Xenobiotica, Volume 46, Issue 12 (2016)

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Xenobiotica, Volume 46, Issue 12 (2016)

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General Xenobiochemistry

Article
Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling
Masahiro Utoh, Hiroshi Suemizu, Marina Mitsui, Mirai Kawano, Akiko Toda, Shotaro Uehara, Yasuhiro Uno, Makiko Shimizu, Erika Sasaki & Hiroshi Yamazaki
Pages: 1049-1055
Published online: 25 Feb 2016
AbstractforHuman plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling | Full Text | References | PDF (772.4 KB)
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Article
Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumor triazoloacridinone C-1305
Agnieszka Potęga, Barbara Fedejko-Kap & Zofia Mazerska
Pages: 1056-1065
Published online: 29 Feb 2016
AbstractforMechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumor triazoloacridinone C-1305 | Full Text | References | PDF (743.6 KB)
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Article
Optimization of a UDP-glucuronosyltransferase assay for trout liver S9 fractions: activity enhancement by alamethicin, a pore-forming peptide
Melanie A. Ladd, Patrick N. Fitzsimmons & John W. Nichols
Pages: 1066-1075
Published online: 07 Mar 2016
AbstractforOptimization of a UDP-glucuronosyltransferase assay for trout liver S9 fractions: activity enhancement by alamethicin, a pore-forming peptide | Full Text | References | PDF (479.3 KB)
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Article
Prediction of drug–drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition
Maria Rosa, Pierre Bonnaillie & Hugues Chanteux
Pages: 1076-1084
Published online: 03 Mar 2016
AbstractforPrediction of drug–drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition | Full Text | References | PDF (324.2 KB)
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Article
Sodium tanshinone IIA sulfonate and its interactions with human CYP450s
D. Chen, X.-X. Lin, W.-H. Huang, W. Zhang, Z.-R. Tan, J.-B. Peng, Y.-C. Wang, Y. Guo, D.-L. Hu & Y. Chen
Pages: 1085-1092
Published online: 02 Mar 2016
AbstractforSodium tanshinone IIA sulfonate and its interactions with human CYP450s | Full Text | References | PDF (409.6 KB)
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Article
Physiologically based pharmacokinetic model of docetaxel and interspecies scaling: comparison of simple injection with folate receptor-targeting amphiphilic copolymer-modified liposomes
Xue-Feng Lu, Kaishun Bi & Xiaohui Chen
Pages: 1093-1104
Published online: 17 Mar 2016
AbstractforPhysiologically based pharmacokinetic model of docetaxel and interspecies scaling: comparison of simple injection with folate receptor-targeting amphiphilic copolymer-modified liposomes | Full Text | References | PDF (810.4 KB) | Supplemental
  • 412 Views
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Article
A unified strategy in selection of the best allometric scaling methods to predict human clearance based on drug disposition pathway
Dongyang Liu, Hanlin Song, Ling Song, Yang Liu, Yanguang Cao, Ji Jiang & Pei Hu
Pages: 1105-1111
Published online: 27 Jul 2016
AbstractforA unified strategy in selection of the best allometric scaling methods to predict human clearance based on drug disposition pathway | Full Text | References | PDF (1.5 MB) | Supplemental
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Article
Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres
Ronald Scott Obach, Erik A. LaChapelle, Michael A. Brodney, Michelle Vanase-Frawley, Gregory W. Kauffman & Aarti Sawant-Basak
Pages: 1112-1121
Published online: 07 Mar 2016
AbstractforStrategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres | Full Text | References | PDF (1.1 MB) | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Metabolite profiling of 14C-omacetaxine mepesuccinate in plasma and excreta of cancer patients
Cynthia M. Nijenhuis, Luc Lucas, Hilde Rosing, Philmore Robertson Jr, Edward T. Hellriegel, Jan H. M. Schellens & and Jos H. Beijnen
Pages: 1122-1132
Published online: 21 Mar 2016
AbstractforMetabolite profiling of 14C-omacetaxine mepesuccinate in plasma and excreta of cancer patients | Full Text | References | PDF (694 KB) | Supplemental
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Article
Pharmacokinetics and pharmacodynamics of intravenous ilaprazole in healthy subjects after single ascending doses
Hongyun Wang, Ning Ou, Liwei Lang, Ruihua Shi, Pei Hu & Ji Jiang
Pages: 1133-1141
Published online: 21 Mar 2016
AbstractforPharmacokinetics and pharmacodynamics of intravenous ilaprazole in healthy subjects after single ascending doses | Full Text | References | PDF (995.8 KB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration
Chun Wang, Jun Yuan, Ling Ling Zhang & Wei Wei
Pages: 1142-1150
Published online: 21 Mar 2016
AbstractforPharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration | Full Text | References | PDF (1.3 MB) | Supplemental
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Editorial Board

Editorial Board
Page: ebi
Published online: 03 Oct 2016
CitationforEditorial Board | Full Text | PDF (91.5 KB)
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