Xenobiotica, Volume 47, Issue 2 (2017)

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Xenobiotica, Volume 47, Issue 2 (2017)

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General Xenobiochemistry

Article
Characterization of feline cytochrome P450 2B6
Gaku Okamatsu, Tetsuya Komatsu, Yuka Ono, Hiroki Inoue, Tsuyoshi Uchide, Takenori Onaga, Daiji Endoh, Takio Kitazawa, Takeo Hiraga, Yasuhiro Uno & Hiroki Teraoka
Pages: 93-102
Published online: 09 Mar 2016
AbstractforCharacterization of feline cytochrome P450 2B6 | Full Text | References | PDF (585.2 KB)
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Article
Oxidative bioactivation of nitrofurantoin in rat liver microsomes
Hui Li, Dongju Lin, Ying Peng & Jiang Zheng
Pages: 103-111
Published online: 19 Apr 2016
AbstractforOxidative bioactivation of nitrofurantoin in rat liver microsomes | Full Text | References | PDF (701.8 KB)
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Article
Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures – accurate prediction of the human urinary excretory amounts
Ravi Kanth Bhamidipati, Ramesh Mullangi & Nuggehally R. Srinivas
Pages: 112-118
Published online: 19 Apr 2016
AbstractforInterspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures – accurate prediction of the human urinary excretory amounts | Full Text | References | PDF (231.7 KB)
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Article
Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy
Aarti Sawant-Basak, Laigao Chen, Christopher L. Shaffer, Donna Palumbo, Anne Schmidt, Elaine Tseng, Douglas K. Spracklin, Jean-Dominique Gallezot, David Labaree, Nabeel Nabulsi, Yiyun Huang, Richard E. Carson & Timothy McCarthy
Pages: 119-126
Published online: 29 Jun 2016
AbstractforQuantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy | Full Text | References | PDF (516.5 KB) | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Study on influence of piperine treatment on the pharmacokinetics of diclofenac in healthy volunteers
Satish Kumar Bedada, Praveen Kumar Boga & Harish Kaushik Kotakonda
Pages: 127-132
Published online: 06 Apr 2016
AbstractforStudy on influence of piperine treatment on the pharmacokinetics of diclofenac in healthy volunteers | Full Text | References | PDF (338.1 KB)
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Article
Evaluation of pharmacokinetic interactions between long-acting HIV-1 fusion inhibitor albuvirtide and lopinavir/ritonavir, in HIV-infected subjects, combined with clinical study and simulation results
Wanqiu Yang, Qingqing Xiao, Dan Wang, Cheng Yao & Jin Yang
Pages: 133-143
Published online: 06 Apr 2016
AbstractforEvaluation of pharmacokinetic interactions between long-acting HIV-1 fusion inhibitor albuvirtide and lopinavir/ritonavir, in HIV-infected subjects, combined with clinical study and simulation results | Full Text | References | PDF (961.3 KB)
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Article
A double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [13C6]-labeled basimglurant in humans
Elena Guerini, Simone Schadt, Gerard Greig, Ruth Haas, Christophe Husser, Manfred Zell, Christoph Funk, Thomas Hartung, Andreas Gloge & Navita L. Mallalieu
Pages: 144-153
Published online: 28 Apr 2016
AbstractforA double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [13C6]-labeled basimglurant in humans | Full Text | References | PDF (744 KB) | Supplemental
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Molecular Toxicology

Article
Involvement of protoporphyrin IX accumulation in the pathogenesis of isoniazid/rifampicin-induced liver injury: the prevention of curcumin
Leiyan He, Yaoxue Guo, Ye Deng, Chun Li, Chengzi Zuo & Wenxing Peng
Pages: 154-163
Published online: 24 Jan 2017
AbstractforInvolvement of protoporphyrin IX accumulation in the pathogenesis of isoniazid/rifampicin-induced liver injury: the prevention of curcumin | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?
Valerie Walker, Graham A. Mills, Mary E. Anderson, Brandall L. Ingle, John M. Jackson, Charlotte L. Moss, Hayley Sharrod-Cole & Paul J. Skipp
Pages: 164-175
Published online: 18 Apr 2016
AbstractforThe acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis? | Full Text | References | PDF (1.2 MB)
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Xenobiotic Transporters

Article
Saikosaponin A, an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cells and HepG2/ADM cells
Rui-Ping Ye & Zhen-Dong Chen
Pages: 176-184
Published online: 28 Apr 2016
AbstractforSaikosaponin A, an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cells and HepG2/ADM cells | Full Text | References | PDF (2.2 MB)
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