Xenobiotica, Volume 47, Issue 10 (2017)

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Xenobiotica, Volume 47, Issue 10 (2017)

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General Xenobiochemistry

Article
Gene expression study of phase I and II metabolizing enzymes in RPTEC/TERT1 cell line: application in in vitro nephrotoxicity prediction
Heta Shah, Manish Patel & Neeta Shrivastava
Pages: 837-843
Published online: 03 Oct 2016
AbstractforGene expression study of phase I and II metabolizing enzymes in RPTEC/TERT1 cell line: application in in vitro nephrotoxicity prediction | Full Text | References | PDF (472.3 KB)
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Article
Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice
Makiko Shimizu, Hiroshi Suemizu, Marina Mitsui, Norio Shibata, F. Peter Guengerich & Hiroshi Yamazaki
Pages: 844-848
Published online: 16 Nov 2016
AbstractforMetabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice | Full Text | References | PDF (692.6 KB)
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Article
Inhibitory effects of curculigoside on human liver cytochrome P450 enzymes
Jixiao Lang, Wei Li, Jingming Zhao, Kaiyou Wang & Dexi Chen
Pages: 849-855
Published online: 03 Jul 2017
AbstractforInhibitory effects of curculigoside on human liver cytochrome P450 enzymes | Full Text | References | PDF (692.5 KB)
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Clinical Pharmacokinetics and Metabolism

Article
An open-label, single-dose, phase 1 study of the absorption, metabolism and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia
Madhu Sanga, Joyce James, Joseph Marini, Guy Gammon, Christine Hale & Jianke Li
Pages: 856-869
Published online: 25 Jul 2017
AbstractforAn open-label, single-dose, phase 1 study of the absorption, metabolism and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia | Full Text | References | PDF (884.4 KB)
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Article
Pharmacokinetics of guaifenesin, pseudoephedrine and hydrocodone in a combination oral liquid formulation, administered as single and multiple doses in healthy Chinese volunteers, and comparison with data for individual compounds formulated as Antuss®
Shuhua Deng, Wencan Huang, Xiaojia Ni, Ming Zhang, Haoyang Lu, Zhanzhang Wang, Jinqing Hu, Xiuqing Zhu, Chang Qiu, Dewei Shang, Yuefeng Zhang, Linghui Xiong & Yuguan Wen
Pages: 870-878
Published online: 24 Oct 2016
AbstractforPharmacokinetics of guaifenesin, pseudoephedrine and hydrocodone in a combination oral liquid formulation, administered as single and multiple doses in healthy Chinese volunteers, and comparison with data for individual compounds formulated as Antuss® | Full Text | References | PDF (487.8 KB)
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Article
Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects
Satish Kumar Bedada & Praveen Kumar Boga
Pages: 879-884
Published online: 28 Oct 2016
AbstractforInfluence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects | Full Text | References | PDF (433.4 KB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetic characterization of anhuienoside C and its deglycosylated metabolites in rats
Hua Sun, Hui Liu, Huinan Zhao, Ying Wang, Yao-lan Li, Wen-cai Ye & Baojian Wu
Pages: 885-893
Published online: 24 Oct 2016
AbstractforPharmacokinetic characterization of anhuienoside C and its deglycosylated metabolites in rats | Full Text | References | PDF (660.4 KB)
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Article
The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration
Gabriel A. Knudsen, J. Michael Sanders, Michael F. Hughes, Ethan P. Hull & Linda S. Birnbaum
Pages: 894-902
Published online: 28 Oct 2016
AbstractforThe biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration | Full Text | References | PDF (476.3 KB)
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Xenobiotic Transporters

Article
In vitro assessment of the roles of drug transporters in the disposition and drug–drug interaction potential of olaparib
Alex McCormick & Helen Swaisland
Pages: 903-915
Published online: 26 Oct 2016
AbstractforIn vitro assessment of the roles of drug transporters in the disposition and drug–drug interaction potential of olaparib | Full Text | References | PDF (475.5 KB)
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Pharmacogenetics

Article
Effect of hepatic drug transporter polymorphisms on the pharmacokinetics of mycophenolic acid in patients with severe renal dysfunction before renal transplantation
Hideaki Kagaya, Takenori Niioka, Mitsuru Saito, Takamitsu Inoue, Kazuyuki Numakura, Tomonori Habuchi, Shigeru Satoh & Masatomo Miura
Pages: 916-922
Published online: 24 Oct 2016
AbstractforEffect of hepatic drug transporter polymorphisms on the pharmacokinetics of mycophenolic acid in patients with severe renal dysfunction before renal transplantation | Full Text | References | PDF (240.8 KB)
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Topics in Xenobiochemistry

Review
Cytochrome P450 2W1 (CYP2W1) – ready for use as the biomarker and drug target for cancer?
Yan Pan & Eng Chin Ong
Pages: 923-932
Published online: 24 Oct 2016
AbstractforCytochrome P450 2W1 (CYP2W1) – ready for use as the biomarker and drug target for cancer? | Full Text | References | PDF (451 KB)
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