Xenobiotica, Volume 47, Issue 12 (2017)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 47, Issue 12 (2017)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Volume 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker
Hitomi Yamasaki, Naohiro Kawaguchi, Masami Nonaka, Junzo Takahashi, Akio Morohashi, Hideki Hirabayashi, Toshiya Moriwaki & Satoru Asahi
Pages: 1027-1034
Published online: 14 Jul 2016
AbstractforIn vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker | Full Text | References | PDF (275.2 KB)
  • 852 Views
  • 43 CrossRef citations
  • 0Altmetric
Article
Effect of piperine on CYP2E1 enzyme activity of chlorzoxazone in healthy volunteers
Satish Kumar Bedada & Praveen Kumar Boga
Pages: 1035-1041
Published online: 16 Nov 2016
AbstractforEffect of piperine on CYP2E1 enzyme activity of chlorzoxazone in healthy volunteers | Full Text | References | PDF (510.7 KB)
  • 232 Views
  • 14 CrossRef citations
  • 0Altmetric
Article
Preclinical evaluation of the potential for cytochrome P450 inhibition and induction of the selective ALK inhibitor, alectinib
Nobuo Sekiguchi, Shunsuke Nagao, Kenji Takanashi, Motohiro Kato, Akihisa Kaneko, Keiichi Morita, Hidetoshi Shindoh & Masaki Ishigai
Pages: 1042-1051
Published online: 01 Dec 2016
AbstractforPreclinical evaluation of the potential for cytochrome P450 inhibition and induction of the selective ALK inhibitor, alectinib | Full Text | References | PDF (465.9 KB)
  • 598 Views
  • 8 CrossRef citations
  • 0Altmetric
Article
Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver
Maki Miyamoto, Shinji Iwasaki, Ikumi Chisaki, Sayaka Nakagawa, Nobuyuki Amano & Hideki Hirabayashi
Pages: 1052-1063
Published online: 02 Mar 2017
AbstractforComparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver | Full Text | References | PDF (372 KB)
  • 1915 Views
  • 37 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration
Justine L. Lam, Alfin Vaz, Brian Hee, Yali Liang, Xin Yang & M. Naveed Shaik
Pages: 1064-1076
Published online: 03 Jan 2017
AbstractforMetabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration | Full Text | References | PDF (1.2 MB)
  • 509 Views
  • 21 CrossRef citations
  • 0Altmetric
Article
Pradigastat disposition in humans: in vivo and in vitro investigations
Alana Upthagrove, Jin Chen, Charles D. Meyers, Kenneth Kulmatycki, Angela Bretz, Lai Wang, Lana Peng, Safet Palamar, Melissa Lin, Tapan Majumdar, Phi Tran & Heidi J. Einolf
Pages: 1077-1089
Published online: 12 Dec 2016
AbstractforPradigastat disposition in humans: in vivo and in vitro investigations | Full Text | References | PDF (455.6 KB)
  • 350 Views
  • 4 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys
Makiko Yamada, Makoto Takei, Eiko Suzuki, Hideo Takakusa, Masakatsu Kotsuma, Takuo Washio, Nobuyuki Murayama, Shin-ichi Inoue & Takashi Izumi
Pages: 1090-1103
Published online: 12 Dec 2016
AbstractforPharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys | Full Text | References | PDF (895.4 KB)
  • 539 Views
  • 28 CrossRef citations
  • 0Altmetric
Article
Oral pharmacokinetic interaction of ester rich fruit juices and pharmaceutical excipients with tenofovir disoproxil fumarate in male Wistar rats
Joseph Shailender, Punna Rao Ravi, Paramita Saha & Srividya Myneni
Pages: 1104-1111
Published online: 12 Jan 2017
AbstractforOral pharmacokinetic interaction of ester rich fruit juices and pharmaceutical excipients with tenofovir disoproxil fumarate in male Wistar rats | Full Text | References | PDF (443.8 KB) | Supplemental
  • 301 Views
  • 4 CrossRef citations
  • 0Altmetric

Xenobiotic transporters

Article
Potent inhibition of human organic cation transporter 2 (hOCT2) by β-carboline alkaloids
David J. Wagner, Haichuan Duan, Alenka Chapron, Richard W. Lee & Joanne Wang
Pages: 1112-1120
Published online: 02 Mar 2017
AbstractforPotent inhibition of human organic cation transporter 2 (hOCT2) by β-carboline alkaloids | Full Text | References | PDF (733.8 KB)
  • 284 Views
  • 4 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Effects of cytochrome P450 3A4 and non-genetic factors on initial voriconazole serum trough concentrations in hematological patients with different cytochrome P450 2C19 genotypes
Beibei Shao, Yongcheng Ma, Qiaoyan Li, Yimeng Wang, Zunmin Zhu, Hongwei Zhao, Jun Sun, Lingfang Dong, Yingli Zhu, Ningmin Zhao & Yuhua Qin
Pages: 1121-1129
Published online: 03 Jan 2017
AbstractforEffects of cytochrome P450 3A4 and non-genetic factors on initial voriconazole serum trough concentrations in hematological patients with different cytochrome P450 2C19 genotypes | Full Text | References | PDF (329.6 KB)
  • 295 Views
  • 17 CrossRef citations
  • 0Altmetric
Article
Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers
Mupeng Li, Yaodong Hu, Zhipeng Wen, Huilan Li, Xiaolei Hu, Yanjiao Zhang, Zanling Zhang, Jian Xiao, Jie Tang & Xiaoping Chen
Pages: 1130-1138
Published online: 12 Jan 2017
AbstractforAssociation of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers | Full Text | References | PDF (515.1 KB)
  • 329 Views
  • 16 CrossRef citations
  • 0Altmetric

Editorial Board

Editorial Board
Page: ebi
Published online: 19 Oct 2017
CitationforEditorial Board | Full Text | PDF (23.4 KB)
  • 26 Views
  • 0 CrossRef citations
  • 0Altmetric

Explore articles

Explore the most recently published articles

Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Michael Z. Liao et al.
Review Article | Published online: 13 May 2024
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers
Meghan E. Gray et al.
Article | Published online: 13 May 2024
Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs
Qihong Huang et al.
Review Article | Published online: 11 May 2024
Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?
Maria Luisa Sardu et al.
Review Article | Published online: 30 Apr 2024
View all latest articles