
AbstractforGradient elution liquid chromatography mass spectrometry determination of acetylcorynoline in rat plasma and its application to a pharmacokinetic study | Full Text | References | PDF (449.6 KB)
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Research Article

Article
Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application
Suramya Waidyanatha & Kristen Ryan
Pages: 749-756
Published online: 17 Feb 2014
AbstractforDisposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application | Full Text | References | PDF (269.5 KB)
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Article
Investigation on pharmacokinetics, tissue distribution and excretion of a novel platinum anticancer agent in rats by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Jie Zhao, Yanli Wen, Wei Zhang, Di Zhao, Ali Fan, Yongjie Zhang, Shuhua Deng, Xin Wang, Qingwang Liu, Yang Lu, Zhimei Wang, Shaohua Gou & Xijing Chen
Pages: 757-762
Published online: 14 Feb 2014
AbstractforInvestigation on pharmacokinetics, tissue distribution and excretion of a novel platinum anticancer agent in rats by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Full Text | References | PDF (271.7 KB)
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Xenobiotic Transporters

Article
P-glycoprotein (P-gp)-mediated efflux limits intestinal absorption of the Hsp90 inhibitor SNX-2112 in rats
Hongming Liu, Hua Sun, Zhufeng Wu, Xingwang Zhang & Baojian Wu
Pages: 763-768
Published online: 20 Feb 2014
AbstractforP-glycoprotein (P-gp)-mediated efflux limits intestinal absorption of the Hsp90 inhibitor SNX-2112 in rats | Full Text | References | PDF (254.5 KB)
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