Xenobiotica, Volume 46, Issue 3 (2016)

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Xenobiotica, Volume 46, Issue 3 (2016)

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General Xenobiochemistry

Article
Molecular cloning and functional analysis of minipig UDP-glucuronosyltransferase 1A6
Yuuka Miyake, Riho Hirose, Takashi Isobe & Nobumitsu Hanioka
Pages: 193-199
Published online: 01 Jul 2015
AbstractforMolecular cloning and functional analysis of minipig UDP-glucuronosyltransferase 1A6 | Full Text | References | PDF (334.6 KB)
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Article
Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons
Jenni Küblbeck, Vanessa Zancanella, Viktoria Prantner, Ferdinand Molnár, E. James Squires, Mauro Dacasto, Paavo Honkakoski & Mery Giantin
Pages: 200-210
Published online: 07 Jul 2015
AbstractforCharacterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons | Full Text | References | PDF (1.5 MB)
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Article
Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13
Tsutomu Shimada, Shigeo Takenaka, Norie Murayama, Valerie M. Kramlinger, Joo-Hwan Kim, Donghak Kim, Jiawang Liu, Maryam K. Foroozesh, Hiroshi Yamazaki, F. Peter Guengerich & Masayuki Komori
Pages: 211-224
Published online: 06 Aug 2015
AbstractforOxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13 | Full Text | References | PDF (3.1 MB)
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Article
Effect of quercetin against mixture of four organophosphate pesticides induced nephrotoxicity in rats
Sifan Li, Can Cao, Haidan Shi, Shuang Yang, Lei Qi, Xiujuan Zhao & Changhao Sun
Pages: 225-233
Published online: 30 Jul 2015
AbstractforEffect of quercetin against mixture of four organophosphate pesticides induced nephrotoxicity in rats | Full Text | References | PDF (1.2 MB)
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Article
Characterisation of artemisinin–chloroquinoline hybrids for potential metabolic liabilities
Roslyn Thelingwani, Carina Leandersson, Britta Bonn, Peter Smith, Kelly Chibale & Collen Masimirembwa
Pages: 234-240
Published online: 17 Aug 2015
AbstractforCharacterisation of artemisinin–chloroquinoline hybrids for potential metabolic liabilities | Full Text | References | PDF (364.8 KB)
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Article
Effect of buffer conditions on CYP2C8-mediated paclitaxel 6α-hydroxylation and CYP3A4-mediated triazolam α- and 4-hydroxylation by human liver microsomes
Toshiyuki Kudo, Yuya Ozaki, Tomomi Kusano, Eri Hotta, Yuka Oya, Seina Komatsu, Hitomi Goda & Kiyomi Ito
Pages: 241-246
Published online: 19 Aug 2015
AbstractforEffect of buffer conditions on CYP2C8-mediated paclitaxel 6α-hydroxylation and CYP3A4-mediated triazolam α- and 4-hydroxylation by human liver microsomes | Full Text | References | PDF (374.5 KB)
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Animal Pharmacokinetics and Metabolism

Article
Tissue distribution of pretomanid in rat brain via mass spectrometry imaging
Adeola Shobo, Dominika Bratkowska, Sooraj Baijnath, Suhashni Naiker, Anou M. Somboro, Linda A. Bester, Sanil D. Singh, Tricia Naicker, Hendrik G. Kruger & Thavendran Govender
Pages: 247-252
Published online: 24 Jul 2015
AbstractforTissue distribution of pretomanid in rat brain via mass spectrometry imaging | Full Text | References | PDF (772.6 KB)
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Article
The metabolism of the dual endothelin receptor antagonist macitentan in rat and dog
Alexander Treiber, Tommaso Miraval, Martin H. Bolli, Jacques-Alexis Funel, Jerome Segrestaa & Swen Seeland
Pages: 253-267
Published online: 17 Aug 2015
AbstractforThe metabolism of the dual endothelin receptor antagonist macitentan in rat and dog | Full Text | References | PDF (1,009.9 KB)
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Article
Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor
Nathalie Rioux, Kenneth W. Duncan, Ronald J. Lantz, Xiusheng Miao, Elayne Chan-Penebre, Mikel P. Moyer, Michael J. Munchhof, Robert A. Copeland, Richard Chesworth & Nigel J. Waters
Pages: 268-277
Published online: 31 Jul 2015
AbstractforSpecies differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor | Full Text | References | PDF (884.2 KB)
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Pharmacogenetics

Article
Impact of CYP2C8*3 polymorphism on in vitro metabolism of imatinib to N-desmethyl imatinib
Muhammad Suleman Khan, Daniel T. Barratt & Andrew A. Somogyi
Pages: 278-287
Published online: 10 Jul 2015
AbstractforImpact of CYP2C8*3 polymorphism on in vitro metabolism of imatinib to N-desmethyl imatinib | Full Text | References | PDF (482.9 KB)
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