Xenobiotica, Volume 45, Issue 9 (2015)

Browse this journal
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Xenobiotica, Volume 45, Issue 9 (2015)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Volume 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome
Martin Poruba, Ludmila Kazdová, Olena Oliyarnyk, Hana Malinská, Zuzana Matusková, Igor Tozzi di Angelo, Vojtech Skop & Rostislav Vecera
Pages: 751-756
Published online: 11 Jun 2015
AbstractforImprovement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome | Full Text | References | PDF (286.3 KB)
  • 244 Views
  • 16 CrossRef citations
  • 0Altmetric
Article
Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans
Naoyuki Nakada & Kazuo Oda
Pages: 757-765
Published online: 14 Apr 2015
AbstractforIdentification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans | Full Text | References | PDF (655.3 KB)
  • 956 Views
  • 10 CrossRef citations
  • 0Altmetric
Article
Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan
Shotaro Uehara, Yasuhiro Uno, Yuya Hagihira, Norie Murayama, Makiko Shimizu, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki
Pages: 766-772
Published online: 24 Mar 2015
AbstractforMarmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan | Full Text | References | PDF (294.5 KB)
  • 389 Views
  • 23 CrossRef citations
  • 0Altmetric
Article
Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines
Cong Xu, Mengyue Luo, Huidi Jiang, Lushan Yu & Su Zeng
Pages: 773-781
Published online: 14 Apr 2015
AbstractforInvolvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines | Full Text | References | PDF (606.8 KB)
  • 844 Views
  • 11 CrossRef citations
  • 0Altmetric
Article
Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway
Ruini Chen, Yuwen Wang, Rui Ning, Jinhua Hu, Wei Liu, Jing Xiong, Lili Wu, Jie Liu, Gang Hu & Jian Yang
Pages: 782-793
Published online: 24 Mar 2015
AbstractforDecreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway | Full Text | References | PDF (1.4 MB)
  • 795 Views
  • 19 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution
Feng Li, Dan Xu, Nan Shu, Zeyu Zhong, Mian Zhang, Can Liu, Zhaoli Ling, Li Liu & Xiaodong Liu
Pages: 794-802
Published online: 27 Apr 2015
AbstractforCo-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution | Full Text | References | PDF (716 KB)
  • 369 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Effects of four traditional Chinese medicines on the pharmacokinetics of simvastatin
Qian Zhao, Ji Jiang & Pei Hu
Pages: 803-810
Published online: 24 Mar 2015
AbstractforEffects of four traditional Chinese medicines on the pharmacokinetics of simvastatin | Full Text | References | PDF (252.9 KB)
  • 554 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration
Suramya Waidyanatha, James M. Mathews, Purvi R. Patel, Sherry R. Black, Rodney W. Snyder & Timothy R. Fennell
Pages: 811-819
Published online: 29 Apr 2015
AbstractforDisposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration | Full Text | References | PDF (275.6 KB) | Supplemental
  • 875 Views
  • 20 CrossRef citations
  • 0Altmetric

Xenobiotic transporters

Article
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats
Qu Qi, Lijuan Cao, Feiyan Li, Hong Wang, Huiying Liu, Haiping Hao & Kun Hao
Pages: 820-827
Published online: 14 Apr 2015
AbstractforSalvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats | Full Text | References | PDF (543.4 KB)
  • 245 Views
  • 4 CrossRef citations
  • 0Altmetric
Article
Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat
Ana I. Loureiro, Maria João Bonifácio, Carlos Fernandes-Lopes, Nuno Pires, Bruno Igreja, Lyndon C. Wright & Patrício Soares-da-Silva
Pages: 828-839
Published online: 27 Apr 2015
AbstractforRole of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat | Full Text | References | PDF (864.2 KB)
  • 443 Views
  • 8 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients
LiQin Zhu, JianWei Yang, Yuan Zhang, YaQing Jing, YanWen Zhang & Guang Li
Pages: 840-846
Published online: 14 Apr 2015
AbstractforEffects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients | Full Text | References | PDF (502.9 KB)
  • 802 Views
  • 34 CrossRef citations
  • 0Altmetric

Explore articles