Xenobiotica, Volume 47, Issue 6 (2017)

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Xenobiotica, Volume 47, Issue 6 (2017)

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General Xenobiochemistry

Article
In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes
Matthew Y. Bendikov, John O. Miners, Bradley S. Simpson, David J. Elliot, Susan J. Semple, David J. Claudie, Ross A. McKinnon, Elizabeth M. J. Gillam & Matthew J. Sykes
Pages: 461-469
Published online: 14 Jul 2016
AbstractforIn vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes | Full Text | References | PDF (475.5 KB)
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Article
Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human
Zuzana E. Haarhoff, Melissa A. Kramer, Tatyana A. Zvyaga, Jun Zhang, Priyadeep Bhutani, Murali Subramanian & A. David Rodrigues
Pages: 470-478
Published online: 08 Aug 2016
AbstractforComprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human | Full Text | References | PDF (805.3 KB) | Supplemental
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Article
Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography–tandem mass spectrometry
Xin Wang, Mei Zheng, Jia Liu, Zhou Qiao, Wenyuan Liu & Feng Feng
Pages: 479-487
Published online: 07 Jul 2016
AbstractforStereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography–tandem mass spectrometry | Full Text | References | PDF (667.1 KB)
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Article
Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug–drug interactions in rat liver
Shinji Iwasaki, Hideki Hirabayashi, Miyuki Funami & Nobuyuki Amano
Pages: 488-497
Published online: 20 Jul 2016
AbstractforUnbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug–drug interactions in rat liver | Full Text | References | PDF (630.1 KB)
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Article
Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites
Si-Cheng Liang, Guang-Bo Ge, Yang-Liu Xia, Dong Pei-Pei, Wang Ping, Xiao-Yi Qi, Tu Cai-Xia & Yang Ling
Pages: 498-504
Published online: 20 Jul 2016
AbstractforInhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites | Full Text | References | PDF (611 KB)
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Animal Pharmacokinetics and Metabolism

Article
Study on the metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites
Monika Židková, Igor Linhart, Marie Balíková, Michal Himl, Lubomír Váňa, Michal Vetýška, Tomáš Páleníček, Eva Lhotková & Martin Dušek
Pages: 505-514
Published online: 12 Jul 2016
AbstractforStudy on the metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites | Full Text | References | PDF (450.8 KB)
  • 278 Views
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Article
A conscious rat model involving bradycardia and hypotension after oral administration: a toxicokinetical study of aconitine
Panpan Zhang, Dezhi Kong, Qian Du, Jing Zhao, Qing Li, Jianghua Zhang, Tonghui Li & Leiming Ren
Pages: 515-525
Published online: 14 Jul 2016
AbstractforA conscious rat model involving bradycardia and hypotension after oral administration: a toxicokinetical study of aconitine | Full Text | References | PDF (743.7 KB)
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Article
Pharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats
Peng-Kai Ma, Bao-Hong Wei, Yan-Ling Cao, Qing Miao, Ning Chen, Chang-E Guo, Hong-Ying Chen & Yu-Jie Zhang
Pages: 526-537
Published online: 14 Jul 2016
AbstractforPharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats | Full Text | References | PDF (2.1 MB)
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Article
Lumiracoxib metabolism in male C57bl/6J mice: characterisation of novel in vivo metabolites
Anthony P. Dickie, Claire E. Wilson, Kay Schreiter, Roland Wehr, Ian D. Wilson & Rob Riley
Pages: 538-546
Published online: 18 Jul 2016
AbstractforLumiracoxib metabolism in male C57bl/6J mice: characterisation of novel in vivo metabolites | Full Text | References | PDF (360.7 KB) | Supplemental
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Molecular Toxicology

Article
Disturbance of zinc and glucose homeostasis by methyl tert-butyl ether (MTBE); evidence for type 2 diabetes
Arastoo Saeedi, Reza Fardid, Mohammad Javad Khoshnoud, Elaheh Kazemi, Mahmoud Omidi & Afshin Mohammadi-Bardbori
Pages: 547-552
Published online: 07 Jul 2016
AbstractforDisturbance of zinc and glucose homeostasis by methyl tert-butyl ether (MTBE); evidence for type 2 diabetes | Full Text | References | PDF (440.4 KB)
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Corrigendum

Correction
Correction to: Study on the metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites
Page: x
Published online: 20 Apr 2017
CitationforCorrection to: Study on the metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites | Full Text | PDF (112.7 KB)
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