Xenobiotica, Volume 47, Issue 8 (2017)

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Xenobiotica, Volume 47, Issue 8 (2017)

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General Xenobiochemistry

Article
Effect of nine diets on mRNAs of phase-II conjugation enzymes in livers of mice
Ying Guo, Julia Yue Cui, Hong Lu & Curtis D. Klaassen
Pages: 645-654
Published online: 10 Aug 2016
AbstractforEffect of nine diets on mRNAs of phase-II conjugation enzymes in livers of mice | Full Text | References | PDF (2.6 MB)
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Article
Retrospective use of PBPK modelling to understand a clinical drug–drug interaction between dextromethorphan and GSK1034702
Michael J. Hobbs, Jackie Bloomer & Gordon Dear
Pages: 655-666
Published online: 12 Jan 2017
AbstractforRetrospective use of PBPK modelling to understand a clinical drug–drug interaction between dextromethorphan and GSK1034702 | Full Text | References | PDF (665.5 KB)
  • 357 Views
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Article
Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro
Ying-Yuan Lu, Hai-Xu Cheng, Xin Wang, Xiao-Wei Wang, Jun-Yi Liu, Pu Li, Ya-Qing Lou, Jun Li, Chuang Lu & Guo-Liang Zhang
Pages: 667-672
Published online: 12 Jan 2017
AbstractforIdentification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro | Full Text | References | PDF (573.3 KB) | Supplemental
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Article
An exposure–response analysis based on rifampin suggests CYP3A4 induction is driven by AUC: an in vitro investigation
Cheng Chang, Xin Yang, Odette A. Fahmi, Keith A. Riccardi, Li Di & R. Scott Obach
Pages: 673-681
Published online: 05 Sep 2016
AbstractforAn exposure–response analysis based on rifampin suggests CYP3A4 induction is driven by AUC: an in vitro investigation | Full Text | References | PDF (1 MB) | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline
Jimmy Flarakos, Yancy Du, Helen Gu, Lai Wang, Heidi J. Einolf, Dung Y. Chun, Bing Zhu, Natalia Alexander, Adrienne Natrillo, Imad Hanna, Lillian Ting, Wei Zhou, Kiran Dole, Haiying Sun, Steven J. Kovacs, Daniel S. Stein, S. Ken Tanaka, Stephen Villano & James B. Mangold
Pages: 682-696
Published online: 08 Aug 2016
AbstractforClinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline | Full Text | References | PDF (1.1 MB) | Supplemental
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Open Access
Article
Population pharmacokinetics of mycophenolic acid and its glucuronide metabolite in lung transplant recipients with and without cystic fibrosis
Xiao-Xing Wang, Wenfang Liu, Tian Zheng, Jeong M. Park, David E. Smith & Meihua R. Feng
Pages: 697-704
Published online: 10 Aug 2016
AbstractforPopulation pharmacokinetics of mycophenolic acid and its glucuronide metabolite in lung transplant recipients with and without cystic fibrosis | Full Text | References | PDF (920.2 KB)
  • 307 Views
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Article
Pharmacokinetics and metabolism of [14C]-tozadenant (SYN-115), a novel A2a receptor antagonist ligand, in healthy volunteers
Valérie Mancel, François-Xavier Mathy, Pierre Boulanger, Stephen English, Marie Croft, Christopher Kenney, Tarra Knott, Armel Stockis & Massimo Bani
Pages: 705-718
Published online: 02 Sep 2016
AbstractforPharmacokinetics and metabolism of [14C]-tozadenant (SYN-115), a novel A2a receptor antagonist ligand, in healthy volunteers | Full Text | References | PDF (1.7 MB)
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Xenobiotic Transporters

Article
Intestinal transport of HDND-7, a novel hesperetin derivative, in in vitro MDCK cell and in situ single-pass intestinal perfusion models
Ruonan Chen, Lan Li, Chenlin Shen, Cheng Huang, Taotao Ma, Xiaoming Meng, Zhengyue Qian, Yangyang Li & Jun Li
Pages: 719-730
Published online: 15 Sep 2016
AbstractforIntestinal transport of HDND-7, a novel hesperetin derivative, in in vitro MDCK cell and in situ single-pass intestinal perfusion models | Full Text | References | PDF (963 KB)
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Topics in Xenobiochemistry

Review
Fate of thianthrene in biological systems
Steve C. Mitchell & Rosemary H. Waring
Pages: 731-740
Published online: 25 Aug 2016
AbstractforFate of thianthrene in biological systems | Full Text | References | PDF (479.8 KB)
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