Xenobiotica, Volume 47, Issue 4 (2017)

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Xenobiotica, Volume 47, Issue 4 (2017)

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General Xenobiochemistry

Article
In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes
Dong Dong, Tianpeng Zhang, Danyi Lu, Jie Liu & Baojian Wu
Pages: 277-283
Published online: 16 May 2016
AbstractforIn vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes | Full Text | References | PDF (350.2 KB)
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Article
A microbial model of mammalian metabolism: biotransformation of 4,5-dimethoxyl-canthin-6-one using Cunninghamella blakesleeana CGMCC 3.970
Hong-Xia Fan, Zheng-Qun Zhou, Jun Peng, Bao-Jian Wu, He-Ru Chen, Xue-Feng Bao, Zhen-Qiang Mu, Wei-Hua Jiao, Xin-Sheng Yao & Hao Gao
Pages: 284-289
Published online: 30 May 2016
AbstractforA microbial model of mammalian metabolism: biotransformation of 4,5-dimethoxyl-canthin-6-one using Cunninghamella blakesleeana CGMCC 3.970 | Full Text | References | PDF (370.7 KB) | Supplemental
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Article
Multiple effects of magnesium isoglycyrrhizinate on the disposition of docetaxel in docetaxel-induced liver injury
Biao Qu, Rong Xing, Hong Wang, Xin Chen, Qin Ge, Daiyin Peng & Guangji Wang
Pages: 290-296
Published online: 24 May 2016
AbstractforMultiple effects of magnesium isoglycyrrhizinate on the disposition of docetaxel in docetaxel-induced liver injury | Full Text | References | PDF (473.7 KB)
  • 254 Views
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Article
Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro
Yanwen Cheng, Xiaoling Liang, Liying Feng, Duo Liu, Mengnan Qin, Shuang Liu, Gaofeng Liu & Mei Dong
Pages: 297-303
Published online: 16 Jun 2016
AbstractforEffects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro | Full Text | References | PDF (396.8 KB)
  • 260 Views
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Article
Structure- and isoform-specific glucuronidation of six curcumin analogs
Danyi Lu, Hui Liu, Wencai Ye, Ying Wang & Baojian Wu
Pages: 304-313
Published online: 20 Jun 2016
AbstractforStructure- and isoform-specific glucuronidation of six curcumin analogs | Full Text | References | PDF (1.4 MB) | Supplemental
  • 190 Views
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Article
In vitro evaluation of potential drug interactions mediated by cytochrome P450 and transporters for luseogliflozin, an SGLT2 inhibitor
Yukihiro Chino, Masatoshi Hasegawa, Yoshiki Fukasawa, Yoko Mano, Kagumi Bando, Atsunori Miyata, Yasuhiro Nakai, Hiromi Endo & Jun-ichi Yamaguchi
Pages: 314-323
Published online: 20 Jun 2016
AbstractforIn vitro evaluation of potential drug interactions mediated by cytochrome P450 and transporters for luseogliflozin, an SGLT2 inhibitor | Full Text | References | PDF (673.5 KB)
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Article
Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities
Michaela Kopečná-Zapletalová, Kristýna Krasulová, Pavel Anzenbacher, Petr Hodek & Eva Anzenbacherová
Pages: 324-331
Published online: 17 Jun 2016
AbstractforInteraction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities | Full Text | References | PDF (1.3 MB)
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Clinical Pharmacokinetics and Metabolism

Article
Metabolite profiling and enzyme reaction phenotyping of luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, in humans
Atsunori Miyata, Masatoshi Hasegawa, Kenji Hachiuma, Haruyuki Mori, Nobuko Horiuchi, Akiko Mizuno-Yasuhira, Yukihiro Chino, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa, Yasuhiro Nakai & Jun-ichi Yamaguchi
Pages: 332-345
Published online: 27 Jun 2016
AbstractforMetabolite profiling and enzyme reaction phenotyping of luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, in humans | Full Text | References | PDF (863.6 KB)
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Xenobiotic Transporters

Article
Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine
Fanuel T. Hagos, Monica J. Daood, Jacob A. Ocque, Thomas D. Nolin, Hulya Bayir, Samuel M. Poloyac, Patrick M. Kochanek, Robert S. B. Clark & Philip E. Empey
Pages: 346-353
Published online: 09 Jun 2016
AbstractforProbenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine | Full Text | References | PDF (543.7 KB)
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Topics in Xenobiochemistry

Review
Clinical pharmacokinetics of panobinostat, a novel histone deacetylase (HDAC) inhibitor: review and perspectives
Nuggehally R. Srinivas
Pages: 354-368
Published online: 25 May 2016
AbstractforClinical pharmacokinetics of panobinostat, a novel histone deacetylase (HDAC) inhibitor: review and perspectives | Full Text | References | PDF (320.7 KB)
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