Xenobiotica, Volume 47, Issue 1 (2017)

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Xenobiotica, Volume 47, Issue 1 (2017)

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General Xenobiochemistry

Article
Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms
Christina M. Street, Zhaohui Zhu, Moshe Finel & Michael H. Court
Pages: 1-10
Published online: 21 Mar 2016
AbstractforBisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms | Full Text | References | PDF (665.5 KB)
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Article
In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes
Pei Yu, Hongcong Qiu, Min Wang, Yuan Tian, Zunjian Zhang & Rui Song
Pages: 11-19
Published online: 06 Apr 2016
AbstractforIn vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes | Full Text | References | PDF (1.4 MB)
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Animal Pharmacokinetics and Metabolism

Article
Differential effects of pravastatin on the pharmacokinetics of paroxetine in normal and diabetic rats
Feng Li, Zhao-li Ling, Zhong-jian Wang, Ze-yu Zhong, Nan Shu, Mian Zhang, Can Liu, Li Liu & Xiao-dong Liu
Pages: 20-30
Published online: 05 May 2016
AbstractforDifferential effects of pravastatin on the pharmacokinetics of paroxetine in normal and diabetic rats | Full Text | References | PDF (877.6 KB)
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Article
Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents
Jian Guo, Camil Joubran, Ricardo A. Luzietti Jr., Gregory S. Basarab, Scott W. Grimm & Karthick Vishwanathan
Pages: 31-49
Published online: 28 Apr 2016
AbstractforAbsorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents | Full Text | References | PDF (1.8 MB)
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Article
Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs
Ryan H. Takahashi, Shuguang Ma, Qin Yue, Heasook Kim-Kang, Yijun Yi, Justin Ly, Jason W. Boggs, Alec Fettes, Andrew McClory, Yuzhong Deng, Cornelis E. C. A. Hop, S. Cyrus Khojasteh & Edna F. Choo
Pages: 50-65
Published online: 08 Apr 2016
AbstractforAbsorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs | Full Text | References | PDF (2.9 MB)
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Article
Insight into the pharmacokinetic behavior of tanshinone IIA in the treatment of Crohn’s disease: comparative data for tanshinone IIA and its two glucuronidated metabolites in normal and recurrent colitis models after oral administration
Qiong Wang, Chao Jiang, Xiao Zheng, Xuanxuan Zhu, Shihai Yan, Haidan Wang, Rui Fu, Hongwei Fan & Yugen Chen
Pages: 66-76
Published online: 04 Apr 2016
AbstractforInsight into the pharmacokinetic behavior of tanshinone IIA in the treatment of Crohn’s disease: comparative data for tanshinone IIA and its two glucuronidated metabolites in normal and recurrent colitis models after oral administration | Full Text | References | PDF (1.3 MB)
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Xenobiotic Transporters

Article
Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters
Josef Reznicek, Martina Ceckova, Lukas Cerveny, Fabian Müller & Frantisek Staud
Pages: 77-85
Published online: 06 Apr 2016
AbstractforEmtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters | Full Text | References | PDF (912.2 KB)
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Article
Epigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in rats
Wei Yang, Qiuyang Zhang, Yue Yang, Jiaqiu Xu, Ali Fan, Chung S. Yang, Ning Li, Yang Lu, Jiayin Chen, Di Zhao, Jiye Aa & Xijing Chen
Pages: 86-92
Published online: 06 Apr 2016
AbstractforEpigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in rats | Full Text | References | PDF (561.4 KB)
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