Xenobiotica, Volume 46, Issue 5 (2016)

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Xenobiotica, Volume 46, Issue 5 (2016)

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General Xenobiochemistry

Article
Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study
Chiedza F. Munyeza, Adeola Shobo, Sooraj Baijnath, Dominika Bratkowska, Suhashni Naiker, Linda A. Bester, Sanil D. Singh, Glenn E. M. Maguire, Hendrik G. Kruger, Tricia Naicker & Thavendran Govender
Pages: 385-392
Published online: 31 Aug 2015
AbstractforRapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study | Full Text | References | PDF (1.2 MB)
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Article
Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells
Wei Shang, Jie Liu, Ruini Chen, Rui Ning, Jing Xiong, Wei Liu, Zhao Mao, Gang Hu & Jian Yang
Pages: 393-405
Published online: 04 Sep 2015
AbstractforFluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells | Full Text | References | PDF (1.1 MB)
  • 513 Views
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Article
Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomes
Joanna M. Redmon, Binu Shrestha, Rosario Cerundolo & Michael H. Court
Pages: 406-415
Published online: 14 Sep 2015
AbstractforSoy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomes | Full Text | References | PDF (755.9 KB)
  • 347 Views
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Article
Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs)
Jakub Hofman, Radim Kučera, Zuzana Neumanova, Jiri Klimes, Martina Ceckova & Frantisek Staud
Pages: 416-423
Published online: 12 Sep 2015
AbstractforPlacental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs) | Full Text | References | PDF (563.5 KB)
  • 216 Views
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Article
Effect of CYP2D6 variants on venlafaxine metabolism in vitro
Yun-Yun Zhan, Bing-Qing Liang, Hao Wang, Zhen-He Wang, Qing-Hua Weng, Da-Peng Dai, Jian-Ping Cai & Guo-Xin Hu
Pages: 424-429
Published online: 25 Sep 2015
AbstractforEffect of CYP2D6 variants on venlafaxine metabolism in vitro | Full Text | References | PDF (534.9 KB)
  • 452 Views
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Animal Pharmacokinetics and Metabolism

Article
Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat
Michael F. Hughes, David G. Ross, Brenda C. Edwards, Michael J. DeVito & James M. Starr
Pages: 430-438
Published online: 14 Sep 2015
AbstractforTissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat | Full Text | References | PDF (488.8 KB) | Supplemental
  • 279 Views
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Article
The effect of resveratrol on pharmacokinetics of aripiprazole in vivo and in vitro
Yun-Yun Zhan, Bing-Qing Liang, Xiang-Yu Li, Er-Min Gu, Da-Peng Dai, Jian-Ping Cai & Guo-Xin Hu
Pages: 439-444
Published online: 22 Sep 2015
AbstractforThe effect of resveratrol on pharmacokinetics of aripiprazole in vivo and in vitro | Full Text | References | PDF (422.5 KB)
  • 407 Views
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Xenobiotic Transporters

Article
Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam
Melinda J. Reese, Gary D. Bowers, Joan E. Humphreys, Elizabeth P. Gould, Susan L. Ford, Lindsey O. Webster & Joseph W. Polli
Pages: 445-456
Published online: 04 Sep 2015
AbstractforDrug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam | Full Text | References | PDF (331.2 KB) | Supplemental
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Article
Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III
Dallas Bednarczyk & Carri Boiselle
Pages: 457-466
Published online: 18 Sep 2015
AbstractforOrganic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III | Full Text | References | PDF (1 MB)
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Article
The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes
Xianbao Shi, Shuman Yang, Gang Zhang, Yonggui Song, Dan Su, Yali Liu, Feng Guo, Lina Shan & Jiqun Cai
Pages: 467-476
Published online: 15 Sep 2015
AbstractforThe different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes | Full Text | References | PDF (1.1 MB)
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