Xenobiotica, Volume 47, Issue 7 (2017)

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Xenobiotica, Volume 47, Issue 7 (2017)

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General Xenobiochemistry

Article
Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues
Shotaro Uehara, Yasuhiro Uno, Sakura Ishii, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki
Pages: 553-561
Published online: 20 Jul 2016
AbstractforMarmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues | Full Text | References | PDF (317.9 KB)
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Article
Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model
Yannick Parmentier, Corinne Pothier, Audrey Delmas, Fabrice Caradec, Marie-Michèle Trancart, Fabrice Guillet, Belkacem Bouaita, Christophe Chesne, J. Brian Houston & Bernard Walther
Pages: 562-575
Published online: 03 Aug 2016
AbstractforDirect and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model | Full Text | References | PDF (511 KB)
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Open Access
Article
Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines
Zhiyuan Qin, Lei Zhao, Haihong Hu, Huidi Jiang, Lushan Yu & Su Zeng
Pages: 576-583
Published online: 02 Aug 2016
AbstractforUtilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines | Full Text | References | PDF (511.2 KB)
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Article
Oxidative metabolism of koumine is mainly catalyzed by microsomal CYP3A4/3A5
Yanxian Hu, Zhaoyu Wang, Xin Huang, Bijun Xia, Lan Tang, Zhijie Zheng & Ling Ye
Pages: 584-591
Published online: 08 Aug 2016
AbstractforOxidative metabolism of koumine is mainly catalyzed by microsomal CYP3A4/3A5 | Full Text | References | PDF (1.1 MB)
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Clinical Pharmacokinetics and Metabolism

Article
A single-dose study investigating the pharmacokinetics and pharmacodynamics of edoxaban at 30–90 mg in healthy Chinese volunteers
Xia Chen, Dongyang Liu, Yiwen Wu, Hanlin Song, Yang Liu, Ji Jiang & Pei Hu
Pages: 592-599
Published online: 25 Aug 2016
AbstractforA single-dose study investigating the pharmacokinetics and pharmacodynamics of edoxaban at 30–90 mg in healthy Chinese volunteers | Full Text | References | PDF (612.7 KB)
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Animal Pharmacokinetics and Metabolism

Article
Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies
Mary E. Spilker, Heekyung Chung, Ravi Visswanathan, Shubha Bagrodia, Steven Gernhardt, Valeria R. Fantin & Lesley G. Ellies
Pages: 600-606
Published online: 20 Jul 2016
AbstractforLeveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies | Full Text | References | PDF (454.4 KB)
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Article
Investigation of the influence of glycyrrhizin on the pharmacokinetics of celastrol in rats using LC-MS and its potential mechanism
Guangkui Yan, Hanhua Zhang, Wei Wang, Yuan Li, Chenghuang Mao, Mingqiao Fang, Xianhong Yi & Jingdong Zhang
Pages: 607-613
Published online: 05 Dec 2016
AbstractforInvestigation of the influence of glycyrrhizin on the pharmacokinetics of celastrol in rats using LC-MS and its potential mechanism | Full Text | References | PDF (436.3 KB)
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Xenobiotic Transporters

Article
Effect of OATP-binding on the prediction of biliary excretion
Mohsen Sharifi & Taravat Ghafourian
Pages: 614-631
Published online: 02 Aug 2016
AbstractforEffect of OATP-binding on the prediction of biliary excretion | Full Text | References | PDF (2 MB) | Supplemental
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Topics in Xenobiochemistry

Review
Nanomaterial and toxicity: what can proteomics tell us about the nanotoxicology?
Dijendra Nath Roy, Ritobrata Goswami & Ayantika Pal
Pages: 632-643
Published online: 14 Jul 2016
AbstractforNanomaterial and toxicity: what can proteomics tell us about the nanotoxicology? | Full Text | References | PDF (337.4 KB)
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