Xenobiotica, Volume 46, Issue 6 (2016)

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Xenobiotica, Volume 46, Issue 6 (2016)

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General Xenobiochemistry

Article
On the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central elimination
Leonid M. Berezhkovskiy
Pages: 477-482
Published online: 25 Sep 2015
AbstractforOn the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central elimination | Full Text | References | PDF (170 KB)
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Article
Shedding light on minipig drug metabolism – elevated amide hydrolysis in vitro
Russell Jones, Michaela Marschmann, Michael Keller, Na Hong Qiu, Stephen Fowler, Thomas Singer, Franz Schuler, Christoph Funk & Simone Schadt
Pages: 483-494
Published online: 25 Sep 2015
AbstractforShedding light on minipig drug metabolism – elevated amide hydrolysis in vitro | Full Text | References | PDF (880.4 KB)
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Article
In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans
Kazutaka Sekiguchi, Takushi Kanazu, Norie Murayama, Hiroshi Yamazaki & Yoshitaka Yamaguchi
Pages: 495-502
Published online: 18 Dec 2015
AbstractforIn vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans | Full Text | References | PDF (577.7 KB) | Supplemental
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Article
Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1)
Dong-Xue Sun, Guang-Bo Ge, Pei-Pei Dong, Yun-Feng Cao, Zhi-Wei Fu, Rui-Xue Ran, Xue Wu, Yan-Yan Zhang, Hui-Ming Hua, Zhenying Zhao & Zhong-Ze Fang
Pages: 503-510
Published online: 11 Nov 2015
AbstractforInhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1) | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Effects of chronic exposure to tributyltin on tissue-specific cytochrome P450 1 regulation in juvenile common carp
Zhi-Hua Li, Li-Qiao Zhong, Wei-Na Mu & Yan-Hua Wu
Pages: 511-515
Published online: 07 Oct 2015
AbstractforEffects of chronic exposure to tributyltin on tissue-specific cytochrome P450 1 regulation in juvenile common carp | Full Text | References | PDF (224.5 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Effect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet–drug interaction study
Jinqing Hu, Dewei Shang, Xinwen Xu, Xiuling He, Xiaojia Ni, Ming Zhang, Zhanzhang Wang, Chang Qiu, Shuhua Deng, Haoyang Lu, Xiuqing Zhu, Wencan Huang & Yuguan Wen
Pages: 516-521
Published online: 25 Sep 2015
AbstractforEffect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet–drug interaction study | Full Text | References | PDF (211.6 KB)
  • 655 Views
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics, pharmacokinetic–pharmacodynamic relationship, and withdrawal period of amoxicillin sodium in olive flounder (Paralichthys olivaceus)
Ji-Yong Park, Elias Gebru Awji, Joo-Won Suh & Seung-Chun Park
Pages: 522-529
Published online: 25 Sep 2015
AbstractforPharmacokinetics, pharmacokinetic–pharmacodynamic relationship, and withdrawal period of amoxicillin sodium in olive flounder (Paralichthys olivaceus) | Full Text | References | PDF (526 KB)
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Article
Pharmacokinetic and pharmacodynamic interactions of aspirin with warfarin in beagle dogs
Chenlin Shen, Xiaohui Huang, Jun Li, Ping Zhang, Lin Li, Wei Zhang, Tingting Hu, Faustina Pappoe, Jihan Huang & Haiqin Tang
Pages: 530-541
Published online: 07 Nov 2015
AbstractforPharmacokinetic and pharmacodynamic interactions of aspirin with warfarin in beagle dogs | Full Text | References | PDF (919.2 KB)
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Pharmacogenetics

Article
Genetic polymorphism analysis of the drug-metabolizing enzyme CYP1A2 in a Uyghur Chinese population: a pilot study
Tingting Geng, Xi yang Zhang, Li Wang, Huijuan Wang, Xugang Shi, Longli Kang, Peng Hou & Tianbo Jin
Pages: 542-547
Published online: 18 Sep 2015
AbstractforGenetic polymorphism analysis of the drug-metabolizing enzyme CYP1A2 in a Uyghur Chinese population: a pilot study | Full Text | References | PDF (359.5 KB)
  • 171 Views
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Xenobiotic Transporters

Article
ATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord
Zoe Riches, Gurinder Walia, Jacob M. Berman, Tricia E. Wright & Abby C. Collier
Pages: 548-556
Published online: 25 Sep 2015
AbstractforATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord | Full Text | References | PDF (848.1 KB)
  • 215 Views
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Topics in Xenobiochemistry (Review)

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound
Hidetaka Kamimura & Satoshi Ito
Pages: 557-569
Published online: 07 Oct 2015
AbstractforAssessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound | Full Text | References | PDF (1.3 MB)
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