Xenobiotica, Volume 45, Issue 11 (2015)

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Xenobiotica, Volume 45, Issue 11 (2015)

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General Xenobiochemistry

Article
Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells
Hua Sun, Xiaotong Zhou & Baojian Wu
Pages: 945-953
Published online: 11 Jun 2015
AbstractforAccurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells | Full Text | References | PDF (422.6 KB)
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Article
Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human
Jing Ning, Jie Hou, Ping Wang, Jing-Jing Wu, Zi-Ru Dai, Li-Wei Zou, Wei Li, Guang-Bo Ge, Xiao-Chi Ma & Ling Yang
Pages: 954-960
Published online: 08 Jun 2015
AbstractforInterspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human | Full Text | References | PDF (466.1 KB)
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Article
A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug–drug interaction evaluation
Ying Peng, Hui Wu, Xueyuan Zhang, Fengyi Zhang, Huanhuan Qi, Yunxi Zhong, Yu Wang, Hua Sang, Guangji Wang & Jianguo Sun
Pages: 961-977
Published online: 26 May 2015
AbstractforA comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug–drug interaction evaluation | Full Text | References | PDF (2.7 MB) | Supplemental
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Article
Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine
Fang-Liang Zhang, Xin He, Yi-Ran Zhai, Li-Na He, Si-Chao Zhang, Li-Li Wang, Ai-Hong Yang & Li-Jun An
Pages: 978-989
Published online: 08 Jun 2015
AbstractforMechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine | Full Text | References | PDF (1.1 MB)
  • 346 Views
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Article
In vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7
Larry House, Jacqueline Ramirez, Michael Seminerio, Snezana Mirkov & Mark J. Ratain
Pages: 990-998
Published online: 08 Jun 2015
AbstractforIn vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7 | Full Text | References | PDF (698.3 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration
Peiying Shi, Xinhua Lin & Hong Yao
Pages: 999-1008
Published online: 18 Jun 2015
AbstractforMetabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Evaluating the enantioselective distribution, degradation and excretion of epoxiconazole in mice following a single oral gavage
Dezhen Wang, Jing Qiu, Wentao Zhu, Ping Zhang, Nian Deng, Xinru Wang, Yao Wang & Zhiqiang Zhou
Pages: 1009-1015
Published online: 25 Jun 2015
AbstractforEvaluating the enantioselective distribution, degradation and excretion of epoxiconazole in mice following a single oral gavage | Full Text | References | PDF (583.3 KB)
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Article
Pharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits
Amrita Saxena, Guru R. Valicherla, Pankaj Joshi, Rohit Saxena, Srikanth H. Cheruvu, Shome S. Bhunia, Girish K. Jain, Hefazat H. Siddiqui, Anil K. Saxena & Jiaur R. Gayen
Pages: 1016-1023
Published online: 18 Jun 2015
AbstractforPharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits | Full Text | References | PDF (681.3 KB)
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Molecular Toxicology

Article
Protective effects of berberine against doxorubicin-induced cardiotoxicity in rats by inhibiting metabolism of doxorubicin
Gang Hao, Yunli Yu, Bingren Gu, Yiwen Xing & Man Xue
Pages: 1024-1029
Published online: 13 May 2015
AbstractforProtective effects of berberine against doxorubicin-induced cardiotoxicity in rats by inhibiting metabolism of doxorubicin | Full Text | References | PDF (553.3 KB)
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Pharmacogenetics

Article
In vitro functional analysis of 24 novel CYP2C19 variants recently found in the Chinese Han population
Da-Peng Dai, Li-Ming Hu, Pei-Wu Geng, Shuang-Hu Wang, Jie Cai, Guo-Xin Hu & Jian-Ping Cai
Pages: 1030-1035
Published online: 07 Jul 2015
AbstractforIn vitro functional analysis of 24 novel CYP2C19 variants recently found in the Chinese Han population | Full Text | References | PDF (402.4 KB)
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