Xenobiotica, Volume 46, Issue 9 (2016)

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Xenobiotica, Volume 46, Issue 9 (2016)

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General Xenobiochemistry

Article
Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling
Satomi Shida & Hiroshi Yamazaki
Pages: 759-764
Published online: 10 Dec 2015
AbstractforHuman plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling | Full Text | References | PDF (647.1 KB)
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Article
Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells
Ikuo Sugiyama, Norie Murayama, Ayaka Kuroki, Jagannath Kota, Shunsuke Iwano, Hiroshi Yamazaki & Takashi Hirota
Pages: 765-774
Published online: 29 Dec 2015
AbstractforEvaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells | Full Text | References | PDF (487.3 KB)
  • 592 Views
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Article
Absorption characteristic of paeoniflorin-6′-O-benzene sulfonate (CP-25) in in situ single-pass intestinal perfusion in rats
Xiao-Dan Yang, Chun Wang, Peng Zhou, Jun Yu, James Asenso, Yong Ma & Wei Wei
Pages: 775-783
Published online: 29 Dec 2015
AbstractforAbsorption characteristic of paeoniflorin-6′-O-benzene sulfonate (CP-25) in in situ single-pass intestinal perfusion in rats | Full Text | References | PDF (816.3 KB) | Supplemental
  • 211 Views
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Article
Interspecies scaling of excretory amounts using allometry – retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion
Nuggehally R. Srinivas
Pages: 784-792
Published online: 29 Dec 2015
AbstractforInterspecies scaling of excretory amounts using allometry – retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion | Full Text | References | PDF (508.1 KB)
  • 316 Views
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS
Jing An, Fangdi Hu, Changhong Wang, Zijia Zhang, Li Yang & Zhengtao Wang
Pages: 793-804
Published online: 10 Jan 2016
AbstractforPharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS | Full Text | References | PDF (1.7 MB)
  • 233 Views
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Molecular Toxicology

Article
Metabonomic analysis of quercetin against the toxicity of chronic exposure to a mixture of four organophosphate pesticides in rat plasma
Can Cao, Yan Zeng, Haidan Shi, Shuang Yang, Wei Bao, Lei Qi, Ying Liu & Xiujun Zhao
Pages: 805-815
Published online: 17 Dec 2015
AbstractforMetabonomic analysis of quercetin against the toxicity of chronic exposure to a mixture of four organophosphate pesticides in rat plasma | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
Gambogic acid potentiates clopidogrel-induced apoptosis and attenuates irinotecan-induced apoptosis through down-regulating human carboxylesterase 1 and -2
Rui Ning, Xiao-Ping Wang, Yun-Ran Zhan, Qi Qi, Xue-Feng Huang, Gang Hu, Qing-Long Guo, Wei Liu & Jian Yang
Pages: 816-824
Published online: 10 Jan 2016
AbstractforGambogic acid potentiates clopidogrel-induced apoptosis and attenuates irinotecan-induced apoptosis through down-regulating human carboxylesterase 1 and -2 | Full Text | References | PDF (2 MB)
  • 238 Views
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Xenobiotic Transporters

Article
Inverse association between microRNA-124a and ABCC4 in HepG2 cells treated with antiretroviral drugs
Savania Nagiah, Alisa Phulukdaree & Anil Chuturgoon
Pages: 825-830
Published online: 08 Dec 2015
AbstractforInverse association between microRNA-124a and ABCC4 in HepG2 cells treated with antiretroviral drugs | Full Text | References | PDF (373.4 KB)
  • 144 Views
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Article
The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs)
Jian Zheng, Ting Chan, Ling Zhu, Xiufeng Yan, Zhisong Cao, Yang Wang & Fanfan Zhou
Pages: 831-840
Published online: 08 Jan 2016
AbstractforThe inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs) | Full Text | References | PDF (1.1 MB)
  • 316 Views
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Article
Mixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers
Xue-Feng Lu, Yang Zhou, Kai-Shun Bi & Xiao-Hui Chen
Pages: 841-849
Published online: 08 Jan 2016
AbstractforMixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers | Full Text | References | PDF (510.6 KB) | Supplemental
  • 507 Views
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Pharmacogenetics

Article
Genetic polymorphisms of the drug-metabolizing enzyme cytochrome P450 3A5 in a Uyghur Chinese population
Zhengshuai Chen, Jingjie Li, Peng Chen, Fengjiao Wang, Ning Zhang, Min Yang, Tianbo Jin & Chao Chen
Pages: 850-856
Published online: 07 Jan 2016
AbstractforGenetic polymorphisms of the drug-metabolizing enzyme cytochrome P450 3A5 in a Uyghur Chinese population | Full Text | References | PDF (650.3 KB)
  • 129 Views
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