Xenobiotica, Volume 46, Issue 11 (2016)

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Xenobiotica, Volume 46, Issue 11 (2016)

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General Xenobiochemistry

Article
Single concentration loss of activity assay provides an improved assessment of drug–drug interaction risk compared to IC50-shift
Simon G. Wong, Mey Lee & Bradley K. Wong
Pages: 953-966
Published online: 09 Mar 2016
AbstractforSingle concentration loss of activity assay provides an improved assessment of drug–drug interaction risk compared to IC50-shift | Full Text | References | PDF (1 MB)
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Article
Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib
Yumi Nishiya, Daisuke Nakai, Yoko Urasaki, Hideo Takakusa, Satoru Ohsuki, Yuji Iwano, Takanori Yasukochi, Tomoko Takayama, Shohei Bazyo, Chikahiro Oza, Atsushi Kurihara, Ronald E Savage & Takashi Izumi
Pages: 967-976
Published online: 22 Feb 2016
AbstractforStereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib | Full Text | References | PDF (1,012.6 KB)
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Article
Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine
Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Eriko Okamoto, Erika Sasaki & Hiroshi Yamazaki
Pages: 977-985
Published online: 22 Feb 2016
AbstractforMarmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine | Full Text | References | PDF (619.3 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects
Jimmy Flarakos, Yancy Du, Timothy Bedman, Qusai Al-Share, Pierre Jordaan, Priya Chandra, Diego Albrecht, Lai Wang, Helen Gu, Heidi J. Einolf, Su-Er Huskey & James B. Mangold
Pages: 986-1000
Published online: 02 Mar 2016
AbstractforDisposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects | Full Text | References | PDF (2 MB) | Supplemental
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Article
Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers
Madhu Sanga, John Banach, Aaron Ledvina, Nishit B. Modi & Aravind Mittur
Pages: 1001-1016
Published online: 21 Jan 2016
AbstractforPharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers | Full Text | References | PDF (1.3 MB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs
Hirotaka Amano, Daichi Kazamori & Kenji Itoh
Pages: 1017-1025
Published online: 17 Feb 2016
AbstractforPharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs | Full Text | References | PDF (274.3 KB)
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Article
Pharmacokinetics, distribution, metabolism, and excretion of the dual reuptake inhibitor [14C]-nefopam in rats
Jian Yu, Eric Solon, Helen Shen, Nishit B. Modi & Aravind Mittur
Pages: 1026-1048
Published online: 29 Feb 2016
AbstractforPharmacokinetics, distribution, metabolism, and excretion of the dual reuptake inhibitor [14C]-nefopam in rats | Full Text | References | PDF (3.1 MB) | Supplemental
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