Xenobiotica, Volume 45, Issue 2 (2015)

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Xenobiotica, Volume 45, Issue 2 (2015)

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Research Article

Article
Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays
Ramakrishna Nirogi, Raghava Choudary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Surya Rao Srikakolapu, Ilayaraja Kalaikadhiban, Rajesh Kumar Boggavarapu, Ranjith Kumar Ponnamaneni, Devender Reddy Ajjala & Gopinadh Bhyrapuneni
Pages: 95-106
Published online: 29 Jul 2014
AbstractforChemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays | Full Text | References | PDF (1.5 MB)
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Article
Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite
Joel A. Krauser, Yi Jin, Markus Walles, Ulrike Pfaar, James Sutton, Marion Wiesmann, Daniel Graf, Veronique Pflimlin-Fritschy, Thierry Wolf, Gian Camenisch & Piet Swart
Pages: 107-123
Published online: 02 Sep 2014
AbstractforPhenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite | Full Text | References | PDF (1.1 MB)
  • 1154 Views
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Article
Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine
Shotaro Uehara, Norie Murayama, Yasuharu Nakanishi, Chika Nakamura, Takanori Hashizume, Darryl C. Zeldin, Hiroshi Yamazaki & Yasuhiro Uno
Pages: 124-130
Published online: 20 Aug 2014
AbstractforImmunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine | Full Text | References | PDF (391 KB)
  • 298 Views
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Article
Inhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes
Sang Yoon Lee, Himchan Jang, Ji-Yoon Lee, Jin Yeul Ma, Soo Jin Oh & Sang Kyum Kim
Pages: 131-138
Published online: 22 Aug 2014
AbstractforInhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes | Full Text | References | PDF (647.1 KB)
  • 335 Views
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Article
Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans
Maribel Reyes, Matthias Hoch, Patrick Brossard, Winfried Wagner-Redeker, Tommaso Miraval & Jasper Dingemanse
Pages: 139-149
Published online: 04 Sep 2014
AbstractforMass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans | Full Text | References | PDF (892.3 KB)
  • 555 Views
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Article
The metabolism and pharmacokinetics of [14C]-S-777469, a new cannabinoid receptor 2 selective agonist, in healthy human subjects
Kazutaka Sekiguchi, Kazuya Fukumura, Hiroshi Hasegawa & Takushi Kanazu
Pages: 150-157
Published online: 02 Sep 2014
AbstractforThe metabolism and pharmacokinetics of [14C]-S-777469, a new cannabinoid receptor 2 selective agonist, in healthy human subjects | Full Text | References | PDF (627.4 KB)
  • 385 Views
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Article
In vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase
Jian Guo, Camil Joubran, Ricardo A. Luzietti Jr., Fei Zhou, Gregory S. Basarab & Karthick Vishwanathan
Pages: 158-170
Published online: 21 Aug 2014
AbstractforIn vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase | Full Text | References | PDF (1,018.8 KB)
  • 241 Views
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Article
Effects of capsaicin on pharmacokinetics of pitavastatin in rats
Fen Chen, Xuejia Zhai, Chaoran Zhu & Yongning Lu
Pages: 171-176
Published online: 04 Sep 2014
AbstractforEffects of capsaicin on pharmacokinetics of pitavastatin in rats | Full Text | References | PDF (868.7 KB)
  • 309 Views
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Article
Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture
Lassina Badolo, Bente Jensen, Carolina Säll, Ulf Norinder, Pekka Kallunki & Dino Montanari
Pages: 177-187
Published online: 03 Sep 2014
AbstractforEvaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture | Full Text | References | PDF (306.9 KB) | Supplemental
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