Xenobiotica, Volume 46, Issue 2 (2016)

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Xenobiotica, Volume 46, Issue 2 (2016)

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General Xenobiochemistry

Article
Characterization of midazolam metabolism in locusts: the role of a CYP3A4-like enzyme in the formation of 1′-OH and 4-OH midazolam
Line Rørbæk Olsen, Charlotte Gabel-Jensen, Sileshi Gizachew Wubshet, Kenneth Thermann Kongstad, Christian Janfelt, Lassina Badolo & Steen Honoré Hansen
Pages: 99-107
Published online: 24 Jul 2015
AbstractforCharacterization of midazolam metabolism in locusts: the role of a CYP3A4-like enzyme in the formation of 1′-OH and 4-OH midazolam | Full Text | References | PDF (857.6 KB) | Supplemental
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Article
Characterisation of liver-specific distribution of a novel 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonist, SKL-13784: comparison with GC-1
Naoki Takahashi & Tohru Izuchi
Pages: 108-116
Published online: 15 Jun 2015
AbstractforCharacterisation of liver-specific distribution of a novel 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonist, SKL-13784: comparison with GC-1 | Full Text | References | PDF (383.1 KB)
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Article
Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents
Vamshi K. Manda, Bharathi Avula, Amar G. Chittiboyina, Ikhlas A. Khan, Larry A. Walker & Shabana I. Khan
Pages: 117-125
Published online: 06 Aug 2015
AbstractforInhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents | Full Text | References | PDF (595.6 KB) | Supplemental
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Article
In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs
Eiko Suzuki, Daisuke Nakai, Hidenori Ikenaga, Keiichi Fusegawa, Ryoya Goda, Nobuhiro Kobayashi, Hiroshi Kuga & Takashi Izumi
Pages: 126-131
Published online: 15 Jun 2015
AbstractforIn vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs | Full Text | References | PDF (589.7 KB)
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Article
Metabolism of drugs and other xenobiotics in giant liver fluke (Fascioloides magna)
Lukáš Prchal, Ivan Vokřál, Martin Kašný, Lenka Rejšková, Markéta Zajíčková, Jiří Lamka, Lenka Skálová, Lenka Lecová & Barbora Szotáková
Pages: 132-140
Published online: 07 Jul 2015
AbstractforMetabolism of drugs and other xenobiotics in giant liver fluke (Fascioloides magna) | Full Text | References | PDF (378.6 KB)
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Article
Ephedra water decoction and cough tablets containing ephedra and liquorice induce CYP1A2 but not CYP2E1 hepatic enzymes in rats
Jingling Tang, Hongyu Ji, Jing Shi & Linhua Wu
Pages: 141-146
Published online: 07 Jul 2015
AbstractforEphedra water decoction and cough tablets containing ephedra and liquorice induce CYP1A2 but not CYP2E1 hepatic enzymes in rats | Full Text | References | PDF (322.3 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans
Gary David Bowers, Amanda Culp, Melinda J. Reese, Glenn Tabolt, Lee Moss, Stephen Piscitelli, Phuong Huynh, David Wagner, Susan L. Ford, Elizabeth P. Gould, Rennan Pan, Yu Lou, David A. Margolis & William R. Spreen
Pages: 147-162
Published online: 01 Jul 2015
AbstractforDisposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans | Full Text | References | PDF (643 KB)
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Animal pharmacokinetics and metabolism

Article
Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus)
Shotaro Uehara, Takashi Inoue, Masahiro Utoh, Akiko Toda, Makiko Shimizu, Yasuhiro Uno, Erika Sasaki & Hiroshi Yamazaki
Pages: 163-168
Published online: 26 Jun 2015
AbstractforSimultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus) | Full Text | References | PDF (228.3 KB)
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Article
Route of administration and formulation dependent pharmacokinetics of 17-hydroxyprogesterone caproate in rats
Imam H. Shaik, Jaime R. Bastian, Yang Zhao, Steve N. Caritis & Raman Venkataramanan
Pages: 169-174
Published online: 07 Jul 2015
AbstractforRoute of administration and formulation dependent pharmacokinetics of 17-hydroxyprogesterone caproate in rats | Full Text | References | PDF (167.5 KB)
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Xenobiotic transporters

Article
Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3
Liping Li, Siyuan Sun, Yayun Weng, Feifeng Song, Sisi Zhou, Mengru Bai, Hui Zhou, Su Zeng & Huidi Jiang
Pages: 175-183
Published online: 02 Jul 2015
AbstractforInteraction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3 | Full Text | References | PDF (853.2 KB)
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Topics in Xenobiochemistry

Sulphate absorption across biological membranes
Stephen C. Mitchell & Rosemary H. Waring
Pages: 184-191
Published online: 30 Jul 2015
AbstractforSulphate absorption across biological membranes | Full Text | References | PDF (169.7 KB)
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