Xenobiotica, Volume 45, Issue 9 (2015)

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Xenobiotica, Volume 45, Issue 9 (2015)

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General Xenobiochemistry

Article
Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome
Martin Poruba, Ludmila Kazdová, Olena Oliyarnyk, Hana Malinská, Zuzana Matusková, Igor Tozzi di Angelo, Vojtech Skop & Rostislav Vecera
Pages: 751-756
Published online: 11 Jun 2015
AbstractforImprovement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome | Full Text | References | PDF (286.3 KB)
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Article
Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans
Naoyuki Nakada & Kazuo Oda
Pages: 757-765
Published online: 14 Apr 2015
AbstractforIdentification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans | Full Text | References | PDF (655.3 KB)
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Article
Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan
Shotaro Uehara, Yasuhiro Uno, Yuya Hagihira, Norie Murayama, Makiko Shimizu, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki
Pages: 766-772
Published online: 24 Mar 2015
AbstractforMarmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan | Full Text | References | PDF (294.5 KB)
  • 216 Views
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Article
Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines
Cong Xu, Mengyue Luo, Huidi Jiang, Lushan Yu & Su Zeng
Pages: 773-781
Published online: 14 Apr 2015
AbstractforInvolvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines | Full Text | References | PDF (606.8 KB)
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Article
Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway
Ruini Chen, Yuwen Wang, Rui Ning, Jinhua Hu, Wei Liu, Jing Xiong, Lili Wu, Jie Liu, Gang Hu & Jian Yang
Pages: 782-793
Published online: 24 Mar 2015
AbstractforDecreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway | Full Text | References | PDF (1.4 MB)
  • 450 Views
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Animal Pharmacokinetics and Metabolism

Article
Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution
Feng Li, Dan Xu, Nan Shu, Zeyu Zhong, Mian Zhang, Can Liu, Zhaoli Ling, Li Liu & Xiaodong Liu
Pages: 794-802
Published online: 27 Apr 2015
AbstractforCo-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution | Full Text | References | PDF (716 KB)
  • 221 Views
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Article
Effects of four traditional Chinese medicines on the pharmacokinetics of simvastatin
Qian Zhao, Ji Jiang & Pei Hu
Pages: 803-810
Published online: 24 Mar 2015
AbstractforEffects of four traditional Chinese medicines on the pharmacokinetics of simvastatin | Full Text | References | PDF (252.9 KB)
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Article
Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration
Suramya Waidyanatha, James M. Mathews, Purvi R. Patel, Sherry R. Black, Rodney W. Snyder & Timothy R. Fennell
Pages: 811-819
Published online: 29 Apr 2015
AbstractforDisposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration | Full Text | References | PDF (275.6 KB) | Supplemental
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Xenobiotic transporters

Article
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats
Qu Qi, Lijuan Cao, Feiyan Li, Hong Wang, Huiying Liu, Haiping Hao & Kun Hao
Pages: 820-827
Published online: 14 Apr 2015
AbstractforSalvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats | Full Text | References | PDF (543.4 KB)
  • 147 Views
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Article
Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat
Ana I. Loureiro, Maria João Bonifácio, Carlos Fernandes-Lopes, Nuno Pires, Bruno Igreja, Lyndon C. Wright & Patrício Soares-da-Silva
Pages: 828-839
Published online: 27 Apr 2015
AbstractforRole of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat | Full Text | References | PDF (864.2 KB)
  • 251 Views
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Pharmacogenetics

Article
Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients
LiQin Zhu, JianWei Yang, Yuan Zhang, YaQing Jing, YanWen Zhang & Guang Li
Pages: 840-846
Published online: 14 Apr 2015
AbstractforEffects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients | Full Text | References | PDF (502.9 KB)
  • 455 Views
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